Every step of the way: integrins in cancer progression and metastasis

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(9), P. 533 - 548

Published: July 12, 2018

Language: Английский

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The exosome journey: from biogenesis to uptake and intracellular signalling

Cell Communication and Signaling, Journal Year: 2021, Volume and Issue: 19(1)

Published: April 23, 2021

Abstract The use of exosomes in clinical settings is progressively becoming a reality, as trials testing for diagnostic and therapeutic applications are generating remarkable interest from the scientific community investors. Exosomes small extracellular vesicles secreted by all cell types playing intercellular communication roles health disease transferring cellular cargoes such functional proteins, metabolites nucleic acids to recipient cells. An in-depth understanding exosome biology therefore essential ensure development based investigational products. Here we summarise most up-to-date knowkedge about complex biological journey biogenesis secretion, transport uptake their intracellular signalling. We delineate major pathways molecular players that influence each step physiology, highlighting routes interest, which will be benefit manipulation engineering. highlight main controversies field research: adequate definition, characterisation at plasma membrane. also common identified pitfalls affecting research development. Unravelling physiology key ultimate progression towards applications.

Language: Английский

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Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi

Nature Reviews Microbiology, Journal Year: 2015, Volume and Issue: 13(10), P. 620 - 630

Published: Sept. 1, 2015

Language: Английский

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Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

BioScience, Journal Year: 2015, Volume and Issue: 65(8), P. 783 - 797

Published: June 26, 2015

The release of extracellular vesicles (EVs), including exosomes and microvesicles, is a phenomenon shared by many cell types as means communicating with other cells also potentially removing contents. cargo EVs includes the proteins, lipids, nucleic acids, membrane receptors from which they originate. released into space can enter body fluids reach distant tissues. Once taken up neighboring and/or distal cells, transfer functional that may alter status recipient thereby contributing to both physiological pathological processes. In this article, we will focus on EV composition, mechanisms uptake, their biological effects cells. We discuss established recently developed methods used study EVs, isolation, quantification, labeling imaging protocols, well RNA analysis.

Language: Английский

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Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

Cancer and Metastasis Reviews, Journal Year: 2013, Volume and Issue: 32(3-4), P. 623 - 642

Published: May 24, 2013

Language: Английский

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Exosome Theranostics: Biology and Translational Medicine

Theranostics, Journal Year: 2017, Volume and Issue: 8(1), P. 237 - 255

Published: Nov. 20, 2017

Exosomes are common membrane-bound nanovesicles that contain diverse biomolecules, such as lipids, proteins, and nucleic acids.Exosomes derived from cells through exocytosis, ingested by target cells, can transfer biological signals between local or distant cells.Exosome secretion is a constitutive phenomenon involved in both physiological pathological processes determines the exosomal surface molecules contents.Hence, we exploit exosomes biomarkers, vaccines drug carriers modify them rationally for therapeutic interventions.However, it still challenge to identify, isolate quantify accurately, efficiently selectively.Further studies on will explore their potential translational medicine provide new avenues creation of effective clinical diagnostics strategies; use these applications be called exosome theranostics.This review describes fundamental formation uptake.In addition, roles biology also illustrated with focus how exploited engineered powerful tools medicine.

Language: Английский

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Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

Cancer Cell, Journal Year: 2016, Volume and Issue: 29(5), P. 653 - 668

Published: April 30, 2016

Language: Английский

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Exosomes: Therapy delivery tools and biomarkers of diseases

Pharmacology & Therapeutics, Journal Year: 2017, Volume and Issue: 174, P. 63 - 78

Published: Feb. 13, 2017

Language: Английский

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Lipids in exosomes: Current knowledge and the way forward

Progress in Lipid Research, Journal Year: 2017, Volume and Issue: 66, P. 30 - 41

Published: March 23, 2017

Lipids are essential components of exosomal membranes, and it is well-known that specific lipids enriched in exosomes compared to their parent cells. In this review we discuss current knowledge about the lipid composition exosomes. We compare published data for different classes exosomes, what known species, i.e. molecules with fatty acyl groups. Moreover, elaborate on hypothesis hand-shaking between very-long-chain sphingolipids outer leaflet PS 18:0/18:1 inner leaflet, propose be an important mechanism membrane biology, not only The similarity HIV particles, detergent resistant used as rafts models, also discussed. Furthermore, summarize role metabolizing enzymes formation release Finally, use biomarkers how may importance researchers aiming drug delivery vehicles conclusion, have summarized presently identified issues should taken into consideration future studies.

Language: Английский

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Cells release subpopulations of exosomes with distinct molecular and biological properties

Scientific Reports, Journal Year: 2016, Volume and Issue: 6(1)

Published: March 2, 2016

Abstract Cells release nano-sized membrane vesicles that are involved in intercellular communication by transferring biological information between cells. It is generally accepted cells at least three types of extracellular (EVs): apoptotic bodies, microvesicles and exosomes. While a wide range putative functions have been attributed to exosomes, they assumed represent homogenous population EVs. We hypothesized the existence subpopulations exosomes with defined molecular compositions properties. Density gradient centrifugation isolated revealed presence two distinct subpopulations, differing biophysical properties their proteomic RNA repertoires. Interestingly, mediated differential effects on gene expression programmes recipient In conclusion, we demonstrate exosome unique elicit Further dissection heterogeneity will advance our understanding exosomal biology health disease accelerate development exosome-based diagnostics therapeutics.

Language: Английский

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