Inorganic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Developing
new
photocatalysts
for
the
selective
oxidation
of
thioethers
to
high-value-added
sulfoxides
under
low-oxygen
mild
conditions
is
a
promising
but
challenging
strategy.
Here,
polyoxometalate-based
metal–organic
framework
(POMOF),
CoBW12–TPT,
was
successfully
synthesized,
wherein
continuous
π···π
stacking
interactions
and
direct
coordination
bonds
not
only
strengthen
framework's
stability
also
accelerate
electron
transfer.
A
series
experiments
theoretical
studies,
including
control
experiments,
kinetic
electrochemical
spectroscopic
analyses,
paramagnetic
resonance,
revealed
synergistic
catalytic
effect
among
Co(II)
metal
centers,
BW12O405–,
photosensitizer
TPT.
CoBW12–TPT
applied
in
photocatalytic
sulfoxides.
Under
irradiation,
photoinduced
transfer
POMOF
leads
generation
superoxide
radicals
from
O2,
which
controls
sulfoxide
compounds
desulfurization
reaction
shows
good
activity.
In
particular,
it
can
be
construction
some
drug
molecules
such
as
Modafinil
Albendazole
Oxide.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 2, 2024
Abstract
Practical
photodynamic
therapy
calls
for
high-performance,
less
O
2
-dependent,
long-wavelength-light-activated
photosensitizers
to
suit
the
hypoxic
tumor
microenvironment.
Iridium-based
exhibit
excellent
photocatalytic
performance,
but
in
vivo
applications
are
hindered
by
conventional
-dependent
Type-II
photochemistry
and
poor
absorption.
Here
we
show
a
general
metallopolymerization
strategy
engineering
iridium
complexes
exhibiting
Type-I
enhancing
absorption
intensity
blue
near-infrared
region.
Reactive
oxygen
species
generation
of
metallopolymer
Ir-P1
,
where
atom
is
covalently
coupled
polymer
backbone,
over
80
times
higher
than
that
its
mother
without
under
680
nm
irradiation.
This
also
works
effectively
when
directly
included
(
Ir-P2
)
backbones,
wide
generality.
The
nanoparticles
efficient
•−
conjugated
with
integrin
αvβ3
binding
cRGD
achieve
targeted
therapy.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(5), P. 1870 - 1878
Published: Jan. 1, 2024
We
present
an
efficient
method
for
the
transformation
of
type
II
photosensitizers
(
1
O
2
)
into
I
(O
˙−
through
implementation
artificial
light-harvesting
system
involving
a
two-step
sequential
energy
transfer
process.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(15)
Published: Feb. 16, 2024
Developing
Type-I
photosensitizers
provides
an
attractive
approach
to
solve
the
dilemma
of
inadequate
efficacy
photodynamic
therapy
(PDT)
caused
by
inherent
oxygen
consumption
traditional
Type-II
PDT
and
anoxic
tumor
microenvironment.
The
challenge
for
exploration
PSs
is
facilitate
electron
transfer
ability
photosensitization
molecules
transforming
or
H
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(20), P. 13019 - 13034
Published: May 9, 2024
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
possess
different
merits
in
cancer
phototherapy,
but
the
tumor
microenvironment
becomes
unfavorable
during
phototheranostic
progress.
Herein,
we
report
a
self-adaptive
cyanine
derivative
Cy5-TPA
with
PDT-dominated
state
to
PTT-dominated
autoswitch
feature
for
enhanced
photoimmunotherapy.
The
incorporation
of
rotatable
triphenylamine
(TPA)
moiety
renders
temperature
or
intramolecular-motion
regulated
photoactivities,
which
shows
preferable
reactive
oxygen
species
(ROS)
generation
at
lower
while
stronger
conversion
higher
ones.
Such
promising
permits
situ
switch
from
along
intratumoral
increase
laser
irradiation,
also
works
line
concurrently
reduced
level,
exhibiting
phototherapeutic
behavior
maximize
antitumor
outcome.
Most
importantly,
facilitates
sequential
release
damage-associated
molecular
patterns
immunogenic
cell
death
(ICD).
