ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut DOI
Mengze Lyu, Hiroaki Suzuki, Lan Kang

et al.

Nature, Journal Year: 2022, Volume and Issue: 610(7933), P. 744 - 751

Published: Sept. 7, 2022

Language: Английский

The microbiota in adaptive immune homeostasis and disease DOI
Kenya Honda, Dan R. Littman

Nature, Journal Year: 2016, Volume and Issue: 535(7610), P. 75 - 84

Published: July 5, 2016

Language: Английский

Citations

1612
Homeostatic Immunity and the Microbiota DOI Creative Commons
Yasmine Belkaid, Oliver J. Harrison

Immunity, Journal Year: 2017, Volume and Issue: 46(4), P. 562 - 576

Published: April 1, 2017

Language: Английский

Citations

1030
Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis DOI
Xinyang Song,

Ximei Sun,

Sungwhan F. Oh

et al.

Nature, Journal Year: 2019, Volume and Issue: 577(7790), P. 410 - 415

Published: Dec. 25, 2019

Language: Английский

Citations

744
Regulatory T cells in autoimmune disease DOI
Margarita Dominguez‐Villar, David A. Hafler

Nature Immunology, Journal Year: 2018, Volume and Issue: 19(7), P. 665 - 673

Published: June 14, 2018

Language: Английский

Citations

608
IL-17 and IL-17-producing cells in protection versus pathology DOI Open Access
Kingston H. G. Mills

Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 23(1), P. 38 - 54

Published: July 5, 2022

Language: Английский

Citations

553
Development and maintenance of intestinal regulatory T cells DOI
Takeshi Tanoue, Koji Atarashi, Kenya Honda

et al.

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 16(5), P. 295 - 309

Published: April 18, 2016

Language: Английский

Citations

491
Tissue Tregs DOI Open Access
Marisella Panduro, Christophe Benoist, Diane Mathis

et al.

Annual Review of Immunology, Journal Year: 2016, Volume and Issue: 34(1), P. 609 - 633

Published: May 11, 2016

The immune system is responsible for defending an organism against the myriad of microbial invaders it constantly confronts. It has become increasingly clear that a second major function: maintenance organismal homeostasis. Foxp3 + CD4 regulatory T cells (Tregs) are important contributors to both these critical activities, defense being primary purview Tregs circulating through lymphoid organs, and homeostasis ensured mainly by their counterparts residing in parenchymal tissues. This review focuses on so-called tissue Tregs. We first survey existing information phenotype, function, sustaining factors, human equivalents three best-characterized tissue-Treg populations—those operating visceral adipose tissue, skeletal muscle, colonic lamina propria. then attempt distill general principles from this body work—as concerns provenance, local adaptation, molecular sustenance, targets action Tregs, particular.

Language: Английский

Citations

476
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont DOI

Mo Xu,

Maria Pokrovskii, Yi Ding

et al.

Nature, Journal Year: 2018, Volume and Issue: 554(7692), P. 373 - 377

Published: Feb. 1, 2018

Language: Английский

Citations

442
Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice DOI Creative Commons
Graham J. Britton, Eduardo J. Contijoch, Ilaria Mogno

et al.

Immunity, Journal Year: 2019, Volume and Issue: 50(1), P. 212 - 224.e4

Published: Jan. 1, 2019

Language: Английский

Citations

428
T cells in health and disease DOI Creative Commons
Lina Sun, Yanhong Su, Anjun Jiao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: June 19, 2023

T cells are crucial for immune functions to maintain health and prevent disease. cell development occurs in a stepwise process the thymus mainly generates CD4

Language: Английский

Citations

380