Bright Aggregation‐Induced‐Emission Dots for Targeted Synergetic NIR‐II Fluorescence and NIR‐I Photoacoustic Imaging of Orthotopic Brain Tumors DOI
Zonghai Sheng, Bing Guo, Dehong Hu

et al.

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(29)

Published: May 28, 2018

Abstract Precise diagnostics are of significant importance to the optimal treatment outcomes patients bearing brain tumors. NIR‐II fluorescence imaging holds great promise for brain‐tumor with deep penetration and high sensitivity. This requires development organic fluorescent agents quantum yield (QY), which is difficult achieve. Herein, design synthesis a new molecule aggregation‐induced‐emission (AIE) characteristics reported orthotopic imaging. Encapsulation in polymer matrix yields AIE dots showing very QY 6.2% large absorptivity 10.2 L g −1 cm at 740 nm an emission maximum near 1000 nm. Further decoration c‐RGD targeted dots, afford specific selective tumor uptake, signal/background ratio 4.4 resolution up 38 µm. The NIR facilitates NIR‐I photoacoustic intrinsically deeper than and, more importantly, precise tumor‐depth detection through intact scalp skull. research demonstrates molecules their dual cancer diagnostics.

Language: Английский

Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation DOI
Jing Li, Kanyi Pu

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(1), P. 38 - 71

Published: Nov. 2, 2018

Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Language: Английский

Citations

1044
Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics DOI
Shuqing He, Jun Song, Junle Qu

et al.

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 47(12), P. 4258 - 4278

Published: Jan. 1, 2018

Recent advances in the chemical design and synthesis of fluorophores second near-infrared biological window (NIR-II) for multimodal imaging theranostics are summarized highlighted this review article.

Language: Английский

Citations

869
First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows DOI
Zhenhua Hu, Cheng Fang, Bo Li

et al.

Nature Biomedical Engineering, Journal Year: 2019, Volume and Issue: 4(3), P. 259 - 271

Published: Dec. 23, 2019

Language: Английский

Citations

850
Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery DOI
Shoujun Zhu, Rui Tian,

Alexander L. Antaris

et al.

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(24)

Published: April 26, 2019

Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target variety of biological tissues processes. This review focuses on summarizing organic dyes emitting at transparency window termed the near-infrared-II (NIR-II) window, where minimal light interaction with surrounding allows photons travel nearly unperturbed throughout body. NIR-II fluorescence imaging overcomes penetration/contrast bottleneck in visible region, making it remarkable modality early diagnosis cancer highly sensitive tumor surgery. Due their convenient bioconjugation peptides/antibodies, molecular are desirable candidates targeted imaging, significantly overcoming autofluorescence/scattering issues deep tissue imaging. To promote clinical translation bioimaging, advancements high-performance small molecule-derived probes critically important. Here, molecules potential discussed, synthesis chemical structures dyes, optical properties behavior whole body detection surgery, as well microscopy A key perspective direction surgery is also discussed.

Language: Английский

Citations

814
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications DOI
Chunyan Li, Guangcun Chen, Yejun Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(35), P. 14789 - 14804

Published: Aug. 7, 2020

Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital capacity in the conventional wavelength range (400–950 nm) been restricted by extremely limited tissue penetration. To tackle this challenge, novel approach using fluorescence second near-infrared window (NIR-II, 1000–1700 developed past decade to achieve deep penetration and high-fidelity imaging, thus significant applications have begun emerge. In Perspective, we first examine recent discoveries challenges development of NIR-II fluorophores compatible apparatuses. Subsequently, advances bioimaging, biosensing, therapy such cutting-edge technique are highlighted. Finally, based on achievement representative studies, elucidate main concerns regarding give some advice prospects future applications.

Language: Английский

Citations

778
Recent Advances of Optical Imaging in the Second Near‐Infrared Window DOI

Kenry Kenry,

Yukun Duan, Bin Liu

et al.

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(47)

Published: Sept. 4, 2018

Abstract The near‐infrared window between 1000 and 1700 nm, commonly termed the “second (NIR‐II) window,” has quickly emerged as a highly attractive optical region for biological imaging. In contrast to conventional imaging in visible 400 700 well first NIR (NIR‐I) 900 NIR‐II offers numerous merits, including higher spatial resolution, deeper penetration depth, lower absorption scattering from substrates with minimal tissue autofluorescence. Noninvasive techniques, specifically fluorescence photoacoustic (PA) imaging, have embodied attractiveness of several agents demonstrating superior performance clinically approved NIR‐I agents. Consequently, been increasingly explored due its tremendous potential preclinical studies clinical utility. Herein, progress is reported. Starting highlighting importance spectral region, emergence latest development various PA probes their applications are then discussed. Perspectives on promises challenges facing this nascent yet exciting field given.

Language: Английский

Citations

700
Advances in nanomaterials for photodynamic therapy applications: Status and challenges DOI
Jianming Chen, Taojian Fan, Zhongjian Xie

et al.

Biomaterials, Journal Year: 2020, Volume and Issue: 237, P. 119827 - 119827

Published: Jan. 27, 2020

Language: Английский

Citations

627
Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury DOI
Jiaguo Huang, Jing Li, Yan Lyu

et al.

Nature Materials, Journal Year: 2019, Volume and Issue: 18(10), P. 1133 - 1143

Published: May 27, 2019

Language: Английский

Citations

608
Novel electrode technologies for neural recordings DOI
Guosong Hong, Charles M. Lieber

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(6), P. 330 - 345

Published: March 4, 2019

Language: Английский

Citations

585
Design of superior phototheranostic agents guided by Jablonski diagrams DOI
Guangxue Feng, Guoqiang Zhang, Dan Ding

et al.

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8179 - 8234

Published: Jan. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Language: Английский

Citations

584