Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(21), P. 13454 - 13619

Published: Sept. 28, 2021

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is photochemical-based treatment approach that involves the use of light combined with light-activated chemical, referred as PS. Attractively, PDT one alternatives conventional cancer due its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although concept photosensitizer-based photodynamic has been widely adopted clinical trials bioimaging, until now, our surprise, there no relevant article on rational designs organic PDT. Furthermore, most published articles focused nanomaterials nanotechnology based traditional PSs. Therefore, this aimed at reporting recent strategies develop innovative enhanced therapy, each example described detail instead providing only general overview, typically done previous reviews PDT, provide intuitive, vivid, specific insights readers.

Language: Английский

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Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(7)

Published: Jan. 4, 2021

Chemodynamic therapy (CDT) is an emerging method that kills cancer cells by converting intracellular hydrogen peroxide (H2 O2 ) into highly toxic hydroxyl radicals (• OH). To overcome the current limitations of insufficient endogenous H2 and high concentration glutathione (GSH) in tumor cells, intelligent nanocatalytic theranostics (denoted as PGC-DOX) possesses both self-supply GSH-elimination properties for efficient presented. This nanoplatform constructed a facile one-step biomineralization using poly(ethylene glycol)-modified glucose oxidase (GOx) template to form biodegradable copper-doped calcium phosphate nanoparticles, followed loading doxorubicin (DOX). As enzyme catalyst, GOx can effectively catalyze generate , which not only starves but also supplies subsequent Fenton-like reaction. Meanwhile, redox reaction between released Cu2+ ions GSH will induce depletion reduce Fenton agent Cu+ ions, then trigger • OH -mediated reaction, resulting enhanced CDT efficacy. The integration GOx-mediated starvation therapy, CDT, DOX-induced chemotherapy, endow PGC-DOX with effective growth inhibition minimal side effects vivo.

Language: Английский

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Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief

ACS Nano, Journal Year: 2019, Volume and Issue: 13(4), P. 4267 - 4277

Published: March 22, 2019

The integration of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic (CDT) holds great promise for enhanced anticancer effects. Herein, we report biodegradable cancer cell membrane-coated mesoporous copper/manganese silicate nanospheres (mCMSNs) with homotypic targeting ability to the lines ROS generation through singlet (1O2) production glutathione (GSH)-activated Fenton reaction, showing excellent CDT/PDT synergistic therapeutic We demonstrate that mCMSNs are able relieve tumor hypoxia microenvironment by catalytic decomposition endogenous H2O2 O2 further react produce toxic 1O2 a 635 nm laser irradiation. GSH-triggered biodegradation can simultaneously generate Fenton-like Cu+ Mn2+ ions deplete GSH efficient hydroxyl radical (•OH) production. specific recognition cells were also revealed. Notably, relieving depletion disrupts (TME) cellular antioxidant defense system, achieving exceptional cancer-targeting effects in vitro vivo. growth was significantly inhibited. Moreover, released act as an advanced contrast agent magnetic resonance imaging (MRI). Thus, together photosensitizers, provider MRI along modulating TME allow realize MRI-monitored therapy. It provides paradigm rationally design TME-responsive ROS-involved strategies based on single polymetallic nanomaterial

Language: Английский

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Biomedicine Meets Fenton Chemistry

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(4), P. 1981 - 2019

Published: Jan. 25, 2021

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of guidance from a summary its representative applications cancer therapy would help us understand promote further development This comprehensive review supplies basic information regarding chemistry, including reactions Fenton-like reactions. Subsequently, current progress is discussed, with some corresponding examples presented. Furthermore, strategies for optimizing performance chemodynamic guided by are highlighted. Most importantly, future perspectives on combination biomedicine or wider range catalytic approaches We hope that will attract positive attention materials science, fields tighten their connections.

