Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects DOI
Xianlong Zhang, Guoliang Li, Guang Chen

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(50)

Published: Sept. 8, 2021

Abstract Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits these cascade systems, enormous efforts have been devoted to developing novel systems mimic reactions over past few years. Nanozymes, a class enzyme mimics, are nanomaterials with enzyme‐like activity. The emergence development nanozymes has significantly advanced biomimetic nanoreactors. Currently, nanoreactors driven widely used exhibit many advantages such as superior efficiency high stability, resulting significant advancements biosensing biomedical applications. latest advances understanding mechanism nanozyme‐engineered their progressive applications for comprehensively covered here. First, nanozyme enzyme/nanozyme‐engineered categorized according properties. Then, applications, including cancer therapy, antibacterial activity, antioxidation, hyperuricemia therapy covered. conclusion describes most important challenges opportunities remaining this exciting area research.

Language: Английский

Immunogenic Cell Death Augmented by Manganese Zinc Sulfide Nanoparticles for Metastatic Melanoma Immunotherapy DOI
Zhu Li,

Zhaoyou Chu,

Juan Yang

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(9), P. 15471 - 15483

Published: Aug. 18, 2022

Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of immune-mediated destruction in melanoma. In this work, an amphiphilic polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane) copolymer with a thermally sensitive flowable core (mPEG-b-PHEP) was chosen to incorporate IR780 dye manganese zinc sulfide nanoparticles (ZMS) form polymer micelles (denoted PPIR780-ZMS), which precisely controlled release ZMS after being triggered by near-infrared light (NIR). Mn2+-mediated chemodynamic therapy (CDT) photothermal trigger boosted generation reactive oxygen species (ROS), making PPIR780-ZMS smart bomblets vivo. It demonstrated that could maximize immunogenic cell death (ICD) cancer, is characterized abundant damage-associated molecular pattern (DAMP) exposure. As result, cytotoxic T cells (CD8+) helper (CD4+) expanded infiltrated neoplastic foci, further reprogrammed suppressive microenvironment (TME) against primary pulmonary metastases safe systemic cytokine expression. addition, cGAS-STING signaling pathway activation enhanced antitumor immunity nanocomposite, providing practical strategy for expanding use Mn-based nanostructures.

Language: Английский

Citations

143
Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy DOI
Qianqian Sun, Zhao Wang, Bin Liu

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 451, P. 214267 - 214267

Published: Nov. 6, 2021

Language: Английский

Citations

140
Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy DOI

Zhaoyou Chu,

Juan Yang, Zheng Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 481, P. 215049 - 215049

Published: Feb. 9, 2023

Language: Английский

Citations

125
Interfacially Engineered ZnxMn1–xS@Polydopamine Hollow Nanospheres for Glutathione Depleting Photothermally Enhanced Chemodynamic Therapy DOI

Juan Ruan,

Hang Liu,

Benjin Chen

et al.

ACS Nano, Journal Year: 2021, Volume and Issue: 15(7), P. 11428 - 11440

Published: June 21, 2021

Fenton-like reactions driven by manganese-based nanostructures have been widely applied in cancer treatment owing to the intrinsic physiochemical properties of these and their improved sensitivity tumor microenvironment. In this work, ZnxMn1–xS@polydopamine composites incorporating alloyed ZnxMn1–xS polydopamine (PDA) were constructed, which Mn ions can be tuned a controllable release vitro vivo. As result, ZnxMn1–xS@PDA exhibited good biocompatibility with normal cells but was specifically toxic cells. addition, shell thickness PDA carefully investigated obtain excellent specific toxicity promote synergistic chemodynamic photothermal therapies. Overall, work highlights an alternative strategy for fabricating high-performance, multifunctional composite combined treatment.

Language: Английский

Citations

124
Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects DOI
Xianlong Zhang, Guoliang Li, Guang Chen

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(50)

Published: Sept. 8, 2021

Abstract Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits these cascade systems, enormous efforts have been devoted to developing novel systems mimic reactions over past few years. Nanozymes, a class enzyme mimics, are nanomaterials with enzyme‐like activity. The emergence development nanozymes has significantly advanced biomimetic nanoreactors. Currently, nanoreactors driven widely used exhibit many advantages such as superior efficiency high stability, resulting significant advancements biosensing biomedical applications. latest advances understanding mechanism nanozyme‐engineered their progressive applications for comprehensively covered here. First, nanozyme enzyme/nanozyme‐engineered categorized according properties. Then, applications, including cancer therapy, antibacterial activity, antioxidation, hyperuricemia therapy covered. conclusion describes most important challenges opportunities remaining this exciting area research.

Language: Английский

Citations

121