Gathering brings strength: How organic aggregates boost disease phototheranostics

Aggregate, Journal Year: 2021, Volume and Issue: 2(1), P. 95 - 113

Published: Jan. 22, 2021

Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially rationally utilize energy dissipation pathways Jablonski diagram to modulate fluorescence emission, photoacoustic/photothermal production, photodynamic processes. Of particular interest are systems exhibiting huge differences aggregate state as compared with solution or single molecule form, during intramolecular motions play an important role regulating properties. The advances from such aspect biomedical applications including high‐resolution imaging, activatable imaging therapy, adaptive theranostics, image‐guided surgery, immunotherapy, afterglow discussed. A brief summary perspective this field also presented. We hope will be helpful researchers interested bioprobe design theranostic inspire new insights into linkage between science field.

Language: Английский

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Biomedical and bioactive engineered nanomaterials for targeted tumor photothermal therapy: A review

Materials Science and Engineering C, Journal Year: 2019, Volume and Issue: 104, P. 109891 - 109891

Published: June 15, 2019

Language: Английский

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Ultrafast Synthesis of Ultrasmall Poly(Vinylpyrrolidone)‐Protected Bismuth Nanodots as a Multifunctional Theranostic Agent for In Vivo Dual‐Modal CT/Photothermal‐Imaging‐Guided Photothermal Therapy

Advanced Functional Materials, Journal Year: 2017, Volume and Issue: 27(35)

Published: July 21, 2017

To elaborately fabricate real‐time monitoring and therapeutic function into a biocompatible nanoplatform is promising route in the cancer therapy field. However, package of diagnosis treatment single‐“element” nanoparticle remains challenge. Herein, ultrasmall poly(vinylpyrrolidone)‐protected bismuth nanodots (PVP‐Bi nanodots) are successfully synthesized through an ultrafacile strategy (1 min only under ambient conditions). The easy to synthesize both laboratory large scale using low‐cost ingredients. PVP‐Bi with size show good biocompatibility. Due high X‐ray attenuation ability Bi element, have prominent performance on computed tomography (CT) imaging. Moreover, exhibit photothermal conversion efficiency (η = 30%) because strong near‐infrared absorbance, which can serve as nanotheranostic agent for imaging therapy. subsequent PVP‐Bi‐nanodot‐mediated (PTT) result shows highly efficient ablation cells vitro vivo. be almost completely excreted from mice after 7 d. Blood biochemistry histology analysis suggests that negligible toxicity. All positive results reveal produced method platform dual‐modal CT/photothermal‐imaging‐guided PTT.

Language: Английский

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Highly Stable Organic Small Molecular Nanoparticles as an Advanced and Biocompatible Phototheranostic Agent of Tumor in Living Mice

ACS Nano, Journal Year: 2017, Volume and Issue: 11(7), P. 7177 - 7188

Published: July 10, 2017

Near-infrared (NIR)-absorbing organic small molecules hold great promise as the phototheranostic agents for clinical translation by virtue of their intrinsic advantages such well-defined chemical structure, high purity, and good reproducibility. However, most currently available ones face challenges in varying degrees terms photothermal instability, photobleaching/reactive oxygen nitrogen species (RONS) inresistance, which indeed impair practical applications precise diagnosis treatment diseases. Herein, we developed highly stable biocompatible nanoparticles (ONPs) effective application design synthesis an molecule (namely TPA-T-TQ) with intensive absorption NIR window. The TPA-T-TQ ONPs no noticeable vivo toxicity possess better capacities conversion photoacoustic imaging (PAI), well show far higher stabilities including thermal/photothermal stabilities, photobleaching/RONS resistances, when compared clinically popularly used indocyanine green. Thanks to combined merits, can serve efficient probe PAI a high-contrast manner, also significantly causes stoppage tumor growth living mice through PAI-guided therapy. This study thus provides insight into development advanced NIR-absorbing applications.

Language: Английский

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Light: A Magical Tool for Controlled Drug Delivery

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(49)

Published: Sept. 9, 2020

Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application and exquisite temporal spatial control. Great progress has been achieved in the development novel light-driven strategies with both breadth depth. Light-controlled platforms can be generally categorized into three groups: photochemical, photothermal, photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, sulfides oxides, metal-organic frameworks, carbon nanomaterials, upconversion semiconductor stimuli-responsive micelles, polymer- liposome-based nanoparticles have applied light-stimulated delivery. In view increasing interest targeted delivery, we review light-responsive systems focus on recent advances, key limitations, future directions.

Language: Английский

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Tumor Targeting Strategies of Smart Fluorescent Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(40)

Published: Aug. 1, 2019

Advantages such as strong signal strength, resistance to photobleaching, tunable fluorescence emissions, high sensitivity, and biocompatibility are the driving forces for application of fluorescent nanoparticles (FNPs) in cancer diagnosis therapy. In addition, large surface area easy modification FNPs provide a platform design multifunctional (MFNPs) tumor targeting, diagnosis, treatment. order obtain better targeting therapeutic effects, it is necessary understand properties mechanisms FNPs, which foundation play key role (NPs). Widely accepted applied enhanced permeability retention (EPR) effect, active microenvironment (TME) summarized here. Additionally, freshly discovered mechanism introduced, termed cell membrane (CMPT), improves tumor-targeting rate from less than 5% EPR effect more 50%. A new strategy also summarized, promising future clinical NPs/nanomedicines design. The will inspire insights thoughts on speed up precision medicine contribute therapy early diagnosis.