Language: Английский

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Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 328, P. 251 - 262

Published: Sept. 1, 2020

Language: Английский

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Glucose Oxidase‐Instructed Multimodal Synergistic Cancer Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(21)

Published: March 25, 2019

Abstract Over the past 3 years, glucose oxidase (GOx) has aroused great research interest in context of cancer treatment due to its inherent biocompatibility and biodegradability, unique catalytic properties against β‐ d ‐glucose. GOx can effectively catalyze oxidation into gluconic acid hydrogen peroxide. This process depletes oxygen levels, resulting elevated acidity, hypoxia, oxidative stress tumor microenvironment. All these changes be readily harnessed develop a multimodal synergistic therapy by combining with other therapeutic approaches. Herein, representative studies GOx‐instructed are introduced, their mechanisms discussed systematically. The current challenges future prospects advance development GOx‐based nanomedicines this cutting‐edge area highlighted.

Language: Английский

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An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: April 8, 2020

Abstract The therapeutic effect of reactive oxygen species (ROS)-involved cancer therapies is significantly limited by shortage oxy-substrates, such as hypoxia in photodynamic therapy (PDT) and insufficient hydrogen peroxide (H 2 O ) chemodynamic (CDT). Here, we report a H /O self-supplying nanoagent, (MSNs@CaO -ICG)@LA, which consists manganese silicate (MSN)-supported calcium (CaO indocyanine green (ICG) with further surface modification phase-change material lauric acid (LA). Under laser irradiation, ICG simultaneously generates singlet emits heat to melt the LA. exposed CaO reacts water produce for hypoxia-relieved ICG-mediated PDT -supplying MSN-based CDT, acting an open source strategy ROS production. Additionally, MSNs-induced glutathione depletion protects from scavenging, termed reduce expenditure. This expenditure effective inhibiting tumor growth both vitro vivo, improves generation efficiency multi-level ROS-involved therapies.

Language: Английский

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Small, Journal Year: 2021, Volume and Issue: 18(6)

Published: Nov. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Language: Английский

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Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(10)

Published: Jan. 28, 2020

Abstract Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO 2 , MnO, Mn O 3 4 x ) their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, representative progresses MONs synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, are mainly introduced. First, five kinds primary synthetic methods presented, thermal decomposition method, exfoliation strategy, permanganates reduction adsorption–oxidation hydro/solvothermal. Second, preparations hollow composite materials summarized specially. Then, chemical toxicity discussed. Next, diagnostic imaging sensing outlined. Finally, some rational designs photodynamic therapy, photothermal chemodynamic sonodynamic radiotherapy, magnetic hyperthermia, chemotherapy, gene starvation ferroptosis, immunotherapy, various combination highlighted.

Language: Английский

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Biodegradable Manganese-Doped Calcium Phosphate Nanotheranostics for Traceable Cascade Reaction-Enhanced Anti-Tumor Therapy

ACS Nano, Journal Year: 2019, Volume and Issue: 13(12), P. 13985 - 13994

Published: Dec. 13, 2019

Glucose oxidase (GOx) has been recognized as a "star" enzyme catalyst involved in cancer treatment the past few years. Herein, GOx is mineralized with manganese-doped calcium phosphate (MnCaP) to form spherical nanoparticles (GOx-MnCaP NPs) by an situ biomimetic mineralization method, followed loading of doxorubicin (DOX) construct biodegradable, biocompatible, and tumor acidity-responsive nanotheranostics for magnetic resonance imaging (MRI) cascade reaction-enhanced cooperative treatment. The GOx-driven oxidation reaction can effectively eliminate intratumoral glucose starvation therapy, elevated H2O2 then converted into highly toxic hydroxyl radicals via Mn2+-mediated Fenton-like chemodynamic therapy (CDT). Moreover, acidity amplification due gluconic acid generation will turn accelerate degradation nanoplatform promote Mn2+-H2O2 enhanced CDT. Meanwhile, released Mn2+ ions be used MRI monitor process. After carrying anticancer drug, DOX-loaded GOx-MnCaP integrate CDT, DOX-induced chemotherapy together, which showed greatly improved therapeutic efficacy than each monotherapy. Such orchestrated demonstrated high-efficiency suppression on 4T1 tumor-bearing mice minimal side effects. Our findings suggested that excellent biodegradability biocompatibility hold clinical translation potential management.

Language: Английский

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