Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 6, 2025
Reactive
oxygen
species
(ROS)
is
promising
in
cancer
therapy
by
accelerating
tumor
cell
death,
whose
therapeutic
efficacy,
however,
greatly
limited
the
hypoxia
microenvironment
(TME)
and
antioxidant
defense.
Amplification
of
oxidative
stress
has
been
successfully
employed
for
therapy,
but
interactions
between
cells
other
factors
TME
usually
lead
to
inadequate
treatments.
To
tackle
this
issue,
we
develop
a
pH/redox
dual-responsive
nanomedicine
based
on
remodeling
cancer-associated
fibroblasts
(CAFs)
multi-pronged
amplification
ROS
(ZnPP@FQOS).
It
demonstrated
that
generated
ZnPP@FQOS
endogenously/exogenously
multiply
amplified
owing
CAFs
down-regulation
anti-oxidative
cells,
ultimately
achieving
efficient
photodynamic
female
tumor-bearing
mouse
model.
More
importantly,
verified
enable
stimulation
enhanced
immune
responses
systemic
immunity.
This
strategy
remarkably
potentiates
efficacy
photodynamic-immunotherapy,
thus
providing
enlightenment
therapy.
The
reactive
Here,
authors
address
these
limitations
developing
microenvironment-responsive
hybrid
associated
ROS.
Redox Biology,
Journal Year:
2023,
Volume and Issue:
68, P. 102952 - 102952
Published: Nov. 4, 2023
Tamoxifen
(TAM)
resistance
remains
a
major
obstacle
in
the
treatment
of
advanced
breast
cancer
(BCa).
In
addition
to
competitive
inhibition
estrogen
receptor
(ER)
signaling
pathway,
damping
mitochondrial
function
by
increasing
reactive
oxygen
species
(ROS)
is
critical
for
enhancing
TAM
pharmacodynamics.
Here,
we
showed
that
RelB
contributes
inhibiting
TAM-provoked
ferroptosis.
TAM-induced
ROS
level
promoted
ferroptosis
TAM-sensitive
cells,
but
effect
was
alleviated
TAM-resistant
cells
with
high
constitutive
levels
RelB.
Mechanistically,
inhibited
transcriptional
upregulating
glutathione
peroxidase
4
(GPX4).
Consequently,
elevating
and
GPX4
sensitive
increased
resistance,
conversely,
depriving
resistant
decreased
resistance.
Furthermore,
suppression
activation
resensitized
vitro
vivo.
The
inactivation
consistently
ferroptosis-mediated
cell
death.
Together,
this
study
uncovered
BCa
via
RelB-upregulated
GPX4.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(6), P. 2071 - 2080
Published: Feb. 2, 2024
Ferroptosis
is
a
novel
type
of
nonapoptotic
programmed
cell
death
involving
the
accumulation
lipid
peroxidation
(LPO)
to
lethal
threshold.
Herein,
we
propose
tunable
zeolitic
imidazolate
framework
(ZIFs)-engineered
biodegradable
nanozymes
for
ferroptosis
mediated
by
both
reactive
oxygen
species
(ROS)
and
nitrogen
(RNS).
l-Arginine
utilized
as
an
exogenous
nitric
oxide
donor
loaded
into
hollow
ZIFs@MnO2
artificial
nanozymes,
which
are
formed
etching
ZIFs
with
potassium
permanganate
simultaneously
generating
MnO2
shell
in
situ.
The
constructed
multienzyme-like
activities
including
peroxidase,
oxidase,
catalase
can
release
satisfactory
ROS
RNS
through
cascade
reaction,
consequently
promoting
LPO.
Furthermore,
it
improve
efficiency
three-step
strategy
glutathione
(GSH)
depletion;
that
is,
outer
layer
consumes
GSH
under
slightly
acidic
conditions
downregulates
SLC7A11
reductase,
thus
directly
inhibiting
biosynthesis
indirectly
preventing
regeneration.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 19, 2024
Chemodynamic
therapy
(CDT)
can
induce
cancer
cell
death
through
hydroxyl
radicals
(·OH)
generated
from
Fenton
or
Fenton-like
reactions.
Compared
with
traditional
therapies,
CDT
effectively
overcomes
inevitable
drug
resistance
and
exhibits
low
side
effects.
However,
clinical
application
still
faces
challenges,
primarily
due
to
insufficient
·OH
generation
the
short-lifetime
of
in
vivo.
To
address
these
we
developed
a
peroxynitrite
(ONOO
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(21), P. 14722 - 14741
Published: Jan. 1, 2024
Manganese-based
nanomaterials
have
seen
rapid
development
in
chemodynamic
therapy
and
T
1
-enhanced
MRI
over
the
past
five
years,
holding
promising
prospects
various
combined
applications.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(22)
Published: May 1, 2024
Abstract
The
immunosuppressive
tumor
microenvironment
(ITME)
of
osteosarcoma
(OS)
poses
a
significant
obstacle
to
the
efficacy
existing
immunotherapies.
Despite
attempt
novel
immune
strategies
such
as
checkpoint
inhibitors
and
vaccines,
their
effectiveness
remains
suboptimal
due
inherent
difficulty
in
mitigating
ITME
simultaneously
from
both
system.
promotion
anti‐tumor
immunity
through
induction
immunogenic
cell
death
activation
cGAS‐STING
pathway
has
emerged
potential
counter
stimulate
systemic
antitumor
responses.
Here,
bimetallic
polyphenol‐based
nanoplatform
(Mn/Fe‐Gallate
nanoparticles
coated
with
membranes
is
presented,
MFG@TCM)
which
combines
mild
photothermal
therapy
(PTT)
for
reversing
via
inducing
pyroptosis
OS
cells
activating
dendritic
(DCs).
immunostimulatory
pathways,
syngeneic
effect,
exerted
substantial
positive
impact
on
promoting
secretion
damage‐associated
molecular
patterns
(DAMPs)
proinflammatory
cytokines,
favors
remodeling
microenvironment.
Consequently,
effector
T
led
notable
response,
effectively
inhibiting
growth
primary
distant
tumors.
This
study
proposes
new
method
treating
using
PTT
mudulation,
showing
promise
overcoming
current
treatment
limitations.