Language: Английский

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Ultrathin Molybdenum Carbide MXene with Fast Biodegradability for Highly Efficient Theory‐Oriented Photonic Tumor Hyperthermia

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 29(22)

Published: April 1, 2019

Abstract The explosion of emerging high‐performance 2D MXenes in theranostic nanomedicine is still at the preliminary stage. Despite tremendous efforts devoted to photonic tumor hyperthermia, current photothermal‐conversion nanoagents suffer from critical issues preventing further clinical translation such as low biodegradability. Here, for first time, construction novel molybdenum carbide (Mo 2 C) hyperthermia reported. structure both bulk Mo Ga C ceramic and MXene fully revealed. Especially, computational simulation, a strategy powerful tool photonic‐performance prediction, employed reveal that featured with intense near‐infrared (NIR) absorption, covering second biological transparency window (NIR I II). After surface engineering polyvinyl alcohol (PVA), C‐PVA nanoflakes exhibit high biocompatibility fast degradability. Importantly, it experimentally corroborated possess intriguing broad absorption band spanning NIR II regions, desirable efficiency (24.5% 43.3% This study not only broadens nanomedical applications by fabricating material members C), but also provides paradigm inorganic multifunctional biomedical nanoplatform biodegradability therapeutic performance.

Language: Английский

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NIR‐II Responsive Inorganic 2D Nanomaterials for Cancer Photothermal Therapy: Recent Advances and Future Challenges

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(32)

Published: June 10, 2021

Abstract Non‐invasive cancer photothermal therapy (PTT) is a promising replacement for traditional treatments. The second near‐infrared region induced PTT (NIR‐II PTT, 1000–1500 nm) with less energy dissipation has been developed deeper‐seated tumor treatment in recent years compared the first light (750–1000 nm). In addition, use of emerging inorganic 2D nanomaterials as agents (PTAs) further enhanced efficiency due to their intrinsic properties. NIR‐II stimulated becoming hot topic both academic and clinical fields. This review summarizes categories, structures, conversion properties time. synergistic strategies responsive combined other approaches including chemotherapy, chemodynamic therapy, photodynamic radiotherapy are summarized. future challenges perspectives on these systems construction discussed.

Language: Английский

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Ultrastable and Biocompatible NIR‐II Quantum Dots for Functional Bioimaging

Advanced Functional Materials, Journal Year: 2017, Volume and Issue: 28(9)

Published: Dec. 18, 2017

Abstract Fluorescence bioimaging in the second near‐infrared spectral region (NIR‐II, 1000–1700 nm) can provide advantages of high spatial resolution and large penetration depth, due to low light scattering. However, NIR‐II fluorophores simultaneously possessing brightness, good stability, biocompatibility are very rare. Hydrophobic emissive PbS@CdS quantum dots (QDs) surface‐functionalized, via a silica amphiphilic polymer (Pluronic F‐127) dual‐layer coating method. The as‐synthesized PbS@CdS@SiO 2 @F‐127 nanoparticles (NPs) aqueously dispersible possess yield ≈5.79%, which is much larger than those most existing fluorophores. Thanks protection, NPs show excellent chemical stability wide range pH values. studied, results that toxicity vivo could be minimal. then utilized for real‐time fluorescence microscopic imaging mouse brain. architecture blood vessels visualized depth reaches 950 µm. Furthermore, gastrointestinal tract achieved, by perfusing into mice at rather dosage. This work illustrates potential ultrastable, biocompatible, bright QDs biomedical clinical applications, require deep tissue imaging.

Language: Английский

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“Dual Lock‐and‐Key”‐Controlled Nanoprobes for Ultrahigh Specific Fluorescence Imaging in the Second Near‐Infrared Window

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(31)

Published: June 19, 2018

Fluorescence imaging in the second near-infrared window (NIR-II) is a new technique that permits visualization of deep anatomical features with unprecedented spatial resolution. Although attractive, effectively suppressing interference signal background still an enormous challenge for obtaining target-specific NIR-II complex and dynamic physiological environment. Herein, dual-pathological-parameter cooperatively activatable fluorescence nanoprobes (HISSNPs) are developed whereby hyaluronic acid chains disulfide bonds act as "double locks" to lock fluorescence-quenched aggregation state dyes performing ultrahigh specific tumors vivo. The can be lit up only when opened by reacting "dual smart keys" (overexpressed hyaluronidase thiols tumor) simultaneously. In vivo shows they reduce nonspecific activitation achieve ultralow fluorescence, which 10.6-fold lower than single-parameter probes (HINPs) liver at 15 h postinjection. Consequently, these lock-and-key"-controlled HISSNPs exhibit fivefold higher tumor-to-normal tissue ratio "single HINPs 24 postinjection, attractively realizing specificity tumor imaging. This thought first attempt implementing participation multiple pathological parameters

Language: Английский

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