Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Language: Английский

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Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215560 - 215560

Published: Nov. 27, 2023

Language: Английский

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Engineered macrophage-derived cellular vesicles for NIR-II fluorescence imaging-guided precise cancer photo-immunotherapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 235, P. 113770 - 113770

Published: Feb. 1, 2024

Language: Английский

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Leveraging Semiconducting Polymer Nanoparticles for Combination Cancer Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(1)

Published: Oct. 21, 2023

Abstract Cancer immunotherapy has become a promising method for cancer treatment, bringing hope to advanced patients. However, immune‐related adverse events caused by also bring heavy burden Semiconducting polymer nanoparticles (SPNs) as an emerging nanomaterial with high biocompatibility, can eliminate tumors and induce tumor immunogenic cell death through different therapeutic modalities, including photothermal therapy, photodynamic sonodynamic therapy. In addition, SPNs work functional nanocarrier synergize variety of immunomodulators amplify anti‐tumor immune responses. this review, SPNs‐based combination is comprehensively summarized according the SPNs’ modalities type loaded immunomodulators. The in‐depth understanding existing will hopefully inspire design more novel nanomaterials potent effects, ultimately promote their clinical translation.

Language: Английский

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Phase and Defect Engineering of MoSe₂ Nanosheets for Enhanced NIR-II Photothermal Immunotherapy

Nano Letters, Journal Year: 2024, Volume and Issue: 24(25), P. 7764 - 7773

Published: June 12, 2024

Inducing immunogenic cell death (ICD) during photothermal therapy (PTT) has the potential to effectively trigger immunotherapy (PTI). However, ICD induced by PTT alone is often limited inefficient PTT, low immunogenicity of tumor cells, and a dysregulated redox microenvironment. Herein, we develop MoSe2 nanosheets with high-percentage metallic 1T phase rich exposed active Mo centers through defect engineering as an effective nanoagent for PTI. The in endows them strong performance, abundant endow high activity glutathione (GSH) depletion. MoSe2-mediated high-performance synergizing efficient GSH depletion facilitates release tumor-associated antigens induce robust ICD, thus significantly enhancing checkpoint blockade activating systemic immune response mouse models colorectal cancer triple-negative metastatic breast cancer.

Language: Английский

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A NIR‐II‐Emissive Organic Nanomedicine with Biomimetic Engineering for High‐Contrast Targeted Bioimaging and Multiple Phototherapies of Pancreatic Tumors

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract Recent advances are achieved in the design and development of efficient organic photosensitizers (PSs), especially with fluorescence imaging navigation second near‐infrared (NIR‐II, 1000–1700 nm) region. However, there simply a handful NIR‐II emissive PSs oxygen‐independent capability due to scarcity high‐performance NIR‐responsive materials targeted delivery. Herein, NIR‐II‐emissive nanomedicine biomimetic engineering for multiple phototherapies pancreatic tumors is reported. An A‐D‐A‐type conjugated small‐molecule TPC designed used prepare water‐dispersive nanoparticles, which demonstrated high efficiency type I II photodynamic performances, good photothermal conversion 57%, bright emission quantum yield 9.8% under 808 nm light irradiation. With cancer cell membrane camouflage, high‐resolution bioimaging whole‐body blood vessels tumors. Antitumor experiments tumor elimination biosafety This work versatile enhanced tumor‐targeting superior phototheranostics, providing feasible idea evolution theranostics.

Language: Английский

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Precision USPIO-PEG-SLex Nanotheranostic Agent Targeted Photothermal Therapy for Enhanced Anti-PD-L1 Immunotherapy to Treat Immunotherapy Resistance

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1249 - 1272

Published: Feb. 1, 2024

Background: The anti-Programmed Death-Ligand 1 (termed aPD-L1) immune checkpoint blockade therapy has emerged as a promising treatment approach for various advanced solid tumors. However, the effect of aPD-L1 inhibitors limited by tumor microenvironment makes most patients exhibit immunotherapy resistance. Methods: We conjugated Sialyl Lewis X with polyethylene glycol-coated ultrasmall superparamagnetic iron oxide (USPIO-PEG) to form UPS nanoparticles (USPIO-PEG-SLe x , termed UPS). physicochemical properties were tested and characterized. Transmission electron microscopy ICP-OES used observe cellular uptake targeting ability UPS. Flow cytometry, mitochondrial membrane potential staining, live-dead staining scratch assay verify in vitro photothermal UPS, stimulation on immune-related pathways at gene level was analyzed sequencing. Biological safety analysis pharmacokinetic performed. Finally, amplification UPS-mediated aPD-L1-mediated corresponding mechanism studied. Results: In experiments showed that had strong able stimulate 5 pathways. vivo, when PTT assisted treatment, it exhibited significant increase CD4 + T cell infiltration 14.46-fold CD8 14.79-fold, along elevated secretion necrosis factor-alpha interferon-gamma, comparing alone aPD-L1. This achieved inhibition both primary tumors distant compared aPD-L1, demonstrating difference. Conclusion: nanotheranostic agent been introduced into immunotherapy, which effectively broadened its application biomedicine. therapeutic enhancing efficacy therapy, can be instructive address challenges associated resistance, thereby offering clinical translation. Keywords: blockade, agent,

Language: Английский

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Nanoparticle-mediated immunogenic cell death for cancer immunotherapy

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 656, P. 124045 - 124045

Published: March 30, 2024

Language: Английский

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Supramolecular prodrug-like nanotheranostics with dynamic and activatable nature for synergistic photothermal immunotherapy of metastatic cancer

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 354 - 365

Published: Feb. 1, 2024

Language: Английский

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Nanocodelivery of an NIR photothermal agent and an acid-responsive TLR7 agonist prodrug to enhance cancer photothermal immunotherapy and the abscopal effect

Biomaterials, Journal Year: 2023, Volume and Issue: 305, P. 122434 - 122434

Published: Dec. 17, 2023

Language: Английский

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