ACS Applied Materials & Interfaces,
Journal Year:
2019,
Volume and Issue:
11(45), P. 41946 - 41956
Published: Oct. 22, 2019
A
nanoplatform
for
magnetic
resonance
imaging
guidance
and
oxygen
self-supplementing
photodynamic
therapy
(PDT)
was
constructed
on
the
basis
of
a
porous
metal-organic
framework
(PCN-222(Mn)),
which
built
by
simple
Mn-porphyrin
ligands
biocompatible
Zr4+
ions.
Because
good
dispersibility
Mn3+
in
open
high
water
affinity
channel,
PCN-222(Mn)
exhibits
longitudinal
relaxivity
∼35.3
mM-1
s-1
(1.0
T).
In
addition,
it
shows
catalytic
activity
conversion
endogenous
hydrogen
peroxide
into
oxygen,
thereby
improving
tumor
hypoxia
during
therapy.
The
intravenous
injection
tumor-bearing
mice
mode
provided
T1-weighted
contrast
site
effectively
inhibited
growth
upon
single-laser
irradiation.
findings
provide
insights
development
multifunctional
theranostic
nanoplatforms
based
components.
Polymers,
Journal Year:
2020,
Volume and Issue:
12(3), P. 580 - 580
Published: March 5, 2020
Poly(N-isopropylacrylamide)
(PNIPAM)-based
thermosensitive
hydrogels
demonstrate
great
potential
in
biomedical
applications.
However,
they
have
inherent
drawbacks
such
as
low
mechanical
strength,
limited
drug
loading
capacity
and
biodegradability.
Formulating
PNIPAM
with
other
functional
components
to
form
composited
is
an
effective
strategy
make
up
for
these
deficiencies,
which
can
greatly
benefit
their
practical
This
review
seeks
provide
a
comprehensive
observation
about
the
PNIPAM-based
composite
applications
so
guide
related
research.
It
covers
general
principles
from
materials
choice
hybridization
strategies
well
performance
improvement
by
focusing
on
several
application
areas
including
delivery,
tissue
engineering
wound
dressing.
The
most
include
incorporation
of
inorganic
nanoparticles
or
self-assembled
structures
give
linking
polymer
blocks
unique
properties
produce
copolymeric
hydrogels,
improve
enhancing
giving
higher
biocompatibility
biodegradability,
introducing
multi-stimuli
responsibility,
enabling
controlled
release.
These
aspects
will
be
help
promoting
development
Materials Today Bio,
Journal Year:
2019,
Volume and Issue:
5, P. 100035 - 100035
Published: Nov. 7, 2019
Cancer,
as
one
of
the
most
life-threatening
diseases,
shows
a
high
fatality
rate
around
world.
When
improving
therapeutic
efficacy
conventional
cancer
treatments,
researchers
also
conduct
extensive
studies
into
alternative
approaches,
which
are
safe,
valid,
and
economical.
Phototherapies,
including
photodynamic
therapy
(PDT)
photothermal
(PTT),
tumor-ablative
function-reserving
oncologic
interventions,
showing
strong
potential
in
clinical
treatment.
During
phototherapies,
non-toxic
phototherapeutic
agents
can
be
activated
upon
light
irradiation
to
induce
cell
death
without
causing
much
damage
normal
tissues.
Besides,
with
rapid
development
nanotechnology
past
decades,
phototheranostic
nanomedicine
has
attracted
tremendous
interests
aiming
continuously
refine
their
performance.
Herein,
we
reviewed
recent
progress
for
improved
therapy.
After
brief
introduction
principles
related
PDT
PTT,
existing
works
on
developing
by
mainly
focusing
categories
applications,
particularly
phototherapy-synergized
immunotherapy,
comprehensively
reviewed.
More
importantly,
conclusion
future
challenges
from
our
point
view
delivered
last
part
this
article.
Advanced Functional Materials,
Journal Year:
2018,
Volume and Issue:
29(4)
Published: Nov. 30, 2018
Abstract
The
concept
of
the
“supramolecular
photothermal
effects”
refers
to
collection
property
and
conversion
efficiency
resulting
from
supramolecular
assembly
molecular
sensitizers.
This
review
considers
organic
materials
assembled
at
nanoscale
via
various
self‐assembly
strategies
associated
with
organization
multiple
noncovalent
interactions.
In
these
materials,
individual
photosensitizer
molecules
are
typically
aggregated
through
in
a
certain
form
that
exhibits
enhanced
biostability,
increased
photoluminescence
quenching,
improved
therapeutic
effects
comparison
those
monomeric
molecules.
These
controlled
or
influenced
by
intermolecular
interactions,
especially
hydrophobic
effects,
which
distinct
mechanisms
conventional
sensitizer
polymers
inorganic
agents.
A
focus
lies
on
how
give
rise
including
polymer
protein
fabrication,
small
molecule
self‐assembly,
construction
donor–acceptor
binary
systems.
Emphases
placed
rational
design
nanomaterials,
drug
delivery,
vivo
effects.
Finally,
key
challenges
promising
prospects
nanomaterials
terms
both
technical
advances
clinical
translation
discussed.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
9(5)
Published: Dec. 19, 2021
Cancer
immunotherapy
has
achieved
promising
clinical
progress
over
the
recent
years
for
its
potential
to
treat
metastatic
tumors
and
inhibit
their
recurrences
effectively.
However,
low
patient
response
rates
dose-limiting
toxicity
remain
as
major
dilemmas
immunotherapy.
