Nano-Micro Letters,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: May 12, 2025
Abstract
Single-atom
nanozymes
(SAzymes)
hold
significant
potential
for
tumor
catalytic
therapy,
but
their
effectiveness
is
often
compromised
by
low
efficiency
within
microenvironment.
This
mainly
influenced
key
factors
including
hydrogen
peroxide
(H
2
O
)
availability,
acidity,
and
temperature.
Simultaneous
optimization
of
these
presents
a
challenge
therapy.
In
this
study,
we
developed
comprehensive
strategy
to
refine
single-atom
kinetics
enhancing
therapy
through
dual-enzyme-driven
cascade
reactions.
Iridium
(Ir)
SAzymes
with
high
activity
natural
enzyme
glucose
oxidase
(GOx)
were
utilized
construct
the
reaction
system.
GOx
was
loaded
Ir
due
its
large
surface
area.
Then,
system
modified
cancer
cell
membranes
improving
biocompatibility
achieving
homologous
targeting
ability.
catalysis
could
produce
abundant
H
lower
local
pH,
thereby
optimizing
reaction-limiting
factors.
Additionally,
upon
laser
irradiation,
raise
temperature,
further
dual-enzyme
maximized
performance
SAzymes,
significantly
Our
findings
present
refining
homologous-targeted
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(50), P. 33792 - 33826
Published: Dec. 3, 2024
Alzheimer's
disease
(AD)
is
a
neurodegenerative
that
causes
memory
loss
and
progressive
permanent
deterioration
of
cognitive
function.
The
most
challenging
issue
in
combating
AD
its
complicated
pathogenesis,
which
includes
the
deposition
amyloid
β
(Aβ)
plaques,
intracellular
hyperphosphorylated
tau
protein,
neurofibrillary
tangles
(NFT),
etc.
Despite
rapid
advancements
mechanistic
research
drug
development
for
AD,
currently
developed
drugs
only
improve
ability
temporarily
relieve
symptoms
but
cannot
prevent
AD.
Moreover,
blood–brain
barrier
(BBB)
creates
huge
to
delivery
brain.
Therefore,
effective
diagnostic
tools
treatments
are
urgently
needed.
In
recent
years,
nanomedicine
has
provided
opportunities
overcome
challenges
limitations
associated
with
traditional
diagnostics
or
treatments.
Various
types
nanoparticles
(NPs)
play
an
essential
role
diagnosis
treatment
acting
as
carriers
targeting
bioavailability
across/bypass
BBB
directly
on
lesions.
This
review
categorizes
different
NPs
summarizes
their
applications
It
also
discusses
clinical
explores
latest
developments
prospects
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(3), P. 1526 - 1536
Published: Feb. 21, 2024
Tumoral
thermal
defense
mechanisms
considerably
attenuate
the
therapeutic
outcomes
of
mild-temperature
photothermal
therapy
(PTT).
Thus,
developing
a
simple,
efficient,
and
universal
strategy
to
sensitize
PTT
is
desirable.
Herein,
we
report
self-delivery
nanomedicines
ACy
NPs
comprising
near-infrared
(NIR)
agent
(Cypate),
mitochondrial
oxidative
phosphorylation
inhibitor
(ATO),
distearoylphosphatidylethanolamine-polyethylene
glycol
2000
(DSPE–PEG2000),
which
have
high
drug-loading
efficiency
that
can
reverse
tumoral
resistance,
thereby
increasing
efficacy.
achieved
targeted
tumor
accumulation
performed
NIR
fluorescence
imaging
capability
in
vivo
guide
for
optimized
outcomes.
The
released
ATO
reduced
intracellular
ATP
levels
downregulate
multiple
heat
shock
proteins
(including
HSP70
HSP90)
before
PTT,
reversed
resistance
cells,
contributing
excellent
results
vitro
vivo.
Therefore,
this
study
provides
biosafe,
advanced,
protein-blocking
PTT.
The
nanoscale
multidrug
codelivery
system
for
synergistic
therapy
is
an
effective
strategy
tumor
treatment.
However,
the
low
drug
delivery
efficiency
and
poor
therapeutic
effects
limit
its
application.
Here,
based
on
coordination
effect
of
Artemisinin
(Art),
quercetin
(Qc),
Fe
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 4, 2024
ABSTRACT
To
meet
the
high
requirements
of
biomedical
applications
in
antimicrobial
agents,
it
is
crucial
to
explore
efficient
nano‐antimicrobial
agents
with
no
resistance
and
good
biocompatibility
for
treating
infected
wounds.
In
this
study,
composite
nano‐antibiotic
TPA‐Py@AuNCs⊂BSA
nanoparticles
(TAB
NPs)
are
prepared
using
hollow
mesoporous
Au
nanocages
(AuNCs)
loaded
a
photosensitizer
(namely
TPA‐Py)
D‐π‐A
structure
showing
aggregation‐induced
emission
properties.
When
TPA‐Py
encapsulated
cavity
AuNCs,
its
fluorescence
suppressed.
presence
photothermal
induction,
can
be
released
from
allowing
restoration
illumination
specific
imaging
Gram‐positive
bacteria.
