Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)

Published: Nov. 5, 2023

Abstract Cancer immunotherapy has the potential to revolutionize treatment of malignant tumors, but its effectiveness is limited by low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute antitumor immunity, converting “cold” tumors “hot”. Particularly, biomaterials loading pyroptosis inducers targeting tumor microenvironment engineer pyroptosis, have achieved great progress in recent years. Herein, design strategy, mechanism pathway, role induce cancer are comprehensively reviewed. The present review focuses on application biomaterials‐induced immunotherapy, including nanogel, polymer prodrug, nanovesicle, mesoporous material. Additionally, synthesis a series stimuli‐responsive nanoplatforms, glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, enzyme‐mimicking catalytic performance, described. Meanwhile, it augments multiple processes uptake, antigen presentation, T‐cell activation, expansion. Finally, perspectives pyroptosis‐mediated inflammation break through vascular basement membrane barrier achieving efficient volcanic penetration discussed. Artificial intelligence, multi‐omics analysis, anthropogenic animal models organoids presented, aiming provide guidance assistance for constructing effective controllable pyroptosis‐engineered improving immunotherapy.

Language: Английский

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Surface Engineering on Bacteria for Tumor Immunotherapy: Strategies and Perspectives

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

Abstract Bacteria have garnered significant attention in tumor immunotherapy recently years, owing to their immune‐activating properties, ease of genetic manipulation, and colonization abilities. In order further enhance the safety, efficacy, clinical translation potential bacterial therapy, endow bacteria with additional functions, modifications or engineering surfaces emerged as a current research hotspot. This review systematically summarizes primary methods strategies for surface modification engineering, including chemical alteration, physical modification, bio‐modification. Subsequently, it is delve into roles these techniques enhancing immunotherapy, such improving immunotherapeutic efficacy reducing toxic side effects, elucidate underlying mechanisms. Finally, challenges faced this field are deeply explored, solutions future presented. work offers comprehensive overview advancements new generation implications bacterial‐based immunotherapy.

Language: Английский

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A NIR‐Light‐Activated and Lysosomal‐Targeted Pt(II) Metallacycle for Highly Potent Evoking of Immunogenic Cell Death that Potentiates Cancer Immunotherapy of Deep‐Seated Tumors

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(37)

Published: May 22, 2024

Though platinum (Pt)-based complexes have been recently exploited as immunogenic cell death (ICD) inducers for activating immunotherapy, the effective activation of sufficient immune responses with minimal side effects in deep-seated tumors remains a formidable challenge. Herein, we propose first example near-infrared (NIR) light-activated and lysosomal targeted Pt(II) metallacycle (1) supramolecular ICD inducer. 1 synergistically potentiates immunomodulatory response via multiple-regulated approaches, involving NIR light excitation, boosted reactive oxygen species (ROS) generation, good selectivity between normal tumor cells, enhanced penetration/retention capabilities. Specifically, has excellent depth-activated ROS production (~7 mm), accompanied by strong anti-diffusion anti-ROS quenching ability. In vitro experiments demonstrate that exhibits significant cellular uptake generation cells well respective multicellular spheroids. Based on these advantages, induces more efficient an ultralow dose (i.e., 5 μM) compared clinical inducer-oxaliplatin (300 μM). vivo, vaccination further serves potent inducer through eliciting CD8

Language: Английский

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Rhenium(I) coordinated carbon nitride as type II immunogenic cell death inducers for enhancing photoimmunotherapy against triple-negative breast cancer

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 485, P. 150154 - 150154

Published: March 2, 2024

Language: Английский

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Recent advancement in photosensitizers for photodynamic therapy

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 229, P. 112262 - 112262

Published: June 6, 2024

Language: Английский

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Engineered bacteria in tumor immunotherapy

Cancer Letters, Journal Year: 2024, Volume and Issue: 589, P. 216817 - 216817

Published: March 15, 2024

Language: Английский

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Microbially synthesized nanomaterials: Advances and applications in biomedicine

Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100019 - 100019

Published: Feb. 1, 2025

Language: Английский

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Targeting the Adenosine‐Mediated Metabolic Immune Checkpoint with Engineered Probiotic for Enhanced Chemo‐Immunotherapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Abstract Immunotherapy has revolutionized cancer treatment by leveraging the patient's immune system, yet its efficacy is often hampered immunosuppressive tumor microenvironment (TME). Adenosine, a key player in this milieu, suppresses cell activity via cAMP signaling. Here, an innovative strategy to remodel TME using genetically engineered strain of Escherichia coli Nissle 1917 that expresses adenosine deaminase on surface under hypoxic conditions presented. This probiotic targets tumors, converts inosine, and enhances anti‐tumor responses. In vivo, significantly improved infiltration demonstrated synergistic effects with low‐dose doxorubicin both subcutaneous orthotopic mouse colorectal model. Furthermore, modulated TME, promoting shift from M2‐like M1‐like macrophages increasing effector T populations. These findings highlight potential probiotics for metabolic modulation offering novel approach enhancing immunotherapy.

Language: Английский

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Iridium(III) Photosensitizers Induce Simultaneous Pyroptosis and Ferroptosis for Multi‐Network Synergistic Tumor Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(49)

Published: Aug. 24, 2024

Abstract The integration of pyroptosis and ferroptosis hybrid cell death induction to augment immune activation represents a promising avenue for anti‐tumor treatment, but there is lack research. Herein, we developed two iridium (III)‐triphenylamine photosensitizers, IrC IrF , with the capacity disrupt redox balance induce photo‐driven cascade damage DNA Kelch‐like ECH‐associated protein 1 (KEAP1). absent in melanoma 2 (AIM2)‐related cytoplasmic nucleic acid‐sensing pathway, triggered by damaged DNA, leads gasdermin D (GSDMD)‐mediated pyroptosis. Simultaneously, iron homeostasis, regulated KEAP1/nuclear factor erythroid 2‐related (NRF2)/heme oxygenase (HO‐1) serves as pivotal bridge, facilitating not only E (GSDME)‐mediated non‐canonical pyroptosis, also synergy glutathione peroxidase 4 (GPX4) depletion. collaborative action generates synergistic effect that elicits immunogenic death, stimulates robust response effectively inhibits tumor growth vivo. Our work introduces first metal‐based small molecule dual‐inducers potent cancer immunotherapy, highlights significance homeostasis vital hub connecting effects ferroptosis.

Language: Английский

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Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

Small Methods, Journal Year: 2024, Volume and Issue: 8(11)

Published: Sept. 25, 2024

Abstract Despite the advent of various medical interventions for cancer treatment, disease continues to pose a formidable global health challenge, necessitating development new therapeutic approaches more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light activate photosensitizer produce cytotoxic reactive oxygen species (ROS) eradicating cells, has emerged as promising approach due its high spatiotemporal precision and minimal invasiveness. However, widespread clinical use PDT faces several challenges, including inefficient production ROS in hypoxic tumor microenvironment, limited penetration depth biological tissues, inadequate accumulation photosensitizers at site. Over past decade, there been increasing interest utilization photofunctional transition metal complexes applications their intriguing photophysical photochemical properties. This review provides an overview current design strategies used innovative phototherapeutics, aiming address limitations associated with achieve The challenges future perspectives on translation are also discussed.

Language: Английский

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