Improving MOF stability: approaches and applications

Chemical Science, Journal Year: 2019, Volume and Issue: 10(44), P. 10209 - 10230

Published: Jan. 1, 2019

This review summarizes recent advances in the design and synthesis of stable MOFs highlights relationships between stability functional applications.

Language: Английский

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Metal–Organic Frameworks for Biomedical Applications

Small, Journal Year: 2020, Volume and Issue: 16(10)

Published: Feb. 6, 2020

Metal-organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes functional organic ligands through bonds, have attracted extensive research interest during the past decades. Due to unique features diverse compositions, facile synthesis, easy surface functionalization, high areas, adjustable porosity, tunable biocompatibility, MOFs been widely used in hydrogen/methane storage, catalysis, biological imaging sensing, drug delivery, desalination, gas separation, magnetic electronic devices, nonlinear optics, water vapor capture, etc. Notably, with rapid development synthetic methods functionalization strategies, smart MOF-based nanocomposites advanced bio-related properties designed fabricated meet growing demands MOF materials for biomedical applications. This work outlines synthesis recent advances fields, including cargo (drugs, nucleic acids, proteins, dyes) delivery cancer therapy, bioimaging, antimicrobial, biosensing, biocatalysis. The prospects challenges field also discussed.

Language: Английский

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Metal–Organic Frameworks for Drug Delivery: A Design Perspective

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(6), P. 7004 - 7020

Published: Feb. 7, 2021

The use of metal-organic frameworks (MOFs) in biomedical applications has greatly expanded over the past decade due to precision tunability, high surface areas, and loading capacities MOFs. Specifically, MOFs are being explored for a wide variety drug delivery applications. Initially, were used small-molecule pharmaceuticals; however, more recent work focused on macromolecular cargos, such as proteins nucleic acids. Here, we review historical application delivery, with specific focus available options designing These include choices MOF structure, synthetic method, loading. Further considerations tuning, modifications, biocompatibility, cellular targeting, uptake. Altogether, this Review aims guide design novel

Language: Английский

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Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications

Nano-Micro Letters, Journal Year: 2020, Volume and Issue: 12(1)

Published: May 2, 2020

Abstract Investigation of metal–organic frameworks (MOFs) for biomedical applications has attracted much attention in recent years. MOFs are regarded as a promising class nanocarriers drug delivery owing to well-defined structure, ultrahigh surface area and porosity, tunable pore size, easy chemical functionalization. In this review, the unique properties their advantages were discussed first section. Then, state-of-the-art strategies functionalize with therapeutic agents summarized, including adsorption, encapsulation, covalent binding, functional molecules building blocks. third section, most biological intracellular drugs, proteins, nucleic acids, especially aptamers, presented. Finally, challenges prospects comprehensively provide context future development efficient systems.

Language: Английский

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Metal–Organic Framework-Based Enzyme Biocomposites

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(3), P. 1077 - 1129

Published: Jan. 13, 2021

Because of their efficiency, selectivity, and environmental sustainability, there are significant opportunities for enzymes in chemical synthesis biotechnology. However, as the three-dimensional active structure is predominantly maintained by weaker noncovalent interactions, thermal, pH, stressors can modify or eliminate activity. Metal–organic frameworks (MOFs), which extended porous network materials assembled a bottom-up building block approach from metal-based nodes organic linkers, be used to afford protection enzymes. The self-assembled structures MOFs encase an enzyme process called encapsulation when MOF synthesized presence biomolecule. Alternatively, infiltrated into mesoporous surface bound via covalent processes. Integration this way affords allows maintain activity challenge conditions (e.g., denaturing agents, elevated temperature, non-native solvents). In addition forming simple enzyme/MOF biocomposites, other introduced composites improve recovery facilitate advanced applications sensing fuel cell technology. This review canvasses encapsulation, pore infiltration, adsorption summarizes strategies form multicomponent composites. Also, given that biocomposites straddle chemistry enzymology, provides assessment characterization methodologies MOF-immobilized identifies some key parameters development field.