TAB
NPs
demonstrate
outstanding
activity
against
variety
bacteria,
multimodal
property
does
not
lead
development
bacterial
resistance.
vitro
experiments
show
that
could
eliminate
bacteria
ablate
biofilm.
vivo
synergistic
effect
has
significant
positive
impact
on
treatment
wounds,
including
rapid
antibacterial
action,
promotion
M2
macrophage
polarization,
enhancement
chronic
wound
healing.
This
study
provides
an
effective
strategy
developing
wide‐spectrum
nano‐antibiotics
ablation
biofilms
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
An
uncomplicated
template
method
was
employed
to
produce
sulfur
vacancies
(V
S
)-doped
hollow
Co
9
8
nanocages
(Co
8−
x
)
endow
a
single-component
nanomaterial
with
simultaneous
catalytic
activity
and
NIR-II
photothermal
property.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 1, 2025
The
creation
and
development
of
classical
multifunctional
nanomaterials
are
crucial
for
the
advancement
nanotherapeutic
treatments
tumors.
Currently,
metal–organic
frameworks
(MOFs)
modified
with
polydopamine
(PDA)
at
forefront
nanomedicine
research,
particularly
in
tumor
diagnostics
therapy,
owing
to
their
exceptional
biocompatibility,
expansive
specific
surface
area,
multifaceted
functionalities,
superior
photothermal
properties,
which
led
significant
advancements
anti-tumor
research.
Consequently,
a
range
anti-cancer
strategies
has
been
devised
by
leveraging
capabilities
MOFs,
including
intelligent
drug
delivery
systems,
photodynamic
tailored
microenvironment.
In
order
gain
deeper
insight
into
role
MOFs@PDA
cancer
diagnosis
treatment,
it
is
essential
conduct
comprehensive
review
existing
research
outcomes
promptly
analyze
challenges
associated
biological
applications.
This
will
provide
valuable
perspectives
on
potential
clinical
settings.
Regenerative Biomaterials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
In
this
article,
we
fabricated
nanomedicines
with
mitochondrial
targeting
function
and
autophagy
inhibitor
for
enhancing
cancer
photothermal-chemotherapy.
The
nanoparticles
were
gold
(AuNPs)
as
cores
amphiphilic
dextran
(3-carboxypropyl)
triphenyl
phosphorus
bromide
β-cyclodextrin
(β-CD)
modification
(TPP-DCD)
shells;
the
chemotherapeutic
doxorubicin
(DOX)
chloroquine
(CQ)
encapsulated
in
nanoparticles.
TPP-DCD
was
synthesized
via
immobilization
of
2-aminoethanethiol
modified
β-CD
triphenylphosphonium
on
to
receive
coordination
interaction
AuNPs
mitochondria
targeting.
size,
morphology
properties
Au@DOX/CQ@TPP-DCD
studied.
efficiently
targeted
cellular
produce
reactive
oxygen
species
photothermal
effect
under
NIR
irradiation.
released
DOX
CQ
could
not
only
kill
tumor
cells
directly,
but
also
inhibit
enhance
therapeutic
effects.
Both
vitro
vivo
anticancer
activities
investigated
detail.
imaging
demonstrated
that
exhibited
efficient
targeting,
accumulation
retention
tumor-bearing
mice.
apoptosis
suppression
greatly
accelerated
addition
808
nm
nanomedicine
significant
synergistic
therapy,
75%
tumors
mice
disappeared.
nanoparticle
is
a
promising
therapy
Sublethal
tumor
cells
have
an
urgent
need
for
energy,
making
it
common
them
to
switch
metabolic
phenotypes
between
glycolysis
and
oxidative
phosphorylation
(OXPHOS)
compensatory
energy
supply;
thus,
the
synchronous
interference
of
dual
pathways
limiting
level
is
essential
in
inhibiting
sublethal
growth.
Herein,
a
multifunctional
nanoplatform
Co-MOF-loaded
anethole
trithione
(ADT)
myristyl
alcohol
(MA),
modified
with
GOx
hyaluronic
acid
(HA)
was
developed,
namely,
CAMGH.
It
could
synchronously
interfere
including
OXPHOS
restrict
adenosine
triphosphate
(ATP)
supply,
achieving
inhibition
tumors
after
microwave
(MW)
thermal
therapy.
Under
low-power
MW
irradiation,
CAMGH
induced
certain
damage
while
ensuring
safety
surrounding
normal
tissues.
The
loaded
consumed
glucose
tumors,
undoubtedly
blocking
main
supply
pathway,
glycolytic
pathway.
Then,
H
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 1367 - 1382
Published: Feb. 1, 2025
Abstract:
Breast
cancer
remains
a
significant
therapeutic
challenge,
with
the
immune
microenvironment
playing
crucial
role
in
its
progression
and
treatment
response.
This
review
investigates
potential
of
nanoparticles
to
modulate
breast
therapy.
Initially,
we
discuss
composition
influence
on
cancer,
followed
by
current
strategies
targeting
these
components.
We
then
provide
for
cells
such
as
macrophages,
dendritic
cells,
T-cells.
The
enhancing
checkpoint
blockade
(ICB)
their
application
vaccines
is
also
examined.
Additionally,
explore
synergistic
effects
combining
conventional
therapies.
addresses
challenges
clinical
translation,
focusing
safety,
biocompatibility,
toxicity.
Finally,
outline
future
research
directions
advancements
nanoparticle-based
immunotherapy,
emphasizing
transformative
impact
treatment.
Keywords:
nanoparticle,
