International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
24(1), P. 12 - 12
Published: Dec. 20, 2022
Despite
the
remarkable
progress
in
cancer
treatment
up
to
now,
we
are
still
far
from
conquering
disease.
The
most
substantial
change
after
malignant
transformation
of
normal
cells
into
is
alteration
their
metabolism.
Cancer
reