Recent advances and clinical translation of liposomal delivery systems in cancer therapy

European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 193, P. 106688 - 106688

Published: Jan. 1, 2024

The limitations of conventional cancer treatment are driving the emergence and development nanomedicines. Research in liposomal nanomedicine for therapy is rapidly increasing, opening up new horizons treatment. Liposomal nanomedicine, which focuses on targeted drug delivery to improve therapeutic effect while reducing damage normal tissues cells, has great potential field therapy. This review aims clarify advantages systems We describe recent understanding spatiotemporal fate liposomes organism after different routes administration. Meanwhile, various types liposome-based that exert their respective side effects were discussed. Moreover, combination agents with other therapies (such as photodynamic photothermal therapy) demonstrated enhanced tumor-targeting efficiency efficacy. Finally, opportunities challenges faced by liposome nanoformulations entering clinical highlighted.

Language: Английский

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Recent updates and feasibility of nanodrugs in the prevention and eradication of dental biofilm and its associated pathogens—A review

Journal of Dentistry, Journal Year: 2024, Volume and Issue: 143, P. 104888 - 104888

Published: Feb. 9, 2024

Language: Английский

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New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 4, 2024

Abstract Periodontitis is a chronic inflammatory disease caused by the local microbiome and host immune response, resulting in periodontal structure damage even tooth loss. Scaling root planning combined with antibiotics are conventional means of nonsurgical treatment periodontitis, but they insufficient to fully heal periodontitis due intractable bacterial attachment drug resistance. Novel effective therapeutic options clinical therapy remain scarce. Nanotherapeutics achieve stable cell targeting, oral retention smart release great flexibility changing chemical composition or physical characteristics nanoparticles. Meanwhile, protectiveness high surface area volume ratio nanoparticles enable loading, ensuring remarkable efficacy. Currently, combination advanced novel strategies most active research treatment. In this review, we first introduce pathogenesis then summarize state-of-the-art nanotherapeutic based on triple concerto antibacterial activity, immunomodulation periodontium regeneration, particularly focusing mechanism ingenious design nanomedicines. Finally, challenges prospects nano for discussed from perspective current problems future development trends. Graphical

Language: Английский

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Strategies to Promote the Journey of Nanoparticles Against Biofilm‐Associated Infections

Small, Journal Year: 2024, Volume and Issue: 20(10)

Published: Jan. 4, 2024

Abstract Biofilm‐associated infections are one of the most challenging healthcare threats for humans, accounting 80% bacterial infections, leading to persistent and chronic infections. The conventional antibiotics still face their dilemma poor therapeutic effects due high tolerance resistance led by biofilm barriers. Nanotechnology‐based antimicrobials, nanoparticles (NPs), paid attention extensively considered as promising alternative. This review focuses on whole journey NPs against biofilm‐associated clarify it clearly, is divided into four processes in sequence 1) Targeting biofilms, 2) Penetrating barrier, 3) Attaching cells, 4) Translocating through cell envelope. Through outlining compositions properties biofilms bacteria recent advances present strategies each process comprehensively discussed combat well combined these with drug resistance, aiming guide rational design facilitate wide application

Language: Английский

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Treatment of dental biofilm-forming bacterium Streptococcus mutans using tannic acid-mediated gold nanoparticles

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 189, P. 106568 - 106568

Published: Feb. 13, 2024

Language: Английский

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Nanozybiotics: Advancing Antimicrobial Strategies Through Biomimetic Mechanisms

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 14, 2024

Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.

Language: Английский

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Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3273 - 3301

Published: Jan. 1, 2024

Oral diseases are prevalent but challenging owing to the highly movable and wet, microbial inflammatory environment. Polymeric materials regarded as one of most promising biomaterials due their good compatibility, facile preparation, flexible design obtain multifunctionality. Therefore, a variety strategies have been employed develop with improved therapeutic efficacy by overcoming physicobiological barriers in oral diseases. In this review, we summarize polymeric for treatment First, present unique environment including environment, which hinders effective Second, series designing towards such highlighted. For example, multifunctional armed wet-adhesive, antimicrobial, anti-inflammatory functions through advanced chemistry nanotechnology effectively treat These achieved wet-adhesive polymers modified hydroxy, amine, quinone, aldehyde groups provide strong wet-adhesion hydrogen covalent bonding, electrostatic hydrophobic interactions, developing antimicrobial cationic polymers, peptides, antibiotic-conjugated synthesizing phenolic hydroxy cysteine that function immunomodulators electron donors reactive oxygen species reduce inflammation. Third, various delivery systems enhanced mucosa biofilm penetration capabilities, nanoparticles, hydrogels, patches, microneedles, constructed antibiotics, immunomodulators, antioxidants achieve efficacy. Finally, insights into challenges future development promise clinical translation.

