A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Nano-Micro Letters, Journal Year: 2021, Volume and Issue: 13(1)

Published: July 9, 2021

Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress nanozymes has been made with deep investigation of diverse and rapid development related nanotechnologies. As promising alternatives for natural enzymes, have broadened way toward clinical medicine, food safety, environmental monitoring, chemical production. The past decade witnessed metal- metal oxide-based owing their remarkable physicochemical properties parallel low cost, high stability, easy storage. It is widely known that study catalytic activities mechanism sheds significant influence on applications nanozymes. This review digs into characteristics intrinsic nanozymes, especially emphasizing recent biological analysis, relieving inflammation, antibacterial, cancer therapy. We also conclude present challenges provide insights future constituted oxide nanomaterials.

Language: Английский

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Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy

Nano Letters, Journal Year: 2019, Volume and Issue: 19(6), P. 4134 - 4145

Published: May 14, 2019

As a noninvasive treatment modality, ultrasound (US)-triggered sonodynamic therapy (SDT) shows broad and promising applications to overcome the drawbacks of traditional photodynamic (PDT) in combating cancer. However, SDT efficacy is still not satisfactory without oxygen (O2) assistance. In addition, there also much space explore SDT-based synergistic therapeutic modalities. Herein, novel Pt-CuS Janus composed hollow semiconductor CuS noble metallic Pt was rationally designed successfully synthesized. The large inner cavity for loading sonosensitizer molecules (tetra-(4-aminophenyl) porphyrin, TAPP) implement SDT. Moreover, deposition only enhances photothermal performance compared with those nanoparticles (NPs) due effect local electric field enhancement but possesses nanozyme activity catalyzing decomposition endogenous overexpressed hydrogen peroxide (H2O2) produce O2 that can tumor hypoxia augment SDT-induced highly toxic reactive species (ROS) production efficient cancer cell apoptosis. Importantly, generated heat by 808 nm laser irradiation accelerate catalytic elevate level further facilitates efficacy. Interestingly, thermally sensitive copolymer coated around act as smart switch regulate ability control TAPP release has significant on modulating effect. catalysis-enhanced efficiency almost realized complete resection obvious reoccurrence simultaneously displayed biosafety. Furthermore, high optical absorbance allows as-synthesized photoacoustic (PA) imaging NIR thermal imaging. This work develops versatile nanoplatform multifunctional theranostic strategy broadens biological designing their structure.

Language: Английский

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Ultrasound‐Activated Sensitizers and Applications

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(34), P. 14212 - 14233

Published: July 3, 2019

Modalities for photo-triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic (SDT), which is different from photodynamic (PDT) the use of highly penetrating acoustic waves to activate a class sound-responsive materials called sonosensitizers, has gained significant interest in recent years. The effect SDT closely related structural and physicochemical properties led development new sound-activated as sonosensitizers various biomedical applications. This Review provides summary discussion types novel developed last few years outlines specific designs potential challenges. applications with functions such imaging drug delivery well combination other treatment modalities would provide strategies disease therapy.

Language: Английский

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Peroxydisulfate Activation and Singlet Oxygen Generation by Oxygen Vacancy for Degradation of Contaminants

Environmental Science & Technology, Journal Year: 2021, Volume and Issue: 55(3), P. 2110 - 2120

Published: Jan. 11, 2021

Oxygen vacancies (OVs) play a crucial role in the catalytic activity of metal-based catalysts; however, their activation mechanism toward peroxydisulfate (PDS) still lacks reasonable explanation. In this study, by taking bismuth bromide (BiOBr) as an example, we report OV-mediated PDS process for degradation bisphenol A (BPA) employing singlet oxygen (1O2) main reactive species under alkaline conditions. The experimental results show that removal efficiency BPA is proportional to number OVs and highly related dosage catalyst. surface BiOBr provide ideal sites inclusion hydroxyl ions (HO-) form BiIII-OH species, which are regarded major active adsorption PDS. Unexpectedly, occurs through nonradical mediated 1O2, generated via multistep reactions, involving formation intermediate superoxide radical (O2•-) redox cycle Bi(III)/Bi(IV). This work dedicated in-depth study into over OV-rich samples provides novel perspective peroxides defective materials absence additional energy supply or aqueous transition metal ions.

