Direction selectivity in retinal bipolar cell axon terminals DOI Creative Commons
Akihiro Matsumoto,

Weaam Agbariah,

Stella Solveig Nolte

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(18), P. 2928 - 2942.e8

Published: Aug. 13, 2021

The ability to encode the direction of image motion is fundamental our sense vision. Direction selectivity along four cardinal directions thought originate in direction-selective ganglion cells (DSGCs) because directionally tuned GABAergic suppression by starburst cells. Here, utilizing two-photon glutamate imaging measure synaptic release, we reveal that all arises earlier than expected at bipolar cell outputs. Individual contained distinct populations axon terminal boutons with different preferred directions. We further show this bouton-specific tuning relies on cholinergic excitation from and inhibition wide-field amacrine DSGCs received both aligned inputs untuned among heterogeneously glutamatergic bouton populations. Thus, directional excitatory visual pathway incrementally refined terminals their recipient DSGC dendrites two neurotransmitters co-released

Language: Английский

Understanding the retinal basis of vision across species DOI
Tom Baden, Thomas Euler, Philipp Berens

et al.

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 21(1), P. 5 - 20

Published: Nov. 28, 2019

Language: Английский

Citations

280
The Brain from Inside Out DOI
György Buzsáki

Oxford University Press eBooks, Journal Year: 2019, Volume and Issue: unknown

Published: June 17, 2019

Abstract The Brain from Inside Out takes a critical look at contemporary brain research and reminds us that theoretical framework does matter. Current technology-driven neuroscience is still largely fueled by an empiricist philosophy assuming the brain’s goal to perceive, represent world, learn truth. An inevitable consequence of this assumption decision-making homunculus wedged between our perception actions. In contrast, advocates fundamental function induce actions predict consequences those support survival prosperity host. Brains constantly test their hypotheses producing rather than searching for veridical objective world. Only can provide second opinion about relevance sensory inputs meaning interpretation inputs. inside-out framework, it not sensations teach build up its circuits. Instead, comes with preconfigured self-organized dynamics constrains how acts views Both anatomical physiological organizations are characterized enormous diversity which spans several orders magnitude. two ends continuous landscape give rise apparently distinct qualitative features. A small core strongly interconnected, highly active neurons provides fast “good-enough” answers in needy situations generalizations, whereas detailed precise solutions rely on contribution more isolated sluggish majority. non-egalitarian organization, preexisting nonsense patterns become meaningful through action-based experience. offers alternative strategy investigate operations cognitive faculties, as opposed outside-in approach explores preconceived ideas map onto structures.

Language: Английский

Citations

278
Digital Museum of Retinal Ganglion Cells with Dense Anatomy and Physiology DOI Creative Commons
J. Alexander Bae, Shang Mu, Jinseop S. Kim

et al.

Cell, Journal Year: 2018, Volume and Issue: 173(5), P. 1293 - 1306.e19

Published: May 1, 2018

Language: Английский

Citations

248
Zebrafish Differentially Process Color across Visual Space to Match Natural Scenes DOI Creative Commons
Maxime JY Zimmermann, Noora Emilia Nevala, Takeshi Yoshimatsu

et al.

Current Biology, Journal Year: 2018, Volume and Issue: 28(13), P. 2018 - 2032.e5

Published: June 21, 2018

Language: Английский

Citations

201
Unified classification of mouse retinal ganglion cells using function, morphology, and gene expression DOI Creative Commons

Jillian J. Goetz,

Zachary F. Jessen,

Anne Jacobi

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 40(2), P. 111040 - 111040

Published: July 1, 2022

Classification and characterization of neuronal types are critical for understanding their function dysfunction. Neuronal classification schemes typically rely on measurements electrophysiological, morphological, molecular features, but aligning such datasets has been challenging. Here, we present a unified mouse retinal ganglion cells (RGCs), the sole output neurons. We use visually evoked responses to classify 1,859 RGCs into 42 types. also obtain morphological or transcriptomic data from subsets these align functional publicly available datasets. create an online database that allows users browse download light using machine learning algorithm. This work provides resource studies RGCs, upstream circuits in retina, projections brain, establishes framework future efforts open distribution.

