Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
12(3), P. 530 - 563
Published: Nov. 7, 2023
Wearable
devices
have
become
prevalent
in
biomedical
studies
due
to
their
convenient
portability
and
potential
utility
biomarker
monitoring
for
healthcare.
Accessing
interstitial
fluid
(ISF)
across
the
skin
barrier,
microneedle
(MN)
is
a
promising
minimally
invasive
wearable
technology
transdermal
sensing
drug
delivery.
MN
has
overcome
limitations
of
conventional
administration,
making
it
another
prospective
mode
delivery
after
oral
injectable.
Subsequently,
combining
with
multiple
approaches
led
its
extensive
application
detect
biomarkers
ISF.
In
this
context,
employing
platforms
control
schemes
merge
diagnostic
therapeutic
capabilities
into
theranostic
systems
will
facilitate
on-demand
therapy
point-of-care
diagnostics,
paving
way
future
technologies.
A
comprehensive
analysis
growing
advances
microneedles
presented
review
summarize
latest
academics
field
offer
reference
issues
that
need
be
addressed
Covering
an
array
novel
studies,
we
discuss
following
main
topics:
classification
field,
considerations
design,
current
applications
diagnosis
therapy,
regulatory
landscape
prospects
applications.
This
sheds
light
on
significance
microneedle-based
innovations,
presenting
implications
contributions
community
healthcare
The
provides
understanding
field's
state
potential,
valuable
resource
clinicians
seeking
harness
full
Advanced Healthcare Materials,
Journal Year:
2022,
Volume and Issue:
11(10)
Published: Jan. 16, 2022
Abstract
Theranostic
system
combined
diagnostic
and
therapeutic
modalities
is
critical
for
the
real‐time
monitoring
of
disease‐related
biomarkers
personalized
therapy.
Microneedles,
as
a
multifunctional
platform,
are
promising
transdermal
diagnostics
drug
delivery.
They
have
shown
attractive
properties
including
painless
skin
penetration,
easy
self‐administration,
prominent
effects,
good
biosafety.
Herein,
an
overview
microneedles‐based
diagnosis,
therapies,
theranostic
systems
given.
Four
detection
methods
concluded
based
on
sensing
mechanism:
i)
electrochemistry,
ii)
fluorometric,
iii)
colorimetric,
iv)
Raman
methods.
Additionally,
robust
microneedles
suitable
implantable
Microneedles‐assisted
delivery
can
be
primarily
classified
passive,
active,
responsive
release,
release
mechanisms.
oral
mechanisms
also
presented
in
this
review.
Furthermore,
key
frontier
developments
microneedles‐mediated
major
selling
points
emphasized
These
into
open‐loop
closed‐loop
indirectness
directness
feedback
between
diagnosis
therapy,
respectively.
Finally,
conclusions
future
perspectives
next‐generation
discussed.
Taken
together,
microneedle‐based
new
avenue
disease‐specific
applications.
Lab on a Chip,
Journal Year:
2023,
Volume and Issue:
23(5), P. 869 - 887
Published: Jan. 1, 2023
This
review
summarizes
state-of-the-art
microneedle-based
detection
and
sensing
systems,
highlighting
the
objective
significance,
principles,
systematic
construction,
validation
models
of
these
microneedles.
Small,
Journal Year:
2023,
Volume and Issue:
19(51)
Published: March 22, 2023
The
rapid
development
of
wearable
biosensing
calls
for
next-generation
devices
that
allow
continuous,
real-time,
and
painless
monitoring
health
status
along
with
responsive
medical
treatment.
Microneedles
have
exhibited
great
potential
the
direct
access
dermal
interstitial
fluid
(ISF)
in
a
minimally
invasive
manner.
Recent
studies
microneedle-based
evolved
from
conventional
off-line
detection
to
multiplexed,
wireless,
integrated
sensing.
In
this
review,
classification
fabrication
techniques
microneedles
are
first
introduced,
then
representative
examples
transdermal
different
sensing
modalities
summarized.
