Proceedings of the National Academy of Sciences,
Journal Year:
2014,
Volume and Issue:
111(43), P. 15514 - 15519
Published: Oct. 13, 2014
Significance
Sensors
of
the
innate
immune
system
trigger
induction
inflammatory
responses
upon
infection
and
cellular
stress.
One
such
sensor
is
inflammasome
pathway,
which
best
described
for
its
role
in
production
cytokines
IL-1β
IL-18.
Other
effector
functions
pathway
remain
less
well
defined,
here
we
show
that
activation
this
leads
to
mitochondrial
damage
dismantling
organelle.
We
link
another
inflammasome-regulated
process
called
pyroptosis,
a
proinflammatory
form
cell
death.
In
summary,
characterize
during
relevance
host
defense
other
physiological
pathophysiological
settings.
Immunological Reviews,
Journal Year:
2017,
Volume and Issue:
277(1), P. 61 - 75
Published: April 30, 2017
Summary
Cell
death
is
a
fundamental
biological
phenomenon
that
essential
for
the
survival
and
development
of
an
organism.
Emerging
evidence
also
indicates
cell
contributes
to
immune
defense
against
infectious
diseases.
Pyroptosis
form
inflammatory
programmed
pathway
activated
by
human
mouse
caspase‐1,
caspase‐4
caspase‐5,
or
caspase‐11.
These
caspases
are
used
host
control
bacterial,
viral,
fungal,
protozoan
pathogens.
requires
cleavage
activation
pore‐forming
effector
protein
gasdermin
D
caspases.
Physical
rupture
causes
release
pro‐inflammatory
cytokines
IL
‐1β
‐18,
alarmins
endogenous
danger‐associated
molecular
patterns,
signifying
potential
pyroptosis.
Here,
we
describe
central
role
pyroptosis
in
mediating
immunity
infection
clearance
Immunological Reviews,
Journal Year:
2015,
Volume and Issue:
265(1), P. 130 - 142
Published: April 16, 2015
Summary
Inflammatory
caspases
play
a
central
role
in
innate
immunity
by
responding
to
cytosolic
signals
and
initiating
twofold
response.
First,
caspase‐1
induces
the
activation
secretion
of
two
prominent
pro‐inflammatory
cytokines,
interleukin‐1β
(
IL
‐1β)
‐18.
Second,
either
or
caspase‐11
can
trigger
form
lytic,
programmed
cell
death
called
pyroptosis.
Pyroptosis
operates
remove
replication
niche
intracellular
pathogens,
making
them
susceptible
phagocytosis
killing
secondary
phagocyte.
However,
aberrant,
systemic
pyroptosis
vivo
may
contribute
sepsis.
Emphasizing
efficiency
inflammasome
detection
microbial
infections,
many
pathogens
have
evolved
avoid
subvert
This
review
focuses
on
molecular
morphological
characteristics
individual
inflammasomes
their
contribution
defense
against
infection
mice
humans.
Cell Death and Disease,
Journal Year:
2019,
Volume and Issue:
10(9)
Published: Sept. 9, 2019
Abstract
Programmed
cell
death
(PCD)
refers
to
the
way
in
which
cells
die
depending
on
specific
genes
encoding
signals
or
activities.
Apoptosis,
autophagy,
and
pyroptosis
are
all
mechanisms
of
PCD.
Among
these
mechanisms,
is
mediated
by
gasdermin
family,
accompanied
inflammatory
immune
responses.
The
relationship
between
cancer
complex,
effects
vary
different
tissues
genetic
backgrounds.
On
one
hand,
can
inhibit
occurrence
development
tumors;
other
as
a
type
proinflammatory
death,
form
suitable
microenvironment
for
tumor
growth
thus
promote
growth.
In
addition,
induction
also
considered
potential
treatment
strategy.
Studies
have
shown
that
DFNA5
(nonsyndromic
hearing
impairment
protein
5)/GSDME
(Gasdermin-E)
mRNA
methylation
results
lower
expression
levels
DFNA5/GSDME
most
than
normal
cells,
making
it
difficult
activate
cells.
During
malignant
tumors,
appropriate
chemotherapeutic
drugs
be
selected
according
DFNA5/GSDME,
upregulated
thereby
increasing
sensitivity
reducing
drug
resistance.
Therefore,
induced
may
play
predominant
role
cancer.
Here,
we
review
latest
research
anti-
protumor
its
applications
treatment.
