Langmuir,
Journal Year:
2021,
Volume and Issue:
37(44), P. 12842 - 12852
Published: Oct. 27, 2021
Metal
ion-induced
peptide
assembly
is
an
interesting
field.
As
compared
to
traditional
antibacterial
Ag+,
rare
earth
metal
ions
possess
the
advantage
of
performance
with
photostability
and
low
toxicity.
Herein,
a
new
Fmoc-FFWDD-OH
was
designed
synthesized,
which
could
form
stable
hydrogel
induced
by
ions,
including
Tb3+,
Eu3+,
La3+.
The
mechanical
properties
were
characterized
rheological
measurements,
they
exhibited
elasticity-dominating
properties.
Transmission
electron
microscopy
(TEM)
images
showed
large
number
nanoscale
fiber
structures
formed
in
hydrogel.
Circular
dichroism
(CD)
spectra,
Fourier
transform
infrared
(FT-IR)
ThT
assays,
X-ray
diffraction
(XRD)
pattern
illustrated
formation
mechanism
structure.
proved
good
on
Escherichia
coli
(E.
coli)
excellent
biocompatibility.
introduction
may
have
some
potential
applications
biological
medical
fields.
Soft Matter,
Journal Year:
2020,
Volume and Issue:
16(6), P. 1404 - 1454
Published: Jan. 1, 2020
Herein,
very
recent
advances
in
polymer,
peptide,
and
hybrid
hydrogels
for
uses
photovoltaics,
supercapacitor,
organic
electronics,
drug
delivery,
tissue
engineering,
biosensing,
cell
culture,
different
optoelectronic
materials
are
discussed.
Abstract
Due
to
their
similarity
some
bio‐architectures,
for
example,
extracellular
matrix,
hydrogels
are
considered
as
bio‐inspired
networks
with
bio‐mimetic
and
bio‐functional
properties.
With
natural
cytocompatibility
biocompatibility,
nowadays
more
involved
in
various
bio‐applications
including
shape
morphing,
artificial
muscles,
soft
robotics,
regenerative
medicine,
so
on.
As
an
important
subclass,
stimuli‐responsive
have
been
attracting
interest
within
decades.
In
response
single
or
multi‐triggers
biological
microenvironment,
can
undergo
phase
transition,
stiffness
change,
biochemical
properties
activation,
which
make
them
intriguing
biomaterials
broad
applications
sensing,
drug
delivery,
tissue
engineering,
wound
healing.
This
review
presents
typical
synthetic
gelators
comprising
small
molecules
polymers
building
blocks
of
functional
architectures.
The
fabrication
strategies
varied
from
supramolecular
assembly
dynamic
covalent
binding
detailed.
Various
exogenous
endogenous,
physical
chemical,
stimuli
together
mechanism,
design
principle
demonstrated.
Through
recent
examples
different
perspectives,
such
bionic
devices,
dressing,
cargo
carrier,
the
benefits
opportunities
highlighted.
Finally,
current
challenges
future
prospects
view
translation
fundamental
researches
clinical
application
briefly
discussed.
Accounts of Chemical Research,
Journal Year:
2024,
Volume and Issue:
57(3), P. 289 - 301
Published: Jan. 17, 2024
ConspectusBiomolecular
self-assembly
is
a
ubiquitous
occurrence
in
nature
that
gives
rise
to
sophisticated
superstructures
enable
the
implementation
of
complex
biological
functions.
It
encompasses
both
ordered
structures,
such
as
DNA
double
helix,
and
disordered
nucleolus
other
nonmembranous
organelles.
In
contrast
these
highly
organized
which
exhibit
specific
patterns
or
symmetry,
structures
are
characterized
by
their
flexible
randomized
molecular
organization,
provides
versatility,
dynamicity,
adaptability
systems
contributes
complexity
functionality
living
organisms.
However,
usually
exist
thermodynamically
metastable
state.
This
means
unstable
difficult
observe
due
short
existence
time.
Achieving
through
precise
control
assembly
process
ensuring
stability
integrity
pose
significant
challenges.
