Biomaterial-based strategies: a new era in spinal cord injury treatment DOI Creative Commons
Shihong Zhu,

Sheng-Peng Diao,

Xiao‐Yin Liu

et al.

Neural Regeneration Research, Journal Year: 2025, Volume and Issue: 20(12), P. 3476 - 3500

Published: Jan. 13, 2025

Enhancing neurological recovery and improving the prognosis of spinal cord injury have gained research attention recently. Spinal is associated with a complex molecular cellular microenvironment. This complexity has prompted researchers to elucidate underlying pathophysiological mechanisms changes identify effective treatment strategies. Traditional approaches for repair include surgery, oral or intravenous medications, administration neurotrophic factors; however, efficacy these remains inconclusive, serious adverse reactions continue be concern. With advancements in tissue engineering regenerative medicine, emerging strategies now involve nanoparticle-based nanodelivery systems, scaffolds, functional techniques that incorporate biomaterials, bioengineering, stem cell, growth factors as well three-dimensional bioprinting. Ideal biomaterial scaffolds should not only provide structural support neuron migration, adhesion, proliferation, differentiation but also mimic mechanical properties natural tissue. Additionally, facilitate axon neurogenesis by offering adjustable topography range physical biochemical cues. The three-dimensionally interconnected porous structure appropriate physicochemical enabled biomimetic printing technology can maximize potential biomaterials used treating injury. Therefore, correct selection application coupled successful clinical translation, represent promising objectives enhance review elucidates key occurrence regeneration post-injury, including neuroinflammation, oxidative stress, regeneration, angiogenesis. briefly discusses critical role systems injured cord, highlighting influence nanoparticles affect delivery efficiency. Finally, this highlights It various types their integrations cells factors, optimization scaffold design.

Language: Английский

Supramolecular hydrogels for wound repair and hemostasis DOI

Shaowen Zhuo,

Yongping Liang,

Zhengying Wu

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(1), P. 37 - 101

Published: Oct. 27, 2023

The unique network characteristics and stimuli responsiveness of supramolecular hydrogels have rendered them highly advantageous in the field wound dressings, showcasing unprecedented potential. However, there are few reports on a comprehensive review hydrogel dressings for repair hemostasis. This first introduces major cross-linking methods hydrogels, which includes hydrogen bonding, electrostatic interactions, hydrophobic host-guest metal ligand coordination some other interactions. Then, we advanced materials reported recent years then summarize basic principles each method. Next, classify structures before outlining their forming process propose potential future directions. Furthermore, also discuss raw materials, structural design principles, material used to achieve functions such as antibacterial function, tissue adhesion, substance delivery, anti-inflammatory antioxidant functions, cell behavior regulation, angiogenesis promotion, hemostasis innovative years. Finally, existing problems well development directions strategy, design, discussed. is proposed stimulate further exploration by researchers future.

Language: Английский

Citations

52
Robust and Multifunctional Nanoparticles Assembled from Natural Polyphenols and Metformin for Efficient Spinal Cord Regeneration DOI
Taoyang Yuan, Tianyou Wang, Jianhua Zhang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(18), P. 18562 - 18575

Published: Sept. 14, 2023

The treatment of spinal cord injury (SCI) remains unsatisfactory owing to the complex pathophysiological microenvironments at site and limited regenerative potential central nervous system. Metformin has been proven in clinical animal experiments repair damaged structures functions by promoting endogenous neurogenesis. However, early stage acute SCI, adverse microenvironment sites, such as reactive oxygen species inflammatory factor storm, can prevent activation neural stem cells (NSCs) differentiation NSCs into neurons, decreasing whole effect. To address those issues, a series robust multifunctional natural polyphenol-metformin nanoparticles (polyphenol-Met NPs) were fabricated with pH-responsiveness excellent antioxidative capacities. resulting NPs possessed several favorable advantages: First, composed active ingredients different biological properties, without need for carriers; second, feature could allow targeted drug delivery injured site; more importantly, enabled drugs performances exhibit strong synergistic effects. results demonstrated that improved polyphenols boosted activated neurons oligodendrocytes, which efficiently nerve enhance functional recovery SCI rats. This work highlighted design fabrication via efficient microenvironmental regulation activation.

Language: Английский

Citations

43
Injectable hydrogels as promising in situ therapeutic platform for cartilage tissue engineering DOI
Rong Cai,

Yisi Shan,

F. Du

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129537 - 129537

Published: Jan. 25, 2024

Language: Английский

Citations

21
A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral Nerve Repair DOI Creative Commons
Bing Xia, Xue Gao,

Jiaqi Qian

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Sept. 1, 2023

Abstract Extracellular vesicles (EVs) have inherent advantages over cell‐based therapies in regenerative medicine because of their cargos abundant bioactive cues. Several strategies are proposed to tune EVs production vitro. However, it remains a challenge for manipulation vivo, which poses significant difficulties EVs‐based that aim promote tissue regeneration, particularly long‐term treatment diseases like peripheral neuropathy. Herein, superparamagnetic nanocomposite scaffold capable controlling on‐demand is constructed by incorporating polyethyleneglycol/polyethyleneimine modified nanoparticles into polyacrylamide/hyaluronic acid double‐network hydrogel (Mag‐gel). The Mag‐gel highly sensitive rotating magnetic field (RMF), and can act as mechano‐stimulative platform exert micro/nanoscale forces on encapsulated Schwann cells (SCs), an essential glial cell supporting nerve regeneration. By switching the ON/OFF state RMF, scale up local SCs‐derived (SCs‐EVs) both vitro vivo. Further transcriptome sequencing indicates enrichment transcripts favorable axon growth, angiogenesis, inflammatory regulation SCs‐EVs with ultimately results optimized repair Overall, this research provides noninvasive remotely time‐scheduled method fine‐tuning accelerate including nerves.