Language: Английский

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Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications

Chemical Reviews, Journal Year: 2018, Volume and Issue: 119(3), P. 1666 - 1762

Published: Dec. 28, 2018

Organic/inorganic nanohybrids have attracted widespread interests due to their favorable properties and promising applications in biomedical areas. Great efforts been made design fabricate versatile nanohybrids. Among different organic components, diverse polymers offer unique avenues for multifunctional systems with collective properties. This review focuses on the design, properties, of organic/inorganic fabricated from inorganic nanoparticles polymers. We begin a brief introduction variety strategies fabrication functional Then functions are discussed, including parts, synergistic morphology-dependent self-assembly After that, current situations applied imaging, therapy, imaging-guided therapy demonstrated. Finally, we discuss prospect highlight challenges opportunities future investigations.

Language: Английский

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Ultrasound-Switchable Nanozyme Augments Sonodynamic Therapy against Multidrug-Resistant Bacterial Infection

ACS Nano, Journal Year: 2020, Volume and Issue: 14(2), P. 2063 - 2076

Published: Feb. 5, 2020

Ultrasound (US)-driven sonodynamic therapy (SDT) has demonstrated wide application prospects in the eradication of deep-seated bacterial infections due to its noninvasiveness, site-confined irradiation, and high-tissue-penetrating capability. However, ineffective accumulation sonosensitizers at infection site, hypoxic microenvironment, as well rapid depletion oxygen during SDT greatly hamper therapeutic efficacy SDT. Herein, an US-switchable nanozyme system was proposed for controllable generation catalytic sonosensitizer-mediated reactive species ultrasound activation, thereby alleviating hypoxia-associated barrier augmenting efficacy. This nanoplatform (Pd@Pt-T790) easily prepared by bridging enzyme-catalytic Pd@Pt nanoplates with organic sonosensitizer meso-tetra(4-carboxyphenyl)porphine (T790). It really interesting find that modification T790 onto could significantly block catalase-like activity Pd@Pt, whereas upon US effectively recovered catalyze decomposition endogenous H2O2 into O2. Such "blocking activating" enzyme particularly important decreasing potential toxicity side effects nanozymes on normal tissues realize active, controllable, disease-loci-specific behavior. Taking advantage this activity, outstanding sites, excellent biocompatibility, Pd@Pt-T790-based nanosystem successfully applied eradicate methicillin-resistant Staphylococcus aureus (MRSA)-induced myositis, progression noninvasively monitored photoacoustic imaging magnetic resonance imaging. The developed nanoenzyme provides a promising strategy actively, controllably, precisely.

Language: Английский

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Advanced biotechnology-assisted precise sonodynamic therapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(20), P. 11227 - 11248

Published: Jan. 1, 2021

Herein, we provide the enhancement of SDT effect through elaborate strategies including design and modification sonosensitizers, combination other therapy modalities, molecular imaging-guided for precise treatment.

Language: Английский

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A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(27)

Published: May 16, 2019

Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as local oxygen concentration plays an important role in generation cytotoxic singlet (1 O2 ). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal-organic frameworks (MOFs) is presented for situ endogenous to enhance PDT efficacy under bioimaging guidance. The NE constructed by first coating manganese-based MOFs with silica, followed facile annealing process ambient atmosphere. After removing silica shell and post-modifying polydopamine poly(ethylene glycol) improving biocompatibility, obtained loaded chlorin e6 (Ce6), commonly used photosensitizer PDT, high loading capacity. Upon through catalytic reaction between amount H2 , hypoxic tumor microenvironment relieved. Thus, Ce6-loaded serves -activated supplier increase significantly enhanced antitumor vitro vivo. In addition, also shows T2 -weighted magnetic resonance imaging ability its vivo tracking. This work presents interesting biomedical use MOF-derived multifunctional theranostic agent cancer therapy.

Language: Английский

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Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Language: Английский

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Recent progress in the design fabrication of metal-organic frameworks-based nanozymes and their applications to sensing and cancer therapy

Biosensors and Bioelectronics, Journal Year: 2019, Volume and Issue: 137, P. 178 - 198

Published: May 8, 2019

Language: Английский

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