Stimuli-responsive
nanoparticles
(srNPs)
combined
with
offer
possibility
amplify
anti-tumor
immune
responses,
where
weak
acidity,
high
concentration
of
glutathione,
overexpressions
enzymes,
reactive
oxygen
species,
external
stimuli
in
act
triggers
controlled
drug
release.
This
review
highlights
design
srNPs
based
on
tumor
microenvironment
and/or
combine
different
drugs,
especially
immunoregulatory
agents,
which
eventually
realize
synergistic
malignant
primary
or
acquire
a
long-term
memory
prevent
recurrence.
The
authors
hope
that
this
can
provide
theoretical
guidance
construction
transformation
smart
delivery
cancer
Pharmaceutics,
Journal Year:
2019,
Volume and Issue:
11(1), P. 22 - 22
Published: Jan. 8, 2019
Theranostics
has
emerged
in
recent
years
to
provide
an
efficient
and
safer
alternative
cancer
management.
This
review
presents
updated
description
of
nanotheranostic
formulations
under
development
for
skin
(including
melanoma),
head
neck,
thyroid,
breast,
gynecologic,
prostate,
colon
cancers,
brain-related
cancer,
hepatocellular
carcinoma.
With
this
focus,
we
appraised
the
clinical
advantages
drawbacks
metallic,
polymeric,
lipid-based
nanosystems,
such
as
low
invasiveness,
toxicity
surrounding
healthy
tissues,
high
precision,
deeper
tissue
penetration,
dosage
adjustment
a
real-time
setting.
Particularly
recognizing
increased
complexity
multimodality
area,
multifunctional
hybrid
nanoparticles,
comprising
different
nanomaterials
functionalized
with
targeting
moieties
and/or
anticancer
drugs,
present
best
characteristics
theranostics.
Several
examples,
focusing
on
their
design,
composition,
imaging
treatment
modalities,
vitro
vivo
characterization,
are
detailed
herein.
Briefly,
all
studies
followed
common
trend
design
these
theranostics
use
materials
drugs
that
share
both
inherent
(e.g.,
contrast
agents)
therapeutic
properties
heating
or
production
reactive
oxygen
species).
rationale
allows
one
apparently
overcome
heterogeneity,
complexity,
harsh
conditions
tumor
microenvironments,
leading
successful
targeted
therapies.
ACS Nano,
Journal Year:
2019,
Volume and Issue:
13(11), P. 12638 - 12652
Published: Oct. 18, 2019
Photodynamic
therapy
(PDT)
is
a
clinical
cancer
treatment
modality
based
on
the
induction
of
therapeutic
reactive
oxygen
species
(ROS),
which
can
trigger
immunogenic
cell
death
(ICD).
With
aim
simultaneously
improving
both
PDT-mediated
intracellular
ROS
production
and
ICD
levels,
we
designed
serum
albumin
(SA)-coated
boehmite
("B";
aluminum
hydroxide
oxide)
organic-inorganic
scaffold
that
could
be
loaded
with
chlorin
e6
(Ce6),
photosensitizer,
honey
bee
venom
melittin
(MLT)
peptide,
denoted
Ce6/MLT@SAB.
Ce6/MLT@SAB
was
anchored
by
nanorod
structure
exhibited
particle
size
approximately
180
nm.
significantly
reduce
hemolysis
relative
to
free
MLT,
while
providing
MLT-enhanced
PDT
antitumor
effects
in
vitro.
Compared
Ce6@SAB,
improved
Ce6
penetration
cells
vitro
vivo,
thereby
enhanced
generation
660
nm
light
treatment.
Following
phototreatment,
Ce6/MLT@SAB-treated
displayed
levels
abilities
activate
dendritic
cells.
In
absence
laser
irradiation,
multidose
injection
delay
growth
subcutaneous
murine
tumors
more
than
60%,
compared
controls.
When
combined
single
phototreatment
eradicated
one-third
treated
mice.
The
addition
an
immune
checkpoint
blockade
further
augmented
effects,
generating
increased
numbers
CD4+
CD8+
T
concomitant
reduction
myeloid-derived
suppressor
ACS Applied Materials & Interfaces,
Journal Year:
2019,
Volume and Issue:
11(33), P. 29579 - 29592
Published: July 30, 2019
Tumor
hypoxia
and
the
short
half-life
of
reactive
oxygen
species
(ROS)
with
small
diffusion
distance
have
greatly
limited
therapeutic
effect
photodynamic
therapy
(PDT).
Here,
a
multifunctional
nanoplatform
is
developed
to
enhance
PDT
through
increasing
concentration
in
tumor
cells
by
Fenton
reaction
reducing
between
ROS
target
site
mitochondrial
targeting.
Fe3O4@Dex-TPP
nanoparticles
are
first
prepared
coprecipitation
presence
triphenylphosphine
(TPP)-grafted
dextran
(Dex-TPP)
Fe2+/Fe3+,
which
magnetic
resonance
imaging
effect.
Next,
photosensitizers
protoporphyrin
IX
(PpIX)
glutathione-responsive
mPEG-ss-COOH
grafted
on
form
Fe3O4@Dex/TPP/PpIX/ss-mPEG
nanoparticles.
After
internalized,
part
Fe3O4
decomposed
into
Fe2+/Fe3+
acidic
lysosome
then
diffused
cytoplasm,
subsequently,
Fe2+
reacted
overproduced
H2O2
produce
O2
•OH.
The
undecomposed
enter
cytoplasm
photoinduced
internalization
targeted
mitochondria,
leading
direct
generation
around
mitochondria.
Simultaneously,
produced
can
serve
as
raw
material
for
continuously
exert
As
result,
reaction-assisted
significantly
improve
efficacy
tumors.
