Arrays of Triangular Au Nanoparticles with Self-Cleaning Capacity for High-Sensitivity Surface-Enhanced Raman Scattering DOI
Junnan Wang, Zeyu Wang, Jindou Shi

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(6), P. 5841 - 5852

Published: March 1, 2024

In the realm of surface-enhanced Raman scattering (SERS) research, precise detection and effective cleansing substances are critical. This study introduces a novel Au nanotriangle/Cs2AgBiBr6 (Au NT/CABB) SERS array, synthesized through meticulous two-step process, which demonstrates remarkable effectiveness. Using Rhodamine 6G (R6G) as probe molecule, this substrate accurately detects target molecules achieves an exceptional threshold 1 × 10–13 M. The integration CABB into endows it with photocatalytic properties, thereby accelerating degradation adsorbed signaling significantly enhancing reusability NT/CABB arrays. Furthermore, arrays exhibit outstanding performance methylene blue (MB) MB&R6G mixed solutions, distinguishing between two signal high fidelity. Additionally, enhancement mechanism array is analyzed by finite-difference time-domain (FDTD) simulation energy band structure. These findings highlight substrate's dual capability in leveraging both electromagnetic chemical mechanisms for superior performance, complemented integrated self-cleaning feature, making promising candidate environmental applications.

Language: Английский

Recent Trends in SERS-Based Plasmonic Sensors for Disease Diagnostics, Biomolecules Detection, and Machine Learning Techniques DOI Creative Commons
Reshma Beeram,

Kameswara Rao Vepa,

S. Venugopal Rao

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(3), P. 328 - 328

Published: Feb. 27, 2023

Surface-enhanced Raman spectroscopy/scattering (SERS) has evolved into a popular tool for applications in biology and medicine owing to its ease-of-use, non-destructive, label-free approach. Advances plasmonics instrumentation have enabled the realization of SERS’s full potential trace detection biomolecules, disease diagnostics, monitoring. We provide brief review on recent developments SERS technique biosensing applications, with particular focus machine learning techniques used same. Initially, article discusses need plasmonic sensors advantage over existing techniques. In later sections, are organized as SERS-based diagnosis focusing cancer identification respiratory diseases, including SARS-CoV-2 detection. then discuss progress sensing microorganisms, such bacteria, detecting biohazardous materials view homeland security. At end article, we (a) identification, (b) classification, (c) quantification applications. The covers work from 2010 onwards, language is simplified suit needs interdisciplinary audience.

Language: Английский

Citations

81
SERS-based microdevices for use as in vitro diagnostic biosensors DOI
Sungwoon Lee,

Hajun Dang,

Joung‐Il Moon

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(11), P. 5394 - 5427

Published: Jan. 1, 2024

This review explores various microdevices developed for applying SERS technology to in vitro diagnostics and delves into their clinical applications.

Language: Английский

Citations

54
Optical nanomaterial-based detection of biomarkers in liquid biopsy DOI Creative Commons
Young Jun Kim, Won‐Yeop Rho, Seung Min Park

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: March 14, 2024

Abstract Liquid biopsy, which is a minimally invasive procedure as an alternative to tissue has been introduced new diagnostic/prognostic measure. By screening disease-related markers from the blood or other biofluids, it promises early diagnosis, timely prognostication, and effective treatment of diseases. However, there will be long way until its realization due conceptual practical challenges. The biomarkers detected by liquid such circulating tumor cell (CTC) DNA (ctDNA), are extraordinarily rare often obscured abundance normal cellular components, necessitating ultra-sensitive accurate detection methods for advancement biopsy techniques. Optical biosensors based on nanomaterials open important opportunity in because their enhanced sensing performance with simple properties. In this review article, we summarized recent innovations optical demonstrate sensitive protein, peptide, ctDNA, miRNA, exosome, CTCs. Each study prepares tailored design enhance meet requirements each biomarker. unique characteristics metallic nanoparticles (NPs), quantum dots, upconversion NPs, silica polymeric carbon exploited mechanisms. These advances using give us overcome challenging issues provide resource understanding unknown well mechanism disease. Graphical abstract

Language: Английский

Citations

18
Recent advancements in the applications of separation and enrichment strategies towards SERS detection DOI

Dongjie Zhang,

Huandi Li,

Xiao Li

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: 184, P. 118136 - 118136

Published: Jan. 7, 2025

Language: Английский

Citations

4
Surface-enhanced Raman scattering for the detection of biomarkers of neurodegenerative diseases: A review DOI
Chentao Li,

Yinglin Wang,

Yafang Wu

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: 185, P. 118173 - 118173

Published: Feb. 3, 2025

Language: Английский

Citations

2
Current research status of tumor cell biomarker detection DOI Creative Commons

Liying Jiang,

Xinyi Lin, Fenghua Chen

et al.

Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)

Published: Oct. 5, 2023

Abstract With the annual increases in morbidity and mortality rates of tumors, use biomarkers for early diagnosis real-time monitoring tumor cells is great importance. Biomarkers used cell detection body fluids include circulating cells, nucleic acids, protein markers, extracellular vesicles. Among them, DNA, exosomes have high potential prediction, diagnosis, prognosis diseases due to large amount valuable information on characteristics evolution; addition, situ telomerase miRNA living has been topic extensive research understand development real time. Various techniques, such as enzyme-linked immunosorbent assays, immunoblotting, mass spectrometry, widely these markers. markers based electrochemical biosensors fluorescence signal analysis highly preferred because its sensitivity, rapid portable operation. Herein, we summarize recent progress using biosensors, outline current status discuss technical challenges their practical clinical application provide a reference new marker methods.

Language: Английский

Citations

24
Dual-Mode Separation and SERS Detection of Carbaryl with PA-6/AuNRs@ZIF-8 Films DOI

Yan Ding,

Cheng Liu,

Yang Shi

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(5), P. 1941 - 1947

Published: Jan. 27, 2024

Appropriate separation and enrichment steps can enhance the performance of SERS assays. For rapid, in-situ detection carbaryl, a novel PA-6/AuNRs@ZIF-8 film that be applied to dual-mode detection, has been developed. In film, PA-6 was used as TLC substrate for initial substance measured. ZIF-8 provides chemical enhancement in well secondary analytes. Utilizing this we have successfully implemented TLC-SERS rapid scheme, resulting limit carbaryl low 1 × 10–9 M lake water 15 min, which is significantly lower than existing standards. Additionally, manufacturing cost one kept within range $0.20–$0.40 economically, presenting substantial financial advantages. The method highly promising pesticide forensic testing.

Language: Английский

Citations

15
Advances of machine learning-assisted small extracellular vesicles detection strategy DOI
Qí Zhāng, Ting-Ju Ren, Ke Cao

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 251, P. 116076 - 116076

Published: Feb. 1, 2024

Language: Английский

Citations

15
Electrochemical Sensor for the Detection and Accurate Early Diagnosis of Ovarian Cancer DOI

Feng Ge,

Ding Wei, Cong Han

et al.

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(6), P. 2897 - 2906

Published: May 22, 2024

Ovarian cancer (OC) has the highest mortality rate among malignant tumors, primarily because it is difficult to diagnose early. Exosomes, a type of extracellular vesicle rich in parental information, have garnered significant attention field diagnosis and treatment. They play an important regulatory role occurrence, development, metastasis OC. Consequently, exosomes emerged as noninvasive biomarkers for early detection. Therefore, identifying cancer-derived may offer novel biomarker detection In this study, we developed metal–organic frameworks assembled "double hook"-type aptamer electrochemical sensor, which enables accurate Under optimal experimental conditions, impedance spectroscopy technology demonstrated good linear relationship within concentration range 31–3.1 × 106 particles per microliter, with limit low 12 microliter. The universal exosome platform constructed, can not only differentiate between high-grade serous ovarian (HGSOC) patients healthy individuals but also distinguish HGSOC nonhigh-grade OC (non-HGSOC). provides strategy holds great significance clinical differential diagnosis.

Language: Английский

Citations

11
Electrochemical aptamer-based biosensing of glycan-conjugated targets DOI Creative Commons

Junpeng Lv,

Jianwen Wan,

Di Wu

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 36 - 45

Published: Jan. 17, 2024

As the most complex post-translational modification, glycosylation involves covalent linking of glycan(s) to a biomolecule. The proteins, peptides, lipids, and nucleic acids results in formation diverse glycoconjugates, like glycoproteins, peptidoglycans, glycopeptides, glycolipids, lipopolysaccharides, glycoRNAs, glycoconjugates are also ubiquitous on surface extracellular vesicles (EVs), cells, bacteria, viruses. conjugated glycans integral cell recognition (e.g., adhesion homing), trafficking, immune recognition, hormone-receptor binding, protein folding stabilization, many other biological processes. Currently, glycan-conjugated objects have found widespread applications disease diagnosis exosomes, circulating tumor cells) therapy therapeutic monoclonal antibodies). Over past decades, variety methods been established for quantitative assay objects, light their significant diagnostic values, using antibodies, aptamers, or affinity peptides as ligands. Relative methods, aptamer-based electrochemical biosensors (i.e., aptasensors) attracted much attention recent years detection targets, by virtue intrinsic advantages such low cost, good portability, simple instrument, superior stability anti-interference capability, high sensitivity selectivity. This review summarizes biological, diagnostic, significance then presents progress aptasensing including lipopolysaccharides (LPSs), cells (CTCs), pathogenic microbes bacteria viruses). Moreover, challenges future prospects discussed.

Language: Английский

Citations

9