Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 7(6)
Published: Oct. 23, 2024
Language: Английский
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: Aug. 16, 2024
Cuproptosis is a newly identified form of cell death induced by excessive copper (Cu) accumulation within cells. Mechanistically, cuproptosis results from Cu-induced aggregation dihydrolipoamide S-acetyltransferase, correlated with the mitochondrial tricarboxylic acid cycle and loss iron–sulfur cluster proteins, ultimately resulting in proteotoxic stress triggering death. Recently, has garnered significant interest tumor research due to its potential as crucial therapeutic strategy against cancer. In this review, we summarized cellular molecular mechanisms relationship other types Additionally, reviewed current drugs or strategies available induce cells, including Cu ionophores, small compounds, nanomedicine. Furthermore, targeted metabolism specific regulatory genes cancer therapy enhance sensitivity cuproptosis. Finally, discussed feasibility targeting overcome chemotherapy immunotherapy resistance suggested future directions. This study that could open new avenues for developing therapy.
Language: Английский
Citations
21
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 15, 2025
Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.
Language: Английский
Citations
2
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.
Language: Английский
Citations
2
European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 288, P. 117427 - 117427
Published: Feb. 20, 2025
Language: Английский
Citations
2
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)
Published: April 15, 2024
Abstract Cuproptosis, a recently identified non‐apoptotic programmed cell death modality, attracts considerable attention in the realm of cancer therapeutics owing to its unique cellular demise mechanisms. Since initial report 2022, strategies inducing or amplifying cuproptosis for treatment emerge. The engineering nano‐systems elicit effectively circumvents constraints associated with conventional small‐molecule pharmaceutical interventions, presenting novel prospects oncological therapy. Stimulus‐responsive nanomaterials, leveraging their distinctive spatiotemporal control attributes, are investigated role modulating induction augmentation cuproptosis. In this comprehensive review, physiological characteristics cuproptosis, encompassing facets such as copper overload and depletion, coupled regulatory factors intrinsic expounded upon. Subsequently, design methodologies stimulus‐responsive enhancement employing stimuli light, ultrasound, X‐ray, tumor microenvironment, systematically delineated. This review encompasses intricacies nanomaterial design, insights into therapeutic processes, advantages. Finally, challenges inherent induction/enhancement deliberated upon prospective future trajectory copper‐mediated therapy provided.
Language: Английский
Citations
16
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(44)
Published: Aug. 5, 2024
Implant-associated infections (IAIs) are the main cause of prosthetic implant failure. Bacterial biofilms prevent antibiotic penetration, and unique metabolic conditions in hypoxic biofilm microenvironment may limit efficacy conventional treatment. Escaping survival bacteria not be continually eradicated, resulting recurrence IAIs. Herein, a sonosensitive metal-organic framework Cu-TCPP (tetrakis(4-carboxyphenyl) porphyrin) nanosheets tinidazole doped probiotic-derived membrane vesicles (OMVs) with high-penetration sonodynamic therapy (SDT), bacterial state interference, cuproptosis-like death to eradicate IAIs is proposed. The can convert O
Language: Английский
Citations
16
Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)
Published: June 25, 2024
Abstract Cuproptosis, a newly identified copper (Cu)-dependent form of cell death, stands out due to its distinct mechanism that sets it apart from other known death pathways. The molecular underpinnings cuproptosis involve the binding Cu lipoylated enzymes in tricarboxylic acid cycle. This interaction triggers enzyme aggregation and proteotoxic stress, culminating death. specific has yet be fully elucidated. recognized sparked numerous investigations into role tumorigenesis cancer therapy. In this review, we summarized current knowledge on metabolism link cancer. Furthermore, delineated mechanisms roles cuproptosis-related genes Finally, offered comprehensive discussion most recent advancements ionophores nanoparticle delivery systems utilize as cutting-edge strategy for treatment.
Language: Английский
Citations
11
Materials Horizons, Journal Year: 2024, Volume and Issue: 11(18), P. 4275 - 4310
Published: Jan. 1, 2024
This comprehensive review systematically summarizes the intrinsic mechanism of different metal ion (such as Fe 3+ /Fe 2+ , Cu /Cu + Ca Zn Mn Na /K and Mg )-mediated interference therapies their research progress in cancer treatment.
Language: Английский
Citations
9
Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(3)
Published: Jan. 27, 2025
Photodynamic therapy (PDT) is a noninvasive cancer treatment that works by using light to stimulate the production of excessive cytotoxic reactive oxygen species (ROS), which effectively eliminates tumor cells. However, therapeutic effects PDT are often limited hypoxia, prevents effective cell elimination. The (O2) consumption during can further exacerbate leading post-treatment adverse events. This review aims explore potential cuproptosis, recently discovered copper-dependent form programmed death, enhance anticancer PDT. Cuproptosis highly dependent on mitochondrial respiration, specifically tricarboxylic acid (TCA) cycle, and increase O2 ROS levels or decrease glutathione (GSH) levels, thereby improving outcomes. discusses latest research advancements in field, detailing mechanisms regulate cuproptosis It also explores how nanoparticle (NP)-based strategies be used exploit synergistic between article examines prospects activity guided nanodelivery systems, could overcome challenges associated with hypoxia treatment. combination PDT, facilitated NP-based delivery presents promising approach effectiveness therapy. concludes discussing future directions for this therapy, highlighting need investigation into optimization improve outcomes
Language: Английский
Citations
1
ACS Nano, Journal Year: 2024, Volume and Issue: 18(16), P. 10885 - 10901
Published: April 8, 2024
Hypochlorous acid (HClO), as a powerful oxidizer, is obtained from the oxidation of Cl- ions during electrochemical therapy (EChT) process for cancer therapy. However, extracellular generated HClO inadequate to inhibit effective tumor cell death. Herein, manganese-doped potassium chloride nanocubes (MPC NCs) fabricated and modified with amphipathic polymer PEG (PMPC function massive three-dimensional nanoelectrodes (NEs) were developed enhance generation immunotherapy under an alternating electric field. Under square-wave current (AC) field, was boosted by PMPC NEs due enlarged active surface area, enhanced mass transfer rate, improved electrocatalytic activity. Notably, upregulated intracellular concentration induce robust immunogenic death (ICD) AC Meanwhile, electric-triggered release Mn2+ effectively stimulated dendritic cells (DCs) maturation. In vivo results illustrated that PMPC-mediated EChT inhibited growth triggered promotion immune response regulate microenvironment. Based on potent antitumor immunity, further combined checkpoint inhibitor (αCTLA-4) realize EChT-immunotherapy, which demonstrated inhibition primary tumors abscopal effect distant tumors. To summarize, our work highlights application electrochemical-immunotherapy technology in
Language: Английский
Citations
7