Biomaterials Science,
Journal Year:
2020,
Volume and Issue:
9(1), P. 10 - 22
Published: May 22, 2020
Endowing
the
surfaces
of
synthetic
materials
with
bactericidal
activity
is
a
direct
and
effective
way
to
prevent
bacterial
colonization
biofilm
formation,
solving
related
serious
problems
such
as
contamination,
infection
biofouling.
Conventional
are
usually
based
on
biocidal
agents
antibiotics
kill
attached
bacteria;
however,
have
inherent
limitations
from
their
respective
most
them
become
less
against
so-called
"super
bacteria"
multidrug-resistance.
In
recent
years,
photothermal
promising
alternative
for
combating
surface-attached
bacteria.
These
rely
immobilized
agents,
which
can
convert
light
energy
into
thermal
effectively
eliminate
bacteria
through
various
hyperthermia
effects,
showing
several
advantages
including
broad-spectrum
sterilization
ability,
no
drug
resistance
few
side
effects.
this
review,
we
highlight
development
these
surfaces,
categorized
three
types
according
agents.
Multi-functional
either
integrated
synergistic
killing
mechanisms
or
capability
switch
function
between
releasing
also
introduced.
A
brief
perspective
finally
presented
directions
that
show
promise
future.
Nano Letters,
Journal Year:
2020,
Volume and Issue:
20(10), P. 7350 - 7358
Published: Aug. 28, 2020
Increasing
penetration
of
antibacterial
agents
into
biofilm
is
a
promising
strategy
for
improvement
therapeutic
effect
and
slowdown
the
progression
antibiotic
resistance.
Herein,
we
design
near-infrared
(NIR)
light-driven
nanoswimmer
(HSMV).
Under
NIR
light
irradiation,
HSMV
performs
efficient
self-propulsion
penetrates
within
5
min
due
to
photothermal
conversion
asymmetrically
distributed
AuNPs.
The
localized
thermal
(∼45
°C)
thermal-triggered
release
vancomycin
(Van)
leads
an
combination
therapy
chemotherapy
in
one
system.
active
motion
increases
effective
distance
(PTT)
also
improves
index
antibiotic,
resulting
superior
removal
rate
(>90%)
vitro.
Notably,
can
eliminate
S.
aureus
biofilms
grown
vivo
under
10
laser
irradiation
without
damage
healthy
tissues.
This
work
may
shed
on
strategies
treatment
biofilm-associated
infections.
ACS Applied Polymer Materials,
Journal Year:
2021,
Volume and Issue:
3(5), P. 2233 - 2263
Published: April 20, 2021
One
of
the
most
detrimental
consequences
surface
colonization
by
bacteria
is
healthcare-associated
infections
(HAIs),
which
contribute
to
increased
patient
mortality
and
morbidity.
Medical
devices
inserted
into
body
provide
a
route
for
bacterial
migration
conducive
surfaces
their
attachment
proliferation.
Antibacterial
coatings
can
potentially
minimize
consequently
reduce
occurrence
HAIs.
function
either
inhibiting
(antifouling
coatings)
or
killing
attached
and/or
in
vicinity
(bactericidal
coatings).
On
an
antifouling
coating,
any
bacterium
that
manages
attach
will
proliferate,
while
on
bactericidal
coatings,
accumulation
dead
debris
provides
opportunities
other
colonize
surface.
As
such,
integration
functionalities
single
coating
combines
advantages
each,
increasing
probability
be
successfully
inhibited.
This
Review
highlights
recent
developments
dual-functional
polymer-based
antibacterial
specific
biomedical
applications.
General
strategies
endowing
with
polymeric
are
first
discussed,
followed
more
detailed
descriptions
integrated
target
important
applications:
blood-contacting
devices,
orthopedic
implants,
wound
dressings,
ocular
urinary
catheters,
endotracheal
tubes,
hospital
textiles.
The
importance
tailoring
meet
constraints
requirements
intended
application
beyond
functionality
emphasized,
finally,
potential
challenges
translating
such
clinical
highlighted.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(7), P. 10066 - 10087
Published: July 1, 2022
Antibiotic
resistance
has
become
a
serious
threat
to
human
health
due
the
overuse
of
antibiotics.
