Copper(I) Phosphide Nanocrystals for In Situ Self‐Generation Magnetic Resonance Imaging‐Guided Photothermal‐Enhanced Chemodynamic Synergetic Therapy Resisting Deep‐Seated Tumor DOI
Yang Liu, Junduo Wu, Yinhua Jin

et al.

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 29(50)

Published: Oct. 7, 2019

Abstract Fe‐based Fenton agents can generate highly reactive and toxic hydroxyl radicals (·OH) in the tumor microenvironment (TME) for chemodynamic therapy (CDT) with high specificity. However, strict condition (lower pH environment: 3–4) of efficient reaction limits its practical application clinic. Development new CDT more suitable TME is significant challenging. A Cu(I)‐based agent, copper(I) phosphide nanocrystals (CP NCs), which adaptable to value than agents, thereby producing ·OH trigger apoptosis cancer cells, prepared. Moreover, excess glutathione (GSH) reduce Cu(II) produced by a Fenton‐like Cu(I), further increasing generation rate relieving antioxidant ability. Furthermore, owing their strong absorption NIR II region, CP NCs exhibit an excellent photothermal conversion effect, improve reaction. What more, act as situ self‐generation magnetic resonance imaging (MRI) paramagnetic response H 2 O TME. These properties may open up exploration copper‐based materials clinical imaging‐guided synergetic treatment.

Language: Английский

Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions DOI
Yang Zhu, Wenyu Wang, Junjie Cheng

et al.

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(17), P. 9480 - 9488

Published: Feb. 6, 2021

Abstract The single‐atom enzyme (SAE) is a novel type of nanozyme that exhibits extraordinary catalytic activity. Here, we constructed PEGylated manganese‐based SAE (Mn/PSAE) by coordination manganese to nitrogen atoms in hollow zeolitic imidazolate frameworks. Mn/PSAE catalyzes the conversion cellular H 2 O . OH through Fenton‐like reaction; it also promotes decomposition and continuously cytotoxic − via oxidase‐like activity more pronounced weak acidic tumor environment; therefore, these cascade reactions enable sufficient generation reactive oxygen species (ROS) effectively kill cells. prominent photothermal property amorphous carbon can be utilized for therapy. Hence, significant therapeutic efficacy microenvironment stimulated multiple ROS

Language: Английский

Citations

381
2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases DOI Creative Commons
Wei Feng, Xiuguo Han, Hui Hu

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 13, 2021

Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved pathogenesis progression various human diseases. Here, we reported a two-dimensional (2D) vanadium carbide (V2C) MXene nanoenzyme (MXenzyme) that can mimic up to six naturally-occurring enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione (GPx), thiol (TPx) haloperoxidase (HPO). Based on these enzyme-mimicking properties, constructed 2D V2C MXenzyme not only possesses high biocompatibility but also exhibits robust vitro cytoprotection against oxidative stress. Importantly, rebuilds redox homeostasis without perturbing endogenous antioxidant status relieves ROS-induced damage with benign vivo therapeutic effects, as demonstrated both inflammation neurodegeneration animal models. These findings open an avenue enable use remedial nanoplatform treat ROS-mediated inflammatory neurodegenerative

Language: Английский

Citations

379
Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy DOI

Yaofeng Zhou,

Siyu Fan, Lili Feng

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Language: Английский

Citations

341
Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy DOI
Shulan Li, Peng Jiang, Feng‐Lei Jiang

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(22)

Published: March 8, 2021

Abstract Triggered by the endogenous chemical energy in tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic modality has received increasing attention recent years. The agents can convert internal hydrogen peroxide (H 2 O ) into lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other modalities, CDT possesses many notable advantages, such tumor‐specific, highly selective, fewer systemic side effects, and no need external stimulation. Nevertheless, mild acid pH, low H content, overexpressed reducing substance TME severely suppressed efficiency. With rapid development of nanotechnology, some kinds nanomaterials have been utilized improved In particular, excellent photo‐, ultrasound‐, magnetic‐, stimuli‐response properties make it possible combination cancer shown superior anti‐cancer activity than monotherapies. Therefore, is necessary to summarize application nanomaterial‐based therapy. this review, various nanomaterials‐based nanoplatforms its combinational therapies are summarized discussed, aiming provide inspiration design better‐quality promote lay foundation future conversion clinical applications.