State-of-the-art
advances
therapeutic
closed-loop
systems
presented
formulate
guidelines
healthcare
platforms.
challenges
prospects
discussed
pave
new
avenue
toward
pragmatic
applications
real
world.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(12)
Published: Jan. 15, 2024
Abstract
Point‐of‐care
(POC)
has
the
capacity
to
support
low‐cost,
accurate
and
real‐time
actionable
diagnostic
data.
Microneedle
sensors
have
received
considerable
attention
as
an
emerging
technique
evolve
blood‐based
diagnostics
owing
their
direct
painless
access
a
rich
source
of
biomarkers
from
interstitial
fluid.
This
review
systematically
summarizes
recent
innovations
in
microneedle
with
particular
focus
on
utility
POC
personalized
medicine.
The
integration
various
sensing
techniques,
mostly
electrochemical
optical
sensing,
been
established
diverse
architectures
“lab‐on‐a‐microneedle”
platforms.
tailored
geometries,
mechanical
flexibility,
biocompatibility
are
constructed
variety
materials
fabrication
methods.
Microneedles
categorized
into
four
types:
metals,
inorganics,
polymers,
hydrogels,
elaborated
state‐of‐the‐art
bioengineering
strategies
for
minimally
invasive,
continuous,
multiplexed
sensing.
employed
detect
wide
range
electrolytes,
metabolites,
polysaccharides,
nucleic
acids,
proteins
drugs.
Insightful
perspectives
outlined
biofluid,
microneedles,
biosensors,
devices,
theragnostic
instruments,
which
depict
bright
future
upcoming
intelligent
health
management.
Communications Materials,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: March 13, 2024
Abstract
Interstitial
fluid
(ISF),
a
biological
rich
in
diverse
biomarkers
and
analytes
similar
to
blood
composition,
has
garnered
significant
attention
as
valuable
source
of
clinically
relevant
information.
Consequently,
ISF-based
wearable
biosensors
are
emerging
powerful
tools
for
non-invasive
minimally
invasive
disease
diagnosis,
personalized
medicine,
other
healthcare
biomedical
applications.
This
review
provides
comprehensive
overview
recent
advancements
biosensors,
with
particular
focus
on
ISF
sensors.
We
first
offer
insights
into
sampling
techniques
discuss
sensing
strategies
that
encompass
materials,
fabrication
methods,
mechanisms.
Then,
we
present
their
Finally,
address
the
challenges
faced
this
field
forward-looking
perspective
promising
future
directions.
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(3), P. 1149 - 1161
Published: March 13, 2024
Interstitial
fluid
(ISF)
has
attracted
extensive
attention
in
an
extremely
wide
range
of
areas
due
to
its
unique
advantages,
such
as
portability,
high
precision,
comfortable
operation,
and
superior
stability.
In
recent
years,
the
microneedle
(MN)
technique
been
considered
be
excellent
tool
for
extracting
ISF
because
it
is
painless
noninvasive.
Recent
reports
have
shown
that
MN
good
application
prospects
extraction.
this
review,
we
provide
comprehensive
in-depth
insight
into
integrated
devices
detection,
covering
basic
structure
well
fabrication
various
applications
Challenges
are
highlighted,
with
a
discussion
on
how
transition
MN-integrated
toward
personalized
healthcare
monitoring
systems.
Molecular Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Microneedles
(MNs)
are
emerging
as
versatile
tools
for
both
therapeutic
drug
delivery
and
diagnostic
monitoring.
Unlike
hypodermic
needles,
MNs
achieve
these
applications
with
minimal
or
no
pain
customizable
designs,
making
them
suitable
personalized
medicine.
Understanding
the
key
design
parameters
challenges
during
contact
biofluids
is
crucial
to
optimizing
their
use
across
applications.
This
review
summarizes
current
fabrication
techniques
considerations
tailored
meet
distinct
requirements
biosensing
We
further
underscore
state
of
theranostic
that
integrate
propose
future
directions
advancing
toward
clinical
use.