Hence,
demonstrates
excellent
photoimmunotherapy
performance
ICD
induction,
dendritic
maturation,
T
activation
eradication
metastasis
inhibition.
Aggregate,
Journal Year:
2024,
Volume and Issue:
5(3)
Published: Feb. 1, 2024
Abstract
Phototherapeutic
nanoplatforms
that
combine
photodynamic
therapy
(PDT)
and
photothermal
(PTT)
with
the
guidance
of
photoacoustic
(PA)
imaging
are
an
effective
strategy
for
treatment
tumors,
but
establishing
a
universal
method
this
has
been
challenging.
In
study,
we
present
supramolecular
assembly
based
on
Förster
resonance
energy
transfer
to
construct
nanostructured
phototherapeutic
agent
(PcDA)
via
anion
cation
interaction
between
two
water‐soluble
phthalocyanine
ramifications,
PcD
PcA.
This
approach
promotes
absorption
energy,
thus
enhancing
generation
reactive
oxygen
species
(ROS)
heat
by
PcDA,
improving
its
therapeutic
efficacy,
overcoming
low
photon
utilization
efficiency
conventional
PSs.
Notably,
after
intravenous
injection
neoplastic
sites
could
be
clearly
visualized
using
PA
imaging,
signal‐to‐liver
ratio
as
high
11.9.
Due
these
unique
features,
PcDA
exhibits
excellent
antitumor
efficacy
in
preclinical
model
at
dose
light
irradiation.
study
offers
general
development
efficient
agents
simultaneous
effect
PDT
PTT
against
tumors
assistance
imaging.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(14)
Published: Feb. 14, 2024
Immunotherapy
faces
insufficient
immune
activation
and
limited
effectiveness.
Herein,
we
report
a
smart
DNA
hydrogel
that
enables
the
release
of
multivalent
functional
units
at
tumor
site
to
enhance
efficacy
immunotherapy.
The
was
assembled
from
two
types
ultra-long
chains
synthesized
via
rolling
circle
amplification.
One
chain
contained
adjuvant
CpG
oligonucleotides
polyaptamers
for
loading
natural
killer
cell-derived
exosomes;
other
G-quadruplex
photodynamic
agents.
formed
through
base-pairing.
HhaI
restriction
endonuclease
sites
were
designed
between
units.
Upon
stimuli
in
sites,
effectively
cleaved
by
released
disassembled
into
Natural
exosomes
played
an
anti-tumor
role,
oligonucleotide
activated
antigen-presenting
cells
Besides
tumor-killing
effect
therapy,
generated
cellular
debris
acted
as
antigen
further
immunotherapeutic
effect.
In
mouse
melanoma
orthotopic
model,
localized
therapeutic
agent,
achieved
remarkable
suppression
rate
91.2
%.
exhibited
enhanced
synergistic
immunotherapy
expanding
application
materials
biomedicine.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(14)
Published: Feb. 2, 2024
Abstract
The
development
of
novel
materials
for
highly
efficient
and
selective
photocatalysis
is
crucial
their
practical
applications.
Herein,
we
employ
the
host‐guest
chemistry
porphyrin‐based
metallacages
to
regulate
generation
reactive
oxygen
species
further
use
them
photocatalytic
oxidation
benzyl
alcohols.
Upon
irradiation,
sole
metallacage
(
6
)
can
generate
singlet
1
O
2
effectively
via
excited
energy
transfer,
while
its
complex
with
C
70
⊃C
opens
a
pathway
electron
transfer
promote
formation
superoxide
anion
(O
⋅
−
),
producing
both
.
addition
4,4′‐bipyridine
(BPY)
forms
more
stable
⊃BPY)
coordination
Zn‐porphyrin
faces
BPY,
which
drives
fullerenes
out
cavities
restores
ability
generation.
Therefore,
alcohols
are
oxidized
into
aldehydes
upon
irradiation
in
presence
or
⊃BPY,
they
benzoic
acids
when
employed
as
photosensitizing
agent.
This
study
demonstrates
strategy
that
utilizes
photooxidation
reactions,
could
utilization
related
complexes