Language: Английский

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A historical overview of the activation and porosity of metal–organic frameworks

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(20), P. 7406 - 7427

Published: Jan. 1, 2020

Since the first reports of metal-organic frameworks (MOFs), this unique class crystalline, porous materials has garnered increasing attention in a wide variety applications such as gas storage and separation, catalysis, enzyme immobilization, drug delivery, water capture, sensing. A fundamental feature MOFs is their porosity which provides space on micro- meso-scale for confining exposing functionalities. Therefore, designing with high developing suitable activation methods preserving accessing pore have been common theme MOF research. Reticular chemistry allows facile design from highly tunable metal nodes organic linkers order to realize different structures, topologies, With hope shedding light future research endeavors porosity, it worthwhile examine development MOFs, an emphasis how properly access space. In review, we will provide overview historic evolution followed by synopsis strategies preserve permanent MOFs.

Language: Английский

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Destruction of Metal–Organic Frameworks: Positive and Negative Aspects of Stability and Lability

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(23), P. 13087 - 13133

Published: Oct. 13, 2020

Metal-organic frameworks (MOFs), constructed from organic linkers and inorganic building blocks, are well-known for their high crystallinity, surface areas, component tunability. The stability of MOFs is a key prerequisite potential practical applications in areas including storage, separation, catalysis, biomedicine since it essential to guarantee the framework integrity during utilization. However, prone destruction under external stimuli, considerably hampering commercialization. In this Review, we provide an overview situations where undergo due stimuli such as chemical, thermal, photolytic, radiolytic, electronic, mechanical factors offer guidelines avoid unwanted degradation happened framework. Furthermore, discuss possible mechanisms varying derived products. particular, highlight cases that utilize MOF instability fabricate materials hierarchically porous MOFs, monolayer nanosheets, amorphous liquids glasses, polymers, metal nanoparticles, carbide carbon materials. Finally, perspective on utilization develop advanced with superior hierarchy various applications.

Language: Английский

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Reticular chemistry in the rational synthesis of functional zirconium cluster-based MOFs

Coordination Chemistry Reviews, Journal Year: 2019, Volume and Issue: 386, P. 32 - 49

Published: Feb. 10, 2019

Language: Английский

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Metal-organic frameworks for advanced drug delivery

Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(8), P. 2362 - 2395

Published: March 14, 2021

Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size shape, easy surface functionalization make this large family more popular for drug delivery. There is a growing interest over the last decades in design engineered MOFs with controlled sizes variety biomedical applications. This article presents an overall review perspectives MOFs-based delivery systems (DDSs), starting classification adapted DDSs based on types constituting metals ligands. Then, synthesis characterization developed, followed by loading strategies, applications, biopharmaceutics quality control. Importantly, representative applications detailed from point view pharmaceutics, diseases therapy advanced DDSs. In particular, control summarized critical issues to be addressed. Finally, challenges development discussed, such as biostability, biosafety, nomenclature.

Language: Английский

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Enhanced Drug Delivery by Dissolution of Amorphous Drug Encapsulated in a Water Unstable Metal–Organic Framework (MOF)

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(47), P. 16790 - 16794

Published: Sept. 24, 2019

Abstract Encapsulating a drug molecule into water‐reactive metal–organic framework (MOF) leads to amorphous confined within the nanoscale pores. Rapid release of occurs upon hydrolytic decomposition MOF in dissolution media. Application improve and solubility for hydrophobic small molecules curcumin, sulindac, triamterene is demonstrated. The drug@MOF composites exhibit significantly enhanced achieves high supersaturation simulated gastric and/or phosphate buffer saline This combination strategy where inhibits crystallization phase then releases irreversible structural collapse represents novel generalizable approach delivery poorly soluble compounds while overcoming traditional weakness delivery: physical instability form.

Language: Английский

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