Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(21), P. 13454 - 13619

Published: Sept. 28, 2021

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is photochemical-based treatment approach that involves the use of light combined with light-activated chemical, referred as PS. Attractively, PDT one alternatives conventional cancer due its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although concept photosensitizer-based photodynamic has been widely adopted clinical trials bioimaging, until now, our surprise, there no relevant article on rational designs organic PDT. Furthermore, most published articles focused nanomaterials nanotechnology based traditional PSs. Therefore, this aimed at reporting recent strategies develop innovative enhanced therapy, each example described detail instead providing only general overview, typically done previous reviews PDT, provide intuitive, vivid, specific insights readers.

Language: Английский

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Phage-Guided Targeting, Discriminative Imaging, and Synergistic Killing of Bacteria by AIE Bioconjugates

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(8), P. 3959 - 3969

Published: Jan. 30, 2020

New agents with particular specificity toward targeted bacteria and superefficacy in antibacterial activity are urgently needed facing the crisis of worldwide antibiotic resistance. Herein, a novel strategy by equipping bacteriophage (PAP) photodynamic inactivation (PDI)-active AIEgens (luminogens aggregation-induced emission property) was presented to generate type AIE–PAP bioconjugate superior capability for both imaging synergistic killing certain species bacteria. The targeting ability inherited from enabled bioconjugates specifically recognize host preserved infection phage itself. Meanwhile, AIE characteristic empowered them monitoring functionality, real-time tracking their interactions targets therefore realized via convenient fluorescence imaging. More importantly, PDI-active could serve as powerful situ photosensitizers producing high-efficiency reactive oxygen (ROS) under white light irradiation. As result, selective antibiotic-sensitive multi-drug-resistant (MDR) were successfully achieved vitro vivo tests excellent biocompatibility. This AIE–phage integrated would diversify existing pool inspire development promising drug candidates future.

Language: Английский

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<p>Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment</p>

International Journal of Nanomedicine, Journal Year: 2020, Volume and Issue: Volume 15, P. 1903 - 1914

Published: March 1, 2020

Background: Cancer is one of the major causes death and difficult to cure using existing clinical therapies. Clinical cancer treatments [such as surgery, chemotherapy (CHT), radiotherapy (RT) immunotherapy (IT)] are widely used but they have limited therapeutic effects unavoidable side effects. Recently, development novel nanomaterials offers a platform for combinational therapy (meaning combination two or more agents) which promising approach therapy. Recent studies demonstrated several types suitable photothermal (PTT) based on near-infrared (NIR) light-responsive system. PTT possesses favorable properties such being low in cost, having high temporospatial control with minimal invasiveness. However, short NIR light penetration depth limits its functions. Methods: In this review, due their promise, we focus inorganic hollow mesoporous silica nanoparticles (HMSNs), tungsten sulfide quantum dots (WS 2 QDs), gold nanorods (AuNRs)] combining CHT, RT IT treatment, aiming provide comprehensive understanding PTT-based Results: This review found much evidence use Conclusion: Under synergistic effects, nanomaterial-based exhibit enhanced compared PTT, RT, PDT alone should be further investigated field. Keywords: agents, hyperthermia, chemotherapy, radiotherapy, immunotherapy, photodynamic

Language: Английский

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Killing G(+) or G(−) Bacteria? The Important Role of Molecular Charge in AIE‐Active Photosensitizers

Small Methods, Journal Year: 2020, Volume and Issue: 4(7)

Published: April 6, 2020

Abstract Bacterial infections pose a serious threat to human health. Photodynamic therapy is an effective medical treatment solve the problems raised by antibiotic resistant bacteria. But it not easy have photosensitizers (PSs) that can simultaneously produce efficient fluorescence and reactive oxygen species. Traditional PSs show compromised performances due aggregation‐caused quenching effect in aqueous media, however, luminogens with aggregation‐induced emission (AIE) inherently achieve high ROS generation. In addition, electrostatic interaction generally accepted be responsible for initial targeting of AIE PSs, roles molecular charges on antibacterial efficiency are rarely considered. Herein, two red‐emissive same luminogenic core but carrying different number positive designed, their performance killing mechanism toward Gram‐positive (G(+)) Gram‐negative (G(−)) bacteria investigated. The highly singlet generation clearly image selectively kill over mammalian cells. With increase improvement great against G(−) bacteria, negligible G(+) This research will provide new insight into rational design materials.

Language: Английский

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Noncancerous disease-targeting AIEgens

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(3), P. 1024 - 1067

Published: Jan. 1, 2023

Schematic diagram of noncancerous disease-targeting AIEgens.