Currently,
ongoing
research
efforts
focused
on
proteins
with
intrinsically
regions
(IDRs).
structural
instability
present
prohibitive
difficulties
elucidating
multiscale
process.
Therefore,
simple
peptides,
segment
proteins,
hold
great
promise
constructing
for
related
research.
Since
our
finding
droplet-like
occur
transiently
during
peptide
(PSA),
centered
around
dynamic
evolution
supramolecular
systems,
particularly
modulation
variety
assembled
ranging
from
disordered.In
this
Account,
we
narrate
recent
endeavors
formed
PSA,
spanning
structures.
We
delve
into
mechanisms
regulation,
shedding
light
how
peptide-based
can
be
controlled
more
precisely.
Moreover,
emphasize
functional
applications
arise
To
begin,
conduct
comprehensive
overview
various
types
emerge
showcasing
diverse
applications.
Following,
elaborate
discovery
development
PSA.
A
mechanistic
study
multistep
processes
mediated
liquid–liquid
phase
separation
(LLPS)
critically
emphasized.
Ordered
different
morphologies
functions
obtained
subtly
controlling
adjusting
liquid
droplets.
particular,
have
recently
developed
solid
glasses
long-range
disorder,
including
noncovalent
biomolecular
glass
based
amino
acid
derivatives,
well
high-entropy
cyclic
peptides.
demonstrates
potential
using
biologically
derived
molecules
create
green
sustainable
glassy
materials.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(2), P. 384 - 409
Published: Feb. 3, 2023
The
self-assembly
and
structural
functional
properties
of
peptide
conjugates
containing
bulky
terminal
aromatic
substituents
are
reviewed
with
a
particular
focus
on
bioactivity.
Terminal
moieties
include
Fmoc
[fluorenylmethyloxycarbonyl],
naphthalene,
pyrene,
naproxen,
diimides
naphthalene
or
others.
These
provide
driving
force
for
due
to
π-stacking
hydrophobic
interactions,
in
addition
the
hydrogen
bonding,
electrostatic,
other
forces
between
short
peptides.
balance
these
interactions
leads
propensity
self-assembly,
even
single
amino
acids.
hybrid
molecules
often
form
hydrogels
built
from
network
β-sheet
fibrils.
as
biomaterials
support
cell
culture,
development
that
can
assemble
cells
(in
response
cellular
enzymes,
otherwise)
range
fascinating
bioactivities
such
anticancer
antimicrobial
activity,
highlighted.
In
addition,
applications
slow-release
drug
delivery
systems
catalysis
discussed.
nature
also
provides
diversity
interesting
optoelectronic
have
been
demonstrated
literature,
an
overview
this
is
provided.
Also
discussed
coassembly
enzyme-instructed
which
enable
precise
tuning
(stimulus-responsive)
functionalization
nanostructures.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 2, 2024
Abstract
Assembly
ubiquitously
occurs
in
nature
and
gives
birth
to
numerous
functional
biomaterials
sophisticated
organisms.
In
this
work,
chiral
hydrogen-bonded
organic-inorganic
frameworks
(HOIFs)
are
synthesized
via
biomimicking
the
self-assembly
process
from
amino
acids
proteins.
Enjoying
homohelical
configurations
analogous
α
-helix,
HOIFs
exhibit
remarkable
chiroptical
activity
including
fluorescence
(
g
lum
=
1.7
×
10
−3
)
that
is
untouched
among
previously
reported
frameworks.
Benefitting
dynamic
feature
of
hydrogen
bonding,
enable
enantio-discrimination
aliphatic
substrates
with
imperceivable
steric
discrepancy
based
on
fluorescent
change.
Moreover,
disassembled
after
recognition
applications
capable
being
facilely
regenerated
self-purified
aprotic
solvent-induced
reassembly,
leading
at
least
three
consecutive
cycles
without
losing
enantioselectivity.
The
underlying
mechanism
chirality
bias
decoded
by
experimental
isothermal
titration
calorimetry
together
theoretic
simulation.
