Global Assessment of Bisphenol A in the Environment

Dose-Response, Journal Year: 2015, Volume and Issue: 13(3)

Published: July 1, 2015

Because bisphenol A (BPA) is a high production volume chemical, we examined over 500 peer-reviewed studies to understand its global distribution in effluent discharges, surface waters, sewage sludge, biosolids, sediments, soils, air, wildlife, and humans. Bisphenol was largely reported from urban ecosystems Asia, Europe, North America; unfortunately, information lacking large geographic areas, megacities, developing countries. When sufficient data were available, probabilistic hazard assessments performed environmental quality concerns. Exceedances of Canadian Predicted No Effect Concentrations for aquatic life >50% effluents America but as 80% water reports Asia. Similarly, maximum concentrations BPA sediments Asia higher than Europe. mostly fish, ranged 0.2 13 000 ng/g. We observed 60% 40% exceedences median levels by the US Centers Disease Control Prevention's National Health Nutrition Examination Survey Europe respectively. These findings highlight utility coordinating sensing contaminants efforts through integration monitoring specimen banking identify regions implementation more robust assessment management programs.

Language: Английский

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Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2014, Volume and Issue: 369(1656), P. 20130580 - 20130580

Published: Oct. 14, 2014

The study of animal behaviour is important for both ecology and ecotoxicology, yet research in these two fields currently developing independently. Here, we synthesize the available knowledge on drug-induced behavioural alterations fish, discuss potential ecological consequences report results from an experiment which quantify uptake impact a psychiatric drug predatory fish (Perca fluviatilis) its invertebrate prey (Coenagrion hastulatum). We show that perch became more active while damselfly was unaffected, illustrating effects pharmaceuticals can differ between species. Furthermore, demonstrate consumption be exposure route as average 46% pharmaceutical ingested accumulated predator. This suggests investigations through bioconcentration, where trophic interactions subsequent bioaccumulation exposed individuals are ignored, underestimate exposure. Wildlife may therefore to higher levels behaviourally altering than predictions based commonly used assays concentrations found environmental monitoring programmes.

Language: Английский

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Method validation and reconnaissance of pharmaceuticals, personal care products, and alkylphenols in surface waters, sediments, and mussels in an urban estuary

Environment International, Journal Year: 2013, Volume and Issue: 54, P. 92 - 99

Published: Feb. 18, 2013

Language: Английский

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Human Pharmaceuticals in the Aquatic Environment: A Review of Recent Toxicological Studies and Considerations for Toxicity Testing

Reviews of Environmental Contamination and Toxicology, Journal Year: 2012, Volume and Issue: unknown, P. 1 - 99

Published: Jan. 1, 2012

Language: Английский

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Comparison of contaminants of emerging concern removal, discharge, and water quality hazards among centralized and on-site wastewater treatment system effluents receiving common wastewater influent

The Science of The Total Environment, Journal Year: 2013, Volume and Issue: 466-467, P. 976 - 984

Published: Aug. 28, 2013

Language: Английский

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The Read-Across Hypothesis and Environmental Risk Assessment of Pharmaceuticals

Environmental Science & Technology, Journal Year: 2013, Volume and Issue: 47(20), P. 11384 - 11395

Published: Sept. 5, 2013

Pharmaceuticals in the environment have received increased attention over past decade, as they are ubiquitous rivers and waterways. Concentrations sub-ng to low μg/L, well below acute toxic levels, but there uncertainties regarding effects of chronic exposures is a need prioritise which pharmaceuticals may be concern. The read-across hypothesis stipulates that drug will an effect non-target organisms only if molecular targets such receptors enzymes been conserved, resulting (specific) pharmacological plasma concentrations similar human therapeutic concentrations. If this holds true for different classes pharmaceuticals, it should possible predict potential environmental impact from information obtained during development process. This paper critically reviews evidence read-across, finds few studies include mode action based effects. Thus, despite large number apparently relevant papers general acceptance hypothesis, absence documented evidence. There large-scale generate robust data testing developing predictive models, feasible approach protecting environment.

Language: Английский

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Analysis of multi-class pharmaceuticals in fish tissues by ultra-high-performance liquid chromatography tandem mass spectrometry

Journal of Chromatography A, Journal Year: 2013, Volume and Issue: 1288, P. 63 - 72

Published: March 13, 2013

Language: Английский

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Uptake and Tissue Distribution of Pharmaceuticals and Personal Care Products in Wild Fish from Treated-Wastewater-Impacted Streams

Environmental Science & Technology, Journal Year: 2015, Volume and Issue: 49(19), P. 11649 - 11658

Published: Sept. 8, 2015

A fish plasma model (FPM) has been proposed as a screening technique to prioritize potential hazardous pharmaceuticals wild fish. However, this approach does not account for inter- or intraspecies variability of pharmacokinetic and pharmacodynamic parameters. The present study elucidated the uptake potency (from ambient water), tissue distribution, biological risk 20 pharmaceutical personal care product (PPCP) residues in cyprinoid inhabiting treated-wastewater-impacted streams. In order clarify uncertainty FPM PPCPs, we compared bioaccumulation factor field (BAFplasma = measured plasma/ambient water concentration ratio) with predicted bioconcentration (BCFplasma by use theoretical partition coefficients/ambient actual environment. As result, maximum BAFplasma inflammatory agents was up 17 times higher than BCFplasma values, leading possible underestimation toxicological on When tissue–blood coefficients (tissue/blood ratios) PPCPs were estimated, transportability into tissues, especially brain, found psychotropic agents, but brain/plasma ratios widely varied among individual (up 28-fold). study, provide valuable data set PPCP pharmacokinetics, our results emphasize importance determining concentrations target organs well blood assess

Language: Английский

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Determination of a broad spectrum of pharmaceuticals and endocrine disruptors in biofilm from a waste water treatment plant-impacted river

The Science of The Total Environment, Journal Year: 2015, Volume and Issue: 540, P. 241 - 249

Published: June 15, 2015

Wastewater treatment plants (WWTPs) are one of the main sources pharmaceuticals and endocrine disrupting compounds in freshwater ecosystems, several studies have reported bioaccumulation these different organisms those ecosystems. River biofilms exceptional indicators pollution, but very few focused on accumulation emerging contaminants. The objectives this study were first to develop an efficient analytical methodology for simultaneous analysis 44 13 biofilm, second, assess persistence, distribution, contaminants natural inhabiting a WWTP-impacted river. method is based pressurized liquid extraction, purification by solid-phase ultra performance chromatography coupled mass spectrometer (UPLC-MS/MS) tandem. Recoveries 31-137%, disruptors 32-93%. Method detection limits range 0.2-2.4 ng g(-1), pharmaceuticals, 0.07-6.7 g(-1). A total five seven detected field samples at concentrations up 100

Language: Английский

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Fish on Prozac (and Zoloft): Ten years later

Aquatic Toxicology, Journal Year: 2014, Volume and Issue: 151, P. 61 - 67

Published: Jan. 19, 2014

Language: Английский

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