Different
antibiotics
are
being
developed
treat
resistant
bacteria,
but
development
cycle
is
hard
keep
up
with
high
incidence
antibiotic
resistance.
Recent
advances
in
antimicrobial
nanomaterials
have
made
nanotechnology
powerful
solution
this
dilemma.
Among
these
nanomaterials,
gold
excellent
antibacterial
efficacy
and
biosafety,
making
them
alternatives
This
review
presents
strategies
that
use
combat
drug-resistant
bacteria.
We
focus
on
influence
physicochemical
factors
such
as
surface
chemistry,
size,
shape
their
properties
describe
applications
medical
devices.
Finally,
existing
challenges
future
directions
discussed.
Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
10(14), P. 2296 - 2315
Published: Jan. 1, 2022
Tannic
acid-based
bioinspired
coating
strategies
for
tethering
functional
materials
or
molecules
on
different
medical
substrates
resisting
bacterial
pathogens
and
fouling
agents.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(31)
Published: June 7, 2023
Abstract
Due
to
the
emergence
of
drug
resistance
in
bacteria
and
biofilm
protection,
achieving
a
satisfactory
therapeutic
effect
for
bacteria‐infected
open
wounds
with
conventional
measures
is
problematic.
Here,
photothermal
cascade
nano‐reactor
(CPNC@GOx‐Fe
2+
)
constructed
through
supramolecular
strategy
hydrogen
bonding
coordination
interactions
between
chitosan‐modified
palladium
nano‐cube
(CPNC),
glucose
oxidase
(GOx),
ferrous
iron
(Fe
).
CPNC@GOx‐Fe
exhibits
excellent
effects
powers
GOx‐assisted
reaction
generate
hydroxyl
radicals,
enabling
chemodynamic
combination
therapy
against
biofilms.
Further
proteomics,
metabolomics,
all‐atom
simulation
results
indicate
that
damage
radical
function
structure
cell
membrane
thermal
enhance
fluidity
inhomogeneity
bacterial
membrane,
resulting
synergistic
antibacterial
effect.
In
biofilm‐associated
tooth
extraction
wound
model,
generated
from
process
can
initiate
polymerization
form
hydrogel
situ
protection.
vivo
experiments
confirm
protection
accelerate
healing
infected
tooth‐extraction
without
affecting
oral
commensal
microbiota.
This
study
provides
way
propose
multifunctional
system
treatment
infection.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(16)
Published: March 27, 2022
Photothermal
therapy
based
on
conjugated
polymers
represents
a
promising
antibacterial
strategy
but
still
possesses
notable
limitations.
Herein,
degradable
pseudo
(PCPs)
containing
photothermal
molecular
backbones
and
reactive
oxygen
species
(ROS)-sensitive
thioketal
bonds
are
designed.
Triphenylphosphine
(PPh
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(21), P. 22106 - 22120
Published: Oct. 30, 2023
Diabetic
wounds
represent
a
persistent
global
health
challenge
with
substantial
impact
on
patients'
and
overall
well-being.
Herein,
hydrogel
system
that
integrates
functionalized
gold
nanorods
(AuNRs)
M2
macrophage-derived
exosomes
(M2-Exos)
was
developed
to
achieve
an
efficient
synergistic
therapy
for
diabetic
wounds.
We
introduced
ion-cross-linked
dissipative
network
into
prefabricated
covalent
cross-linked
(long-chain
polymer
network),
which
prepared
using
AuNRs
as
specific
cross-linker.
The
ion
then
the
long-chain
in
situ
form
structure,
imparting
antiswelling
photothermal
effects
hydrogel.
This
integrated
effectively
scavenged
reactive
oxygen
species
levels,
inhibited
inflammation,
promoted
angiogenesis,
stimulated
antibacterial
activity
through
near-infrared
(NIR)
irradiation.
To
demonstrate
potential
of
hydrogel,
we
established
experimental
animal
models
oral
mucosa
ulceration
full-thickness
skin
defects.
In
vivo
results
confirmed
M2-Exos
released
from
hydrogels
played
crucial
role
wound
closure.
Furthermore,
effect
NIR
eradicated
bacterial
infections
area.
Overall,
our
is
promising
tool
accelerating
chronic
healing
tissue
regeneration.
study
highlights
benefits
combining
bioactive
platform
satisfactory
patients
diabetes.
