Molecular Engineering of a Tumor‐Targeting Thione‐Derived Diketopyrrolopyrrole Photosensitizer to Attain NIR Excitation Over 850 nm for Efficient Dual Phototherapy DOI Creative Commons
Gang Xu,

Yunxia Song,

Haifeng Jin

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Photosensitizers with near‐infrared (NIR) excitation, especially above 800 nm which is highly desired for phototherapy, remain rare due to the fast nonradiative relaxation process induced by exciton‐vibration coupling. Here, a diketopyrrolopyrrole‐derived photosensitizer (DTPA‐S) developed via thionation of carbonyl groups within diketopyrrolopyrrole skeleton, results in large bathochromic shift 81 nm, endowing strong NIR absorption at 712 nm. DTPA‐S then introduced functional biomolecule (N 3 ‐PEG 2000 ‐RGD) click reaction construction integrin αvβ3 receptor‐targeted nano‐micelles (NanoDTPA‐S/RGD), endows further superlarge redshift 138 thus extending maxima ≈850 Remarkably, thiocarbonyl substitution increases nonbonding characters frontier molecular orbitals, can effectively suppress vibrational reducing reorganization energy, enabling efficient reactive oxygen species (ROS) generation under 880 excitation. Screened vitro and vivo assays, NanoDTPA‐S/RGD high water solubility, excellent tumor‐targeting ability, photodynamic/photothermal therapy synergistic effect exhibits satisfactory phototherapeutic performance. Overall, this study demonstrates new design NIR‐triggered facile installation biomolecules potential clinical applications.

Language: Английский

Supramolecular systems for bioapplications: recent research progress in China DOI
Yue‐Yang Liu, Xiao-Yong Yu, Yu‐Chen Pan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 1397 - 1441

Published: March 22, 2024

Language: Английский

Citations

28
“Three birds with one stone” nanoplatform: Efficient near‐infrared‐triggered type‑I AIE photosensitizer for mitochondria‐targeted photodynamic therapy against hypoxic tumors DOI Creative Commons
Sheng-Nan Liu, Yutao Pei, Yan Sun

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: March 24, 2024

Abstract Currently three major problems seriously limit the practical application of cancer photodynamic therapy (PDT): (i) hypoxic tumor microenvironment (TME); (ii) low generation efficiency toxic reactive oxygen species (ROS) in aggregates and (iii) shallow tissue penetration depth excitation light. Very limited approaches are available for addressing all above with a single design. Herein, rational “three birds one stone” molecular nanoengineering strategy is demonstrated: nanoplatform U‐Ir@PAA‐ABS based on covalent combination lanthanide‐doped upconversion nanoparticles (UCNPs) an AIE‐active dinuclear Ir(III) complex provides concentration‐dependent type‐I photochemical process upon 980 nm irradiation by Föster resonance energy transfer (FRET). targets mitochondria has excellent phototoxicity even severe hypoxia environments irradiation, inducing dual‐mode cell death mechanism apoptosis ferroptosis. Taken together, vitro vivo results demonstrate successful improving efficacy PDT against tumors.

Language: Английский

Citations

25
The Midas Touch by Iridium: A Second Near-Infrared Aggregation-Induced Emission-Active Metallo-Agent for Exceptional Phototheranostics of Breast Cancer DOI
Caifa You,

Leyuan Tian,

Jun Zhu

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(2), P. 2010 - 2020

Published: Jan. 7, 2025

Developing small organic molecular phototheranostic agents with second near-infrared (NIR-II) aggregation-induced emission (AIE) is paramount for the phototriggered diagnostic imaging and synchronous in situ therapy of cancer via an excellent balance excited states energy dissipations. In this study, a multifunctional iridium(III) complex exploited by coordination AIE-active N^N ancillary ligand trivalent iridium ion. The resultant DPTPzIr significantly outperforms its parent terms absorption/emission wavelengths, reactive oxygen species (ROS) production, photothermal conversion, which simultaneously endow nanoparticles matched absorption peak to commercial 808 nm laser, longest NIR-II (above 1100 nm) among those previously reported AIE complexes, potentiated type-I ROS generation, as high 60.5% conversion efficiency. Consequently, perform well multimodal image-guided photodynamic therapy-photothermal breast tumor-bearing mice, enabling precise tumor diagnosis complete ablation biocompatibility. Our present work provides simple, feasible, effective paradigm development advanced agents.

