Molecular Biology Reports, Journal Year: 2021, Volume and Issue: 49(7), P. 6789 - 6801
Published: Oct. 31, 2021
Language: Английский
Nature Reviews Nephrology, Journal Year: 2022, Volume and Issue: 18(10), P. 643 - 662
Published: Aug. 16, 2022
Language: Английский
Citations
122
Antioxidants and Redox Signaling, Journal Year: 2018, Volume and Issue: 29(4), P. 355 - 376
Published: Jan. 16, 2018
Altered activities of long noncoding RNAs (lncRNAs) have been implicated in the regulation microRNAs. microRNA-27a (miR-27a) upregulation has shown to induce endoplasmic reticulum (ER) stress podocyte injury diabetic nephropathy (DN). Herein, we aim interrogate mutually regulated network miR-27a with intergenic RNA 1619 (LINC01619) and target gene.LINC01619 downregulation was found human DN renal biopsy tissues contributed proteinuria diminished function. LINC01619 expressed cytoplasm involved ER signaling pathway. exerted biological function by serving as a "sponge" for miR-27a, which negatively targeted forkhead box protein O1 (FOXO1) activated stress. In rats high-glucose cultured podocytes, triggered oxidative injuries demonstrated increased apoptosis, diffuse foot process effacement, decreased Innovation Conclusion: This study demonstrates that functions competing endogenous regulates miR-27a/FOXO1-mediated DN. Antioxid. Redox Signal. 29, 355-376.
Language: Английский
Citations
106
Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)
Published: April 22, 2021
Language: Английский
Citations
101
Genes, Journal Year: 2020, Volume and Issue: 11(2), P. 211 - 211
Published: Feb. 18, 2020
Two class of drugs 1) angiotensin-converting enzyme inhibitors (ACEis) and 2) angiotensin II receptor blockers (ARBs) are well-known conventional that can retard the progression chronic nephropathies to end-stage renal disease. However, there is a lack comparative studies on effects ACEi versus ARB fibrosis. Here, we observed ameliorated fibrosis by mitigating DPP-4 TGFβ signaling, whereas, did not show. Moreover, combination N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP), one substrates ACE, with slightly enhanced inhibitory associated-TGFβ signaling. Further, comprehensive miRome analysis in kidneys ACEi+AcSDKP (combination) treatment revealed emergence miR-29s miR-let-7s as key antifibrotic players. Treatment cultured cells alone or AcSDKP prevented downregulated expression induced stimulation. Interestingly, also restored miR-29 miR-let-7 family cross-talk endothelial cells, an effect shared suggesting may be partially involved anti-mesenchymal action ACEi. The results present study promise advance our understanding how regulates microRNAs crosstalk associated-fibrogenic processes which critical event development diabetic kidney
Language: Английский
Citations
71
Acta Biochimica et Biophysica Sinica, Journal Year: 2021, Volume and Issue: 54(2), P. 163 - 172
Published: Dec. 23, 2021
Diabetic nephropathy (DN), which is a common microvascular complication with high incidence in diabetic patients, greatly increases the mortality of patients. With further study on DN, it found that epigenetics plays crucial role pathophysiological process DN. Epigenetics has an important impact development DN through variety mechanisms, and promotes generation maintenance metabolic memory, thus ultimately leading to poor prognosis. In this review we discuss methylation DNA, modification histone, regulation non-coding RNA involved progress cell dysfunction, inflammation fibrosis kidney, lead deterioration
Language: Английский
Citations
62
World Journal of Diabetes, Journal Year: 2021, Volume and Issue: 12(5), P. 524 - 540
Published: May 6, 2021
Lipid dysmetabolism is one of the main features diabetes mellitus and manifests by dyslipidemia as well ectopic accumulation lipids in various tissues organs, including kidney. Research suggests that impaired cholesterol metabolism, increased lipid uptake or synthesis, fatty acid oxidation, droplet an imbalance biologically active sphingolipids (such ceramide, ceramide-1-phosphate sphingosine-1-phosphate) contribute to development diabetic kidney disease (DKD). Currently, literature both quality quantity are associated with DKD reactive oxygen species production, oxidative stress, inflammation, cell death. Therefore, control renal a very important therapeutic goal, which needs be archived. This article will review some recent advances leading better understanding mechanisms role particular DKD.
Language: Английский
Citations
60
Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 9
Published: Jan. 4, 2022
Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and 2 diabetes mellitus (T1DM, T2DM) the second major cause end-stage kidney disease. DN can lead to hypertension, edema, proteinuria. In some cases, even progress failure, life-threatening condition. The precise etiology pathogenesis remain unknown, although multiple factors are believed be involved. main pathological manifestations include mesangial expansion, thickening glomerular basement membrane, podocyte injury. Eventually, these will glomerulosclerosis, thus affecting renal function. There an urgent need develop new strategies for prevention treatment DN. Existing evidence shows that Wnt signaling cascade plays key role in regulating development Previous studies focused on canonical pathway Subsequently, accumulated mechanism non-canonical indicated Wnt/Ca 2+ Wnt/PCP also have essential roles progression this review, we summarize specific mechanisms occurrence injury, cell fibrosis. Also, elucidate significance process DN, uncovered supporting critical development.
Language: Английский
Citations
52
Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(23), P. 7349 - 7349
Published: Nov. 27, 2023
The worldwide occurrence of diabetic kidney disease (DKD) is swiftly rising, primarily attributed to the growing population individuals affected by type 2 diabetes. This surge has been transformed into a substantial global concern, placing additional strain on healthcare systems already grappling with significant demands. pathogenesis DKD intricate, originating hyperglycemia, which triggers various mechanisms and pathways: metabolic, hemodynamic, inflammatory, fibrotic ultimately lead renal damage. Within each pathway, several mediators contribute development structural functional changes. Some these mediators, such as inflammatory cytokines, reactive oxygen species, transforming growth factor β are shared among different pathways, leading overlap interaction between them. While current treatment options for have shown advancement over previous strategies, their effectiveness remains somewhat constrained patients still experience residual risk progression. Therefore, comprehensive grasp molecular underlying onset progression imperative continued creation novel groundbreaking therapies this condition. In review, we discuss achievements in fundamental research, particular emphasis individual factors recent developments treatment.
Language: Английский
Citations
26
International Journal of Endocrinology, Journal Year: 2018, Volume and Issue: 2018, P. 1 - 20
Published: Jan. 1, 2018
In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting kidney, retina, and peripheral neurons. Compelling evidence indicates that abnormally expressed pivotal roles in key pathogenic processes such fibrosis, apoptosis, inflammation, angiogenesis. Moreover, clinical research into innovative both diagnostic prognostic tools suggests circulating possible novel noninvasive markers complications. this review, we summarize current knowledge understanding role injury to bed discuss biomarkers
Language: Английский
Citations
72
Clinica Chimica Acta, Journal Year: 2019, Volume and Issue: 491, P. 59 - 65
Published: Jan. 11, 2019
Language: Английский
Citations
65