Cellular uptake of nanoparticles: journey inside the cell

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 46(14), P. 4218 - 4244

Published: Jan. 1, 2017

Nanoscale materials are increasingly found in consumer goods, electronics, and pharmaceuticals. While these particles interact with the body myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions at cellular subcellular level. Nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell-cell communication, structure a manner dictated largely by phenomena nano-bio interface. Recent advances chemical synthesis have yielded new nanoscale precisely defined biochemical features, emerging analytical techniques shed light on nuanced context-dependent within cells. In this review, we provide an objective comprehensive account of our current understanding uptake NPs underlying parameters controlling nano-cellular interactions, along available to follow track processes.

Language: Английский

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Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985

Published: April 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Language: Английский

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Progress and challenges towards targeted delivery of cancer therapeutics

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: April 11, 2018

Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past few decades. However, compared to plethora of successful pre-clinical studies, only 15 passively targeted nanocarriers (NCs) been approved clinical use and none actively NCs advanced trials. Herein, we review principles behind determine potential reasons their limited translation success. We propose criteria considerations that must be taken into account development novel NCs. also highlight possible directions tumor targeting strategies.

Language: Английский

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Photodynamic therapy – mechanisms, photosensitizers and combinations

Biomedicine & Pharmacotherapy, Journal Year: 2018, Volume and Issue: 106, P. 1098 - 1107

Published: July 17, 2018

Language: Английский

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Cell Membrane Coating Nanotechnology

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(23)

Published: March 27, 2018

Abstract Nanoparticle‐based therapeutic, prevention, and detection modalities have the potential to greatly impact how diseases are diagnosed managed in clinic. With wide range of nanomaterials available, rational design nanocarriers on an application‐specific basis has become increasingly commonplace. Here, a comprehensive overview is provided emerging platform: cell‐membrane‐coating nanotechnology. As fundamental unit biology, cells carry out functions, including remarkable ability interface interact with their surrounding environment. Instead attempting replicate such functions via synthetic techniques, researchers now directly leveraging naturally derived cell membranes as means bestowing nanoparticles enhanced biointerfacing capabilities. This top‐down technique facile, highly generalizable, augment existing nanocarriers. Further, introduction natural membrane substrate onto surfaces enabled additional applications beyond those traditionally associated nanomedicine. Despite its relative youth, there exists impressive body literature coating, which covered here detail. Overall, still significant room for development, continue refine workflows while finding new exciting that can take advantage this developing technology.

Language: Английский

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Nanoparticles in the clinic: An update

Bioengineering & Translational Medicine, Journal Year: 2019, Volume and Issue: 4(3)

Published: Aug. 27, 2019

Nanoparticle drug delivery systems have been used in the clinic since early 1990's. Since that time, field of nanomedicine has evolved alongside growing technological needs to improve various therapeutics. Over these past decades, newer generations nanoparticles emerged are capable performing additional functions can enable treatment via new therapeutic modalities. In current clinical landscape, many generation reached trials and approved for indications. first issue Bioengineering & Translational Medicine 2016, we reviewed history, challenges nanoparticle systems. Here, provide a 3 year update on landscape highlight newly nanomedicines, status previous trials, technologies recently entered clinic.

Language: Английский

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Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

Nanoscale Research Letters, Journal Year: 2018, Volume and Issue: 13(1)

Published: Oct. 25, 2018

Nanoparticle science is rapidly changing the landscape of various scientific fields and defining new technological platforms. This perhaps even more evident in field nanomedicine whereby nanoparticles have been used as a tool for treatment diagnosis many diseases. However, despite tremendous benefit conferred, common pitfalls this technology its potential short long-term effects on human body. To understand these issues, studies carried out. review attempts to shed light some outcomes. The topics that were examined include different possible uptake pathways intracellular trafficking routes. Additionally, effect physicochemical properties nanoparticle such size, shape, charge surface chemistry determining mechanism biological function are also addressed.

Language: Английский

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Smart cancer nanomedicine

Nature Nanotechnology, Journal Year: 2019, Volume and Issue: 14(11), P. 1007 - 1017

Published: Nov. 1, 2019

Language: Английский

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Using immunotherapy to boost the abscopal effect

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(5), P. 313 - 322

Published: Feb. 16, 2018

Language: Английский

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Rethinking cancer nanotheranostics

Nature Reviews Materials, Journal Year: 2017, Volume and Issue: 2(7)

Published: May 9, 2017

Language: Английский

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