Language: Английский

Citations

3
Excited State Structure and Decay Rates for Aggregates DOI Creative Commons
Zhigang Shuai, Qi Sun, Jiajun Ren

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

ABSTRACT Electronic excited state in molecular aggregate or exciton states continue to attract great attention due the increasing demands for applications of optoelectronics and sensing technology. The working principle behind application is closely related structure dynamic processes aggregate. In our previous review article (Aggregate 2021; 2: e91), we focused more on mechanism aggregation‐induced emission process. Here, are going summarize recent progress theoretical investigations effects excitonic coupling ( J ) intermolecular charge transfer (CT) processes. These general missing quantum chemistry studies. We will first present a novel definition coherence length which can bijective relation with radiative decay rate obviously have clarified confusion appeared literature. Then, look at CT effect starting from simple three‐state model coupled chemical calculation dimer focus intensity borrowing, turn H‐aggregate into emissive when electron hole integrals possessing same sign being large enough. able propose descriptor design materials possibly both high photoluminescence yield carrier mobility. Finally, introduce work modified energy gap law non‐radiative aggregates. found there exist optimal minimize loss.

Language: Английский

Citations

2
Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics DOI

Yifan Di,

Ruizhu Deng,

Zhu Liu

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122391 - 122391

Published: Nov. 15, 2023

Language: Английский

Citations

38
Anticancer profile of coumarin 6-based Ir(iii) photocatalysts under normoxia and hypoxia by ROS generation and NADH oxidation DOI
Ashish Kumar Yadav, Aarti Upadhyay, Arpan Bera

et al.

Inorganic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(17), P. 5435 - 5448

Published: Jan. 1, 2024

Coumarin 6 appended Ir( iii ) photocatalysts exhibited light activated anticancer effects against cancer cells via mitochondrial depolarization driven apoptosis by inducing type-I (NADH oxidation) and type-II (ROS generation) mechanisms.

Language: Английский

Citations

11
Intramolecular Repulsive Interactions Enable High Efficiency of NIR-II Aggregation-Induced Emission Luminogens for High-Contrast Glioblastoma Imaging DOI

Fulong Ma,

Zhiyuan Gao, Qian Jia

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Strategies to acquire high-efficiency luminogens that emit in the second near-infrared (NIR-II, 1000-1700 nm) range are still rare due impediment of energy gap law. Herein, a feasible strategy is pioneered by installing large-volume encumbrances confined space intensify repulsive interactions arising from overlapping electron densities. The experimental results, including smaller coordinate displacement, reduced reorganization energy, and suppressed internal conversion, demonstrate assist inhibition radiationless deactivation. Meanwhile, configuration hybridization form donor units transformed along with interactions, bringing about improved oscillator strength. A 3.8-fold higher luminescence efficiency realized via synergistic effect. Furthermore, endow NIR-II fluorophores highly twisted conformation, superior AIE activity, cascaded improvement fluorescence emission isolated molecules aggregates. By utilizing brain-targeting peptide functionalize nanoparticles, accurate detection high-contrast imaging orthotopic glioblastoma realized. This work not only explores fundamental principle handle intractable law but also provides potential applications bioimaging detection.

Language: Английский

Citations

1
Chemiluminescent transition metal complexes: Mechanisms and applications DOI
Jinghui Zhu,

Mingrui Gu,

Yahui Chen

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216495 - 216495

Published: Feb. 5, 2025

Language: Английский

Citations

1
Long-wavelength triggered iridium(iii) complex nanoparticles for photodynamic therapy against hypoxic cancer DOI Creative Commons
Sheng-Nan Liu, Ziwei Wang,

Zihan Wu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(73), P. 9938 - 9941

Published: Jan. 1, 2024

Nanoparticles incorporating an Ir( iii ) complex are photosensitisers that generate types I and II reactive oxygen species upon 655 nm laser irradiation achieve photodynamic therapy in hypoxic cancer cells by targeting mitochondria.

Language: Английский

Citations

6
Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics DOI Creative Commons
Lawrence Cho‐Cheung Lee, Kenneth Kam‐Wing Lo

Small Methods, Journal Year: 2024, Volume and Issue: 8(11)

Published: Sept. 25, 2024

Abstract Despite the advent of various medical interventions for cancer treatment, disease continues to pose a formidable global health challenge, necessitating development new therapeutic approaches more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light activate photosensitizer produce cytotoxic reactive oxygen species (ROS) eradicating cells, has emerged as promising approach due its high spatiotemporal precision and minimal invasiveness. However, widespread clinical use PDT faces several challenges, including inefficient production ROS in hypoxic tumor microenvironment, limited penetration depth biological tissues, inadequate accumulation photosensitizers at site. Over past decade, there been increasing interest utilization photofunctional transition metal complexes applications their intriguing photophysical photochemical properties. This review provides an overview current design strategies used innovative phototherapeutics, aiming address limitations associated with achieve The challenges future perspectives on translation are also discussed.

Language: Английский

Citations

6