Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Advanced Science, Journal Year: 2023, Volume and Issue: 10(22)

Published: May 31, 2023

Abstract Cancer immunotherapies have improved human health, and one among the important technologies for cancer immunotherapy is vaccine. Antigens are most components in vaccines. Generally, antigens vaccines can be divided into two categories: pre‐defined unidentified antigens. Although, loaded with predefined commonly used, vaccine mixed antigens, especially whole cells or cell lysates, a very promising approach, such obviate some limitations Their advantages include, but not limited to, inclusion of pan‐spectra (all kinds of) inducing pan‐clones specific T cells, overcoming heterogeneity cells. In this review, recent advances based on whole‐tumor either summarized. terms focus applying water‐soluble lysates as Recently, utilizing has become feasible. Considering that pre‐determined antigen‐based (mainly peptide‐based mRNA‐based) various limitations, developing alternative.

Language: Английский

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Tumor Microenvironment‐Responsive Nanoparticles Amplifying STING Signaling Pathway for Cancer Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)

Published: Sept. 19, 2023

Abstract Insufficient activation of the stimulator interferon genes (STING) signaling pathway and profoundly immunosuppressive microenvironment largely limits effect cancer immunotherapy. Herein, tumor (TME)‐responsive nanoparticles (PMM NPs) are exploited that simultaneously harness STING Toll‐like receptor 4 (TLR4) to augment via TLR4‐mediated nuclear factor‐kappa B stimulation, leading increased secretion type I interferons (i.e., 4.0‐fold enhancement IFN‐β) pro‐inflammatory cytokines promote a specific T cell immune response. Moreover, PMM NPs relieve immunosuppression TME by decreasing percentage regulatory cells, polarizing M2 macrophages M1 type, thus creating an immune‐supportive unleash cascade adaptive Combined with anti‐PD‐1 antibody, synergistic efficacy is achieved in both inflamed colorectal noninflamed metastatic breast models. rechallenging tumor‐free animals homotypic cells induced complete rejection, indicating generation systemic antitumor memory. These TME‐responsive may open new avenue achieve spatiotemporal orchestration activation, providing promising clinical candidate for next‐generation

Language: Английский

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Biomedical Metal–Organic Framework Materials: Perspectives and Challenges

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(43)

Published: Nov. 21, 2023

Abstract Metal–organic framework (MOF) materials are gaining significant interest in biomedical research, owing to their high porosity, crystallinity, and structural compositional diversity. Their versatile hybrid organic/inorganic chemistry endows MOFs with the capacity retain organic (drug) molecules, metals, gases, effectively channel electrons photons, survive harsh physiological conditions such as low pH, even protect sensitive biomolecules. Extensive preclinical research has been carried out treat several pathologies and, recently, integration other stents implants demonstrated promising performance regenerative medicine. However, there remains a gap between MOF translation into clinically societally relevant medicinal products. Here, intrinsic features of outlined suitability specific applications detoxification, drug gas delivery, or (combination) therapy platforms is discussed. Furthermore, examples how have engineered evaluated different medical indications, including cancer, microbial, inflammatory diseases described. Finally, challenges facing clinic critically examined, goal establishing directions more realistic approaches that can bridge translational MOF‐containing (nano)materials.

Language: Английский

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Mn-based cGAS-STING activation for tumor therapy

Chinese Journal of Cancer Research, Journal Year: 2023, Volume and Issue: 35(1), P. 19 - 43

Published: Jan. 1, 2023

Immunotherapy has efficiently revolutionized the treatment of human neoplastic diseases. However, overall responsive rate current immunotherapy is still unsatisfactory, benefiting only a small proportion patients. Therefore, significant attention been paid to modulation tumor microenvironment (TME) for enhancement immunotherapy. Interestingly, recent studies have shown that cyclic GMP-AMP synthase-stimulator interferon gene (cGAS-STING) was initially found as an innate immune sensor recognize cytoplasmic DNA (such bacterial, viral, micronuclei, and mitochondrial). It promising signaling pathway activate antitumor responses via type I production. Notably, Mn2+ be critical molecule sensitize activation cGAS-STING better This led development Mn2+-based strategies pathway. In this review, we aimed summarize progress field, focusing on following three aspects. First, briefly introduced activation, its regulation effect immunity cycle discussed. Along with this, several agonists were their potential immunotherapeutic drugs. Then, basic biological functions illustrated, roles in activation. Next, systematically reviewed immunotherapy, which can classified by methods based alone or combined other therapeutic modalities. We finally speculated future perspectives field provided rational suggestions develop therapeutics.

