Functional diversity for body actions in the mesencephalic locomotor region DOI Creative Commons
Manuel J. Ferreira‐Pinto, Harsh Kanodia, Antonio Falasconi

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(17), P. 4564 - 4578.e18

Published: July 23, 2021

The mesencephalic locomotor region (MLR) is a key midbrain center with roles in locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant Parkinson's disease (PD), debate on its function remains. Here, we reveal the existence of functionally diverse neuronal populations distinct control body movements. We identify two spatially intermingled glutamatergic separable by axonal projections, mouse genetics, activity profiles, motor functions. Most spinally projecting MLR neurons encoded full-body behavior rearing. Loss- gain-of-function optogenetic perturbation experiments establish for these controlling extension. In contrast, Rbp4-transgene-positive project an ascending direction to basal ganglia, preferentially encode forelimb behaviors handling grooming, exhibit role modulating movement. Thus, contains subpopulations stratified projection target exhibiting action not restricted

Language: Английский

Networking brainstem and basal ganglia circuits for movement DOI
Silvia Arber, Rui M. Costa

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(6), P. 342 - 360

Published: April 14, 2022

Language: Английский

Citations

138
Brainstem Circuits for Locomotion DOI
Roberto Leiras, Jared M. Cregg, Ole Kiehn

et al.

Annual Review of Neuroscience, Journal Year: 2022, Volume and Issue: 45(1), P. 63 - 85

Published: Jan. 5, 2022

Locomotion is a universal motor behavior that expressed as the output of many integrated brain functions. organized at several levels nervous system, with brainstem circuits acting gate between areas regulating innate, emotional, or motivational locomotion and executive spinal circuits. Here we review recent advances on involved in controlling locomotion. We describe how delineated command govern start, speed, stop, steering also discuss these pathways interface cord diverse important for context-specific selection A recurrent theme need to establish functional connectome from Finally, point unresolved issues concerning function locomotor control.

Language: Английский

Citations

91
Induction of flight via midbrain projections to the cuneiform nucleus DOI Creative Commons
Emmy Tsang,

Camilla Orlandini,

Rahul Sureka

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(2), P. e0281464 - e0281464

Published: Feb. 16, 2023

The dorsal periaqueductal gray is a midbrain structure implicated in the control of defensive behaviors and processing painful stimuli. Electrical stimulation or optogenetic activation excitatory neurons results freezing flight behavior at low high intensity, respectively. However, output structures that mediate these remain unconfirmed. Here we carried out targeted classification neuron types using multiplex situ sequencing then applied cell-type projection-specific to identify projections from grey cuneiform nucleus promoted goal-directed behavior. These data confirmed descending outputs serve as trigger for directed escape

Language: Английский

Citations

42
Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice DOI Creative Commons
Jared M. Cregg, Simrandeep Kaur Sidhu, Roberto Leiras

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(4), P. 716 - 727

Published: Feb. 12, 2024

Abstract The basal ganglia are essential for executing motor actions. How the engage spinal networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons required turning gait programs, suggesting that gaits organized by executed via this descending pathway. Performing deep brainstem recordings of Gi Ca 2+ activity in adult mice, we show striatal projection initiate a dominant crossed pathway to on contralateral side. Using intersectional viral tracing and cell-type-specific modulation, uncover principal ganglia–spinal cord locomotor asymmetries mice: → pontine reticular nucleus, oral part (PnO) cord. Modulating restricted PnO restores competence upon damage, dysfunction may contribute debilitating deficits observed Parkinson’s disease. Our results reveal stratified circuit architecture underlying critical program.

Language: Английский

Citations

20
Neural circuit mechanisms underlying context-specific halting in Drosophila DOI Creative Commons

Neha Sapkal,

Nino Mancini,

Divya Sthanu Kumar

et al.

Nature, Journal Year: 2024, Volume and Issue: 634(8032), P. 191 - 200

Published: Oct. 2, 2024

Language: Английский

Citations

18
Connecting neuronal circuits for movement DOI
Silvia Arber, Rui M. Costa

Science, Journal Year: 2018, Volume and Issue: 360(6396), P. 1403 - 1404

Published: June 28, 2018

Dedicated neuronal circuits mediate execution, choice, and coordination of body action

Language: Английский

Citations

146
Spatial and Temporal Locomotor Learning in Mouse Cerebellum DOI Creative Commons
Dana Darmohray, Jovin R. Jacobs, Hugo Gravato Marques

et al.

Neuron, Journal Year: 2019, Volume and Issue: 102(1), P. 217 - 231.e4

Published: Feb. 19, 2019

Language: Английский

Citations

138
Connecting Circuits for Supraspinal Control of Locomotion DOI Creative Commons
Manuel J. Ferreira‐Pinto,

Ludwig Ruder,

Paolo Capelli

et al.

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 361 - 374

Published: Oct. 1, 2018

Language: Английский

Citations

128
Brainstem neurons that command mammalian locomotor asymmetries DOI
Jared M. Cregg, Roberto Leiras, Alexia Montalant

et al.

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(6), P. 730 - 740

Published: May 11, 2020

Language: Английский

Citations

128
Reticulospinal Systems for Tuning Motor Commands DOI Creative Commons
Robert M. Brownstone, Jeremy W. Chopek

Frontiers in Neural Circuits, Journal Year: 2018, Volume and Issue: 12

Published: April 18, 2018

The pontomedullary reticular formation is a key site responsible for integrating descending instructions to execute particular movements. indiscrete nature of this region has led not only some inconsistencies in nomenclature, but also difficulties understanding its role the control movement. In review, we first discuss nomenclature formation, and then examine reticulospinal motor command system through evolution. These neurons have direct monosynaptic connections with spinal interneurons motoneurons. We next review their roles postural adjustments, walking, sleep atonia, discussing movement activation or inhibition. propose that knowledge internal organization necessary understand how nervous tunes commands, will underlie strategies functional recovery following neurological injuries diseases.

Language: Английский

Citations

109