Chemical Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Polyphenol-functionalized nanoarchitectures (cytoPNAs) provide a modular and cell independent strategy to create biohybrids for engineering, with improved production biomanufacturing enhanced efficacy cell-based therapies.
Language: Английский
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)
Published: Nov. 5, 2023
Abstract Cancer immunotherapy has the potential to revolutionize treatment of malignant tumors, but its effectiveness is limited by low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute antitumor immunity, converting “cold” tumors “hot”. Particularly, biomaterials loading pyroptosis inducers targeting tumor microenvironment engineer pyroptosis, have achieved great progress in recent years. Herein, design strategy, mechanism pathway, role induce cancer are comprehensively reviewed. The present review focuses on application biomaterials‐induced immunotherapy, including nanogel, polymer prodrug, nanovesicle, mesoporous material. Additionally, synthesis a series stimuli‐responsive nanoplatforms, glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, enzyme‐mimicking catalytic performance, described. Meanwhile, it augments multiple processes uptake, antigen presentation, T‐cell activation, expansion. Finally, perspectives pyroptosis‐mediated inflammation break through vascular basement membrane barrier achieving efficient volcanic penetration discussed. Artificial intelligence, multi‐omics analysis, anthropogenic animal models organoids presented, aiming provide guidance assistance for constructing effective controllable pyroptosis‐engineered improving immunotherapy.
Language: Английский
Citations
26
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: May 17, 2024
Abstract Bacteria have garnered significant attention in tumor immunotherapy recently years, owing to their immune‐activating properties, ease of genetic manipulation, and colonization abilities. In order further enhance the safety, efficacy, clinical translation potential bacterial therapy, endow bacteria with additional functions, modifications or engineering surfaces emerged as a current research hotspot. This review systematically summarizes primary methods strategies for surface modification engineering, including chemical alteration, physical modification, bio‐modification. Subsequently, it is delve into roles these techniques enhancing immunotherapy, such improving immunotherapeutic efficacy reducing toxic side effects, elucidate underlying mechanisms. Finally, challenges faced this field are deeply explored, solutions future presented. work offers comprehensive overview advancements new generation implications bacterial‐based immunotherapy.
Language: Английский
Citations
15
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(37)
Published: May 22, 2024
Though platinum (Pt)-based complexes have been recently exploited as immunogenic cell death (ICD) inducers for activating immunotherapy, the effective activation of sufficient immune responses with minimal side effects in deep-seated tumors remains a formidable challenge. Herein, we propose first example near-infrared (NIR) light-activated and lysosomal targeted Pt(II) metallacycle (1) supramolecular ICD inducer. 1 synergistically potentiates immunomodulatory response via multiple-regulated approaches, involving NIR light excitation, boosted reactive oxygen species (ROS) generation, good selectivity between normal tumor cells, enhanced penetration/retention capabilities. Specifically, has excellent depth-activated ROS production (~7 mm), accompanied by strong anti-diffusion anti-ROS quenching ability. In vitro experiments demonstrate that exhibits significant cellular uptake generation cells well respective multicellular spheroids. Based on these advantages, induces more efficient an ultralow dose (i.e., 5 μM) compared clinical inducer-oxaliplatin (300 μM). vivo, vaccination further serves potent inducer through eliciting CD8
Language: Английский
Citations
15
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 485, P. 150154 - 150154
Published: March 2, 2024
Language: Английский
Citations
13
Cancer Letters, Journal Year: 2024, Volume and Issue: 589, P. 216817 - 216817
Published: March 15, 2024
Language: Английский
Citations
12
Dyes and Pigments, Journal Year: 2024, Volume and Issue: 229, P. 112262 - 112262
Published: June 6, 2024
Language: Английский
Citations
12
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(49)
Published: Aug. 24, 2024
Abstract The integration of pyroptosis and ferroptosis hybrid cell death induction to augment immune activation represents a promising avenue for anti‐tumor treatment, but there is lack research. Herein, we developed two iridium (III)‐triphenylamine photosensitizers, IrC IrF , with the capacity disrupt redox balance induce photo‐driven cascade damage DNA Kelch‐like ECH‐associated protein 1 (KEAP1). absent in melanoma 2 (AIM2)‐related cytoplasmic nucleic acid‐sensing pathway, triggered by damaged DNA, leads gasdermin D (GSDMD)‐mediated pyroptosis. Simultaneously, iron homeostasis, regulated KEAP1/nuclear factor erythroid 2‐related (NRF2)/heme oxygenase (HO‐1) serves as pivotal bridge, facilitating not only E (GSDME)‐mediated non‐canonical pyroptosis, also synergy glutathione peroxidase 4 (GPX4) depletion. collaborative action generates synergistic effect that elicits immunogenic death, stimulates robust response effectively inhibits tumor growth vivo. Our work introduces first metal‐based small molecule dual‐inducers potent cancer immunotherapy, highlights significance homeostasis vital hub connecting effects ferroptosis.
Language: Английский
Citations
9
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2548 - 2558
Published: May 24, 2024
Chemotherapy faces critical challenges in clinical oncology treatment. One primary reason is the tumor hypoxia that obstructs penetration of chemotherapeutic drugs into solid tumors and diminishes drug concentration cells, leading to suboptimal treatment outcomes. Thereupon, we create a self-immolative phototherapeutic prodrug (DHQ-AZO-BIO) featured with targeting activation. First, heavy-atom-free photosensitizer based on intramolecular noncovalent interactions (NCIs), which specifically enriches produces photocytotoxic 1O2 eliminate normoxic cells surface layer by photodynamic therapy (PDT). Second, PDT process also increases hypoxic degree within tumor, thereby improving on-demand release action efficiency hypoxia-sensitive prodrug. This combined fashion synergizes hypoxia-activated chemotherapy overcome limitation augment therapeutic index for tumors, contributing development delivery systems (DDSs) precise phototherapy tumors.
Language: Английский
Citations
8
Small Methods, Journal Year: 2024, Volume and Issue: 8(11)
Published: Sept. 25, 2024
Abstract Despite the advent of various medical interventions for cancer treatment, disease continues to pose a formidable global health challenge, necessitating development new therapeutic approaches more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light activate photosensitizer produce cytotoxic reactive oxygen species (ROS) eradicating cells, has emerged as promising approach due its high spatiotemporal precision and minimal invasiveness. However, widespread clinical use PDT faces several challenges, including inefficient production ROS in hypoxic tumor microenvironment, limited penetration depth biological tissues, inadequate accumulation photosensitizers at site. Over past decade, there been increasing interest utilization photofunctional transition metal complexes applications their intriguing photophysical photochemical properties. This review provides an overview current design strategies used innovative phototherapeutics, aiming address limitations associated with achieve The challenges future perspectives on translation are also discussed.
Language: Английский
Citations
8
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 680, P. 9 - 24
Published: Oct. 30, 2024
Language: Английский
Citations
8