Language: Английский

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Decomposable Nanoagonists Enable NIR‐Elicited cGAS‐STING Activation for Tandem‐Amplified Photodynamic‐Metalloimmunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 14, 2024

Activation of the cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway has emerged as an efficient strategy to improve therapeutic outcomes immunotherapy. However, "constantly active" mode current STING agonist delivery strategies typically leads off-target toxicity and hyperimmunity. To address this critical issue, herein a metal-organic frameworks-based nanoagonist (DZ@A7) featuring tumor-specific near-infrared (NIR) light-enhanced decomposition is constructed for precisely localized activation photodynamic-metalloimmunotherapy. The engineered enabled generation mitochondria-targeted reactive oxygen species under NIR irradiation specifically release mitochondrial DNA (mtDNA) inhibit repair nuclear via hypoxia-responsive drugs. Oxidized tumor mtDNA serves endogenous danger-associated molecular pattern that activates cGAS-STING pathway. Concurrently, NIR-accelerated zinc ions overloading in cancer cells further enhance cGAS enzymatic activity through metalloimmune effects. By combining synergistically enhanced triggered by irradiation, facilitated maturation dendritic infiltration cytotoxic T lymphocytes primary eradication, which also established long-term anti-tumor immunity suppress metastasis. Therefore, developed NIR-triggered, agonist-free, tandem-amplified pathway, thereby offering distinct paradigm

Language: Английский

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Metal‐based smart nanosystems in cancer immunotherapy

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 22, 2024

Abstract Metals are an emerging topic in cancer immunotherapy that have shown great potential modulating immunity cycle and promoting antitumor by activating the intrinsic immunostimulatory mechanisms which been identified recent years. The main challenge of metal‐assisted lies fact free metals as ion forms easily cleared during circulation, even cause systemic metal toxicity due to off‐target effects. With rapid development nanomedicine, metal‐based smart nanosystems (MSNs) with unique controllable structure become one most promising delivery carriers solve issue, owing their various endogenous/external stimuli‐responsiveness release ions for metalloimmunotherapy. In this review, state‐of‐the‐art research progress metal‐related is comprehensively summarized. First, mainstream MSNs‐assisted will be delineated. immunological effects certain categorization MSNs different characters compositions then provided, followed representative exemplar applications treatment, synergistic combination immunotherapy. Finally, we conclude review a summary remaining challenges associated provide authors' perspective on further advances.

Language: Английский

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Cancer Nanovaccines: Nanomaterials and Clinical Perspectives

Small, Journal Year: 2024, Volume and Issue: 20(35)

Published: May 1, 2024

Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.

Language: Английский

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Manganese Dioxide-Entrapping Dendrimers Co-Deliver Protein and Nucleotide for Magnetic Resonance Imaging-Guided Chemodynamic/Starvation/Immune Therapy of Tumors

ACS Nano, Journal Year: 2023, Volume and Issue: 17(23), P. 23889 - 23902

Published: Nov. 25, 2023

Development of a nanoscale drug delivery system that can simultaneously exert efficient tumor therapeutic efficacy while creating the desired antitumor immune responses is still challenging. Herein, we report use manganese dioxide (MnO2)-entrapping dendrimer nanocarrier to codeliver glucose oxidase (GOx) and cyclic GMP-AMP (cGAMP), an agonist stimulator interferon genes (STING) for improved chemodynamic/starvation/immune therapy. Methoxy poly(ethylene glycol) (mPEG)- phenylboronic acid (PBA)-modified generation 5 (G5) poly(amidoamine) dendrimers were first synthesized then entrapped with MnO2 nanoparticles (NPs) generate hybrid MnO2@G5-mPEG–PBA (MGPP) NPs. The created MGPP NPs core size 2.8 nm display glutathione depletion ability, favorable Mn2+ release profile under microenvironment mimetic condition enable Fenton-like reaction T1-weighted magnetic resonance (MR) imaging. We show MGPP-mediated GOx facilitates enhanced chemodynamic/starvation therapy cancer cells in vitro, further codelivery cGAMP effectively trigger immunogenic cell death (ICD) strongly promote maturation dendritic cells. In bilateral mouse colorectal model, nanosystem elicits potent performance strong abscopal effect, greatly improving overall survival rate. Importantly, dendrimer-mediated not only allows coordination respective chemodynamic/starvation-triggered ICD augmented STING activation boost systemic responses, but also enables MR imaging, potentially serving as promising nanoplatform responses.

Language: Английский

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cGAS-STING signaling in the tumor microenvironment

Cancer Letters, Journal Year: 2023, Volume and Issue: 577, P. 216409 - 216409

Published: Sept. 23, 2023

Language: Английский

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