Language: Английский

Citations

336
Single‐Atom Catalysts in Catalytic Biomedicine DOI
Huijing Xiang, Wei Feng, Yu Chen

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(8)

Published: Jan. 13, 2020

The intrinsic deficiencies of nanoparticle-initiated catalysis for biomedical applications promote the fast development alternative versatile theranostic modalities. catalytic performance and selectivity are critical issues that challenging to be augmented optimized in biological conditions. Single-atom catalysts (SACs) featuring atomically dispersed single metal atoms have emerged as one most explored biomedicine recently due their preeminent activity superior distinct from nanosized counterparts. Herein, an overview pivotal significance SACs some underlying need addressed is provided, with a specific focus on applications. Their fabrication strategies, surface engineering, structural characterizations discussed briefly. In particular, triggering representative reactions providing fundamentals use discussed. A sequence paradigms summarized successful construction varied (e.g., cancer treatment, wound disinfection, biosensing, oxidative-stress cytoprotection) emphasis uncovering mechanisms understanding structure–performance relationships. Finally, opportunities challenges faced future SACs-triggered outlooked.

Language: Английский

Citations

315
Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics DOI
Fei Gong, Nailin Yang, Xianwen Wang

et al.

Nano Today, Journal Year: 2020, Volume and Issue: 32, P. 100851 - 100851

Published: Feb. 21, 2020

Language: Английский

Citations

315
Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy DOI Creative Commons
Xianwen Wang, Qianqian Shi, Zhengbao Zha

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(12), P. 4389 - 4401

Published: April 30, 2021

Nanozymes have become a new generation of antibiotics with exciting broad-spectrum antibacterial properties and negligible biological toxicity. However, their inherent low catalytic activity limits properties. Herein, Cu single-atom sites/N doped porous carbon (Cu SASs/NPC) is successfully constructed for photothermal-catalytic treatment by pyrolysis-etching-adsorption-pyrolysis (PEAP) strategy. SASs/NPC stronger peroxidase-like activity, glutathione (GSH)-depleting function, photothermal property compared non-Cu-doped NPC, indicating that doping significantly improves the performance nanozymes. can effectively induce in presence H

Language: Английский

Citations

294
MnOx Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect DOI
Binbin Ding, Pan Zheng, Fan Jiang

et al.

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(38), P. 16381 - 16384

Published: June 2, 2020

Abstract Despite the widespread applications of manganese oxide nanomaterials (MONs) in biomedicine, intrinsic immunogenicity MONs is still unclear. MnO x nanospikes (NSs) as tumor microenvironment (TME)‐responsive nanoadjuvants and immunogenic cell death (ICD) drugs are proposed for cancer nanovaccine‐based immunotherapy. NSs with large mesoporous structures show ultrahigh loading efficiencies ovalbumin fragment. The combination ICD via chemodynamic therapy ferroptosis inductions, well antigen stimulations, presents a better synergistic immunopotentiation action. Furthermore, obtained nanovaccines achieve TME‐responsive magnetic resonance/photoacoustic dual‐mode imaging contrasts, while effectively inhibiting primary/distal growth metastasis.

Language: Английский

Citations

293
Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release DOI
Sheng Wang, Guocan Yu,

Zhantong Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(41), P. 14758 - 14763

Published: Aug. 20, 2019

Reactive oxygen species (ROS) can be used not only as a therapeutic agent for chemodynamic therapy (CDT), but also stimulus to activate release of antitumor drugs, achieving enhanced efficacy through the combination CDT and chemotherapy. Here we report pH/ROS dual-responsive nanomedicine consisting β-lapachone (Lap), pH-responsive polymer, ROS-responsive polyprodrug. In intracellular acidic environment, realize pH-triggered disassembly. The released Lap efficiently generate hydrogen peroxide, which will further converted into highly toxic hydroxyl radicals via Fenton reaction. Subsequently, ROS-induced cleavage thioketal linker, doxorubicin is from vivo results indicate that cascade ROS generation antitumor-drug effectively inhibit tumor growth. This design with reactions offers promising strategy enhance efficacy.

Language: Английский

Citations

246
Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies DOI Creative Commons
Hailong Tian, Tingting Zhang, Siyuan Qin

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Sept. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Language: Английский

Citations

246