Language: Английский

Citations

168
Eye saccades align optic flow with retinal specializations during object pursuit in freely moving ferrets DOI Creative Commons
Damian J. Wallace,

Kay-Michael Voit,

Danuza de Oliveira Machado

et al.

Current Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Highlights•Saccades during target pursuit align area centralis with intended direction of travel•Saccades simultaneously also retinal pattern optic flow•Post-saccade eye and head rotation reduce image blur limit information loss•Tree shrews, mice, rats have the same coordinated kineticsSummaryDuring prey pursuit, how rotations, such as saccades, enable continuous tracking erratically moving targets while enabling an animal to navigate through environment is unknown. To better understand this, we measured rotations in freely running ferrets behavior. By all environmental features, reconstructed animal's visual fields their relationship structures. In fields, position clustered on around high-acuity location, centralis, surprisingly, this cluster was not significantly shifted by digital removal either exclusively elicited when made turns, or that were tightly synchronized saccades. Here, show that, saccades did fixate they instead aligned travel. This features flow pattern, focus expansion, used for navigation many species. While initially rotated eyes turn, followed countering ongoing rotation, which reduced limited loss across field turns. As rotational tree rats, suggest these counter-rotations are a generalized mechanism mammals complex environments pursuit.Graphical abstract

Language: Английский

Citations

2
Whole-Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration DOI Creative Commons
Émilie Macé, Gabriel Montaldo, Stuart Trenholm

et al.

Neuron, Journal Year: 2018, Volume and Issue: 100(5), P. 1241 - 1251.e7

Published: Dec. 1, 2018

Highlights•Functional ultrasound enables imaging whole-brain activity during mouse behavior•Activity in 87 brain regions are modulated the optokinetic reflex•Reflex-related were identified by perturbing retinal direction selectivity•A subset of these regions, all thalamus, independent eye motionSummaryLarge numbers active behaviors. A high-resolution, brain-wide map could identify involved specific We have developed functional to record behaving mice at a resolution ∼100 μm. detected visual stimulation that evoked reflex, visuomotor behavior stabilizes gaze both horizontally and vertically. Using genetic model congenital nystagmus incapable generating horizontal we whose was reflex dependent. By blocking motion control animals, further separated depended on reflex's motor output. Remarkably, reflex-dependent but motion-independent located thalamus. Our work identifies modules sensorimotor integration provides an experimental approach monitor normal disease states.

Language: Английский

Citations

130
Sensorimotor control of standing balance DOI
Patrick A. Forbes, Anthony Chen,

Jean‐Sébastien Blouin

et al.

Handbook of clinical neurology, Journal Year: 2018, Volume and Issue: unknown, P. 61 - 83

Published: Jan. 1, 2018

Language: Английский

Citations

121
A Fine-Scale Functional Logic to Convergence from Retina to Thalamus DOI Creative Commons
Liang Liang, Alex Fratzl,

Glenn J. Goldey

et al.

Cell, Journal Year: 2018, Volume and Issue: 173(6), P. 1343 - 1355.e24

Published: May 1, 2018

Language: Английский

Citations

114
Neural Mechanisms of Motion Processing in the Mammalian Retina DOI Creative Commons
Wei Wei

Annual Review of Vision Science, Journal Year: 2018, Volume and Issue: 4(1), P. 165 - 192

Published: Aug. 10, 2018

Visual motion on the retina activates a cohort of retinal ganglion cells (RGCs). This population activity encodes multiple streams information extracted by parallel circuits. Motion processing in is best studied direction-selective circuit. The main focus this review neural basis direction selectivity, which has been investigated unprecedented detail using state-of-the-art functional, connectomic, and modeling methods. Mechanisms underlying encoding other features broader RGC populations are also discussed. Recent discoveries at both single-cell levels highlight dynamic stimulus-dependent engagement mechanisms that collectively implement robust detection under diverse visual conditions.

Language: Английский

Citations

106