Language: Английский

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Biofilm-Responsive Polymeric Nanoparticles with Self-Adaptive Deep Penetration for In Vivo Photothermal Treatment of Implant Infection

Chemistry of Materials, Journal Year: 2020, Volume and Issue: 32(18), P. 7725 - 7738

Published: Aug. 19, 2020

Biofilm can protect bacteria from immune attacks and antibiotic inhibition, bacterial biofilm hosted in implanted materials medical devices is a serious threat for modern system. Herein, we report biofilm-responsive caged guanidine nanoparticles (CGNs) to deeply penetrate accumulate biofilm, then efficient photothermal eradication of achieved upon NIR laser irradiation via the proof-of-concept formulation agents CGNs. In physiological conditions blood circulation, CGNs are negatively charged by masking positive charge covalent modification with acid-cleavable moieties, exhibiting high biocompatibility minimal hemolysis. Whereas circulation passive accumulation at infected implant sites, self-adaptive acidic release protective caging group expose native which promote nanoparticle deep penetration adhesion as well membrane fusion. After that, remarkable effect conversion efficiency ∼40.9% eradicate irradiation. It efficiently treat S. aureus biofilm-infected catheters vivo only one single treatment mouse model, ∼99.6% inhibition ratio. Apart this work, current guanidine-caged responsive polymeric promising general vectors resistant pathogens medicine daily healthcare.

Language: Английский

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Innovative Synthetic Procedures for Luminogens Showing Aggregation‐Induced Emission

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(29), P. 15724 - 15742

Published: May 20, 2020

Abstract As a consequence of their intrinsic advantageous properties, luminogens that show aggregation‐induced emission (AIEgens) have received increasing global interest for wide range applications. Whereas general synthetic methods towards AIEgens largely rely on tedious procedures and limited reaction types, various innovative now emerged as complementary, even alternative, strategies. In this Review, we systematically highlight advancements made in metal‐catalyzed functionalization metal‐free‐promoted pathways the construction over past five years, briefly illustrate new perspectives area. The development will enable facile synthesis with great structural diversity multifunctional

Language: Английский

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Planar AIEgens with Enhanced Solid‐State Luminescence and ROS Generation for Multidrug‐Resistant Bacteria Treatment

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(25), P. 10179 - 10185

Published: Feb. 5, 2020

Abstract Planar luminogens have encountered difficulties in overcoming intrinsic aggregation‐caused emission quenching by intermolecular π‐π stacking interactions. Although excited‐state double‐bond reorganization (ESDBR) can guide us on designing planar aggregation‐induced (AIE) (AIEgens), its mechanism has yet been elucidated. Major challenges the field include methods to efficiently restrict ESDBR and enhance AIE performance without using bulky substituents (e.g., tetraphenylethylene triphenylamine). In this study, we rationally developed fluoro‐substituent AIEgens with stronger H‐bonding interaction for restricted molecular motions increased crystal density, leading decreased nonradiative decay rate one order of magnitude. The adjusted properties also show a corresponding response variation viscosity. Furthermore, their reactive oxygen species (ROS) generations discovered. application such AIEgen treating multidrug‐resistant bacteria demonstrated mouse model. relationship between ROS generation distinct E / Z ‐configurational behaviors further understood, providing design principle synthesizing AIEgen‐based photosensitizers.

Language: Английский

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BioAIEgens derived from rosin: how does molecular motion affect their photophysical processes in solid state?

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: March 19, 2021

Abstract The exploration of artificial luminogens with bright emission has been fully developed the advancement synthetic chemistry. However, many them face problems like weakened in aggregated state as well poor renewability and sustainability. Therefore, development renewable sustainable anti-quenching function solid state, to unveil key factors that influence their luminescence behavior become highly significant. Herein, a new class natural rosin-derived aggregation-induced property (AIEgens) have facilely obtained good biocompatibility targeted organelle imaging capability photochromic state. Mechanistic study indicates introduction alicyclic moiety helps suppress excited-state molecular motion enhance solid-state emission. current work fundamentally elucidates role luminogen design practically demonstrates source large-scalely obtain biocompatible AIEgens.

Language: Английский

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In vivophotothermal inhibition of methicillin-resistantStaphylococcus aureusinfection byin situtemplated formulation of pathogen-targeting phototheranostics

Nanoscale, Journal Year: 2020, Volume and Issue: 12(14), P. 7651 - 7659

Published: Jan. 1, 2020

Herein, pathogen-targeting phototheranostic nanoparticles, Van-OA@PPy, arein situdeveloped for efficient elimination of MRSA infection, which is reflected by dual-modality magnetic resonance and photoacoustic imaging.

Language: Английский

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