Language: Английский

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Charge Regulation-Enhanced Type I Photosensitizer-Loaded Hydrogel Dressing for Hypoxic Bacterial Inhibition and Biofilm Elimination

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Biofilm-induced chronic bacterial infections represent a significant challenge in modern medicine due to their resistance conventional antibiotic treatments. Although photodynamic therapy (PDT) has emerged as promising antibiotic-free antibacterial strategy, the hypoxic condition within biofilms and lack of an effective local drug delivery system have limited clinical effectiveness photosensitizer (PS) agents. Herein, we propose type charge regulation-enhanced I PS-loaded hydrogel dressing for treating biofilm infection. The regulation enables multiple alkylation Nile blue (EB series) exhibit substantially improved absorbance (∼2-fold), alkaline tolerance, superoxide anion yield (2.2-4.2-fold) compared representative PS, sulfur-substituted blue. Specifically, enhanced electronic push-pull capabilities promote more efficient electron recycling process, significantly boosting efficiency PDT. superior PDT effect uptake via render EB series pronounced inhibition under red light or sunlight irradiation. Moreover, hydrogel, constructed from oxidized dextran quaternized chitosan, facilitates localization sustained retention PSs, accelerating healing biofilm-infected wounds. This PS-based could provide user-friendly wound treatment prevention infections.

Language: Английский

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Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections

Research, Journal Year: 2020, Volume and Issue: 2020

Published: Jan. 1, 2020

The formation of bacterial biofilms closely associates with infectious diseases. Until now, precise diagnosis and effective treatment biofilm infections are still in great need. Herein, a novel multifunctional theranostic nanoplatform based on MnO2 nanosheets (MnO2 NSs) has been designed to achieve pH-responsive dual-mode imaging hypoxia-relief-enhanced antimicrobial photodynamic therapy (aPDT) infections. In this study, NSs were modified bovine serum albumin (BSA) polyethylene glycol (PEG) then loaded chlorin e6 (Ce6) as photosensitizer form MnO2-BSA/PEG-Ce6 (MBP-Ce6 NSs). After being delivered into the biofilm-infected tissues, MBP-Ce6 could be decomposed acidic microenvironment release Ce6 Mn2+, which subsequently activate both fluorescence (FL) magnetic resonance (MR) signals for FL/MR Meanwhile, catalyze decomposing H2O2 tissues O2 relieve hypoxic condition biofilm, significantly enhances efficacy aPDT. An vitro study showed that reduce number methicillin-resistant Staphylococcus aureus (MRSA) after 635 nm laser irradiation. Guided by imaging, MRSA mice can efficiently treated NSs-based Overall, not only possess microenvironment-responsive ability but also have enhanced aPDT relieving hypoxia habitat provides promising

Language: Английский

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Recent development of nanomedicine for the treatment of bacterial biofilm infections

View, Journal Year: 2020, Volume and Issue: 2(1)

Published: Oct. 14, 2020

Abstract Bacterial biofilm related infections are ever growing issues for global medical community. Traditional antibiotic therapy is usually ineffective treating them because the bacteria inside biofilms have evolved with multiple mechanisms to evade challenge. Hence, effective therapeutic strategy novel antibiofilm mode of action highly desired. In this context, nanomedicine has drawn great attentions and been proven promising prevent eliminate bacterial biofilms. review, we focus on recent advance nanotechnology‐based strategies nanoagents combating infections. First, typical nanotechnologies utilized different chemical, physical, biological properties nanomaterials discussed. Second, smart that can responsive microenvironment, including pH, H 2 O , enzymes, shown. Third, some approaches, such as theranostics, structure destruction, quorum sensing inhibition, also demonstrated. Finally, conclude current discuss challenges future directions in field.

Language: Английский

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