Language: Английский

Citations

36
Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications DOI Creative Commons
Zhen‐Gang Sun,

Danzhu Zhu,

Hong Zhao

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 24, 2023

Abstract Functional hydrogels show potential application in repairing spinal cord injury (SCI) due to their unique chemical, physical, and biological properties functions. In this comprehensive review, we present recent advance the material design, functional regulation, SCI repair applications of bioactive hydrogels. Different from previously released reviews on three-dimensional scaffolds for repair, work focuses strategies design biologically regulation hydrogels, specifically aiming how these significant efforts can promoting performance SCI. We demonstrate various methods techniques fabrication with components such as DNA, proteins, peptides, biomass polysaccharides, biopolymers obtain including cell biocompatibility, self-healing, anti-bacterial activity, injectability, bio-adhesion, bio-degradation, other multi-functions The drugs/growth factors, polymers, nanoparticles, one-dimensional materials, two-dimensional materials highly effective treating are introduced discussed detail. This shows new viewpoints ideas synthesis state-of-the-art knowledges science nanotechnology, will bridge connection biomedicine, further inspire clinical biomedical fields.

Language: Английский

Citations

31
Hydrogel scaffolds in the treatment of spinal cord injury: a review DOI Creative Commons

Manqi Cai,

Liji Chen, Tao Wang

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: May 31, 2023

Spinal cord injury (SCI) is a disease of the central nervous system often caused by accidents, and its prognosis unsatisfactory, with long-term adverse effects on patients’ lives. The key to treatment lies in improvement microenvironment at reconstruction axons, tissue repair promising therapeutic strategy. Hydrogel three-dimensional mesh structure high water content, which has advantages biocompatibility, degradability, adjustability, can be used fill pathological defects injectable flowing hydrophilic material situ accurately adapt size shape injury. Hydrogels mimic natural extracellular matrix for cell colonization, guide axon extension, act as biological scaffold, an excellent carrier participate SCI. addition different materials make composite hydrogel scaffolds further enhance their performance all aspects. In this paper, we introduce several typical hydrogels review research progress SCI provide reference clinical application therapy

Language: Английский

Citations

23
Mesenchymal Stem Cell Spheroids Induced by Supramolecular Nanofibers for Diabetic Wound Healing DOI
Yanwen Zhang, Sifan Ai,

Zeming Yu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)

Published: Feb. 14, 2024

Abstract Diabetic wounds, which are a serious complication of diabetes, threat to most diabetic patients and there is lack satisfactory therapeutic strategies. Mesenchymal stem cell (MSC) spheroids under intensive investigation have emerged as particularly promising clinical therapy induce wound healing; however, applications MSC lagged because the difficulties related proper preparation, in situ instruction insufficient efficacy. Herein, novel Biotin‐ D FYIGSR supramolecular hydrogel designed for three‐dimensional (3D) culture MSCs, enables monodispersed MSCs form with high efficacy fairly suitable quick spheroid harvest. demonstrated enhanced paracrine function, exhibited increased survival promoted three overlapping stages healing through integrin α 2 β 1 subunits. These not only accelerated transition from inflammatory phase proliferation by inhibiting neutrophils inducing M2 macrophage transition, but also neovascularization at sites motivate skin regeneration. Ultimately, achieved re‐epithelialization collagen deposition desirable closure. induced facile solution safe efficient treatment great potential application.

Language: Английский

Citations

13
Enhancing calvarial defects repair with PDGF-BB mimetic peptide hydrogels DOI
Xia Wu, Mingming Yan,

Jun Shen

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 277 - 286

Published: May 1, 2024

Language: Английский

Citations

12
Essential elements for spatiotemporal delivery of growth factors within bio-scaffolds: A comprehensive strategy for enhanced tissue regeneration DOI
Tan Chen, Yao Jiang, Jia‐Ping Huang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 97 - 114

Published: Feb. 21, 2024

Language: Английский

Citations

11
Bio‐Functional Hydrogel Microspheres for Musculoskeletal Regeneration DOI
Jielai Yang, Pengfei Xia,

Fanshu Meng

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: Feb. 29, 2024

Abstract The worldwide prevalence of musculoskeletal disorders is expected to rise due an accelerating aging population and increasing associated factors. Despite the high rate disability induction, clinical options for treatment remain limited. Hydrogel microspheres (HMSs), which are colloidal particles with crosslinked polymer networks at nanometer scale, characterized by excellent biocompatibility, easy‐to‐tune structures (e.g., stiffness, porosity, composition), encapsulation efficiency therapeutic agents drugs cells). At present, multiple techniques utilized fabrication HMSs agents. can be produced used in different states match specific utilizations. These desirable properties, along their injectability, bestow mutifunctionalities that a variety biomedical applications delivery biologics, tissue regeneration, bio‐lubrication), thus enable them promising tools tackling diseases. Herein, focus application i) bone disorders, ii) cartilage osteochondral iii) intervertebral disc (IVD) iv) neurovascular aim overviewing recent progress summarize key contributions findings highlight limitations opportunities this field.

Language: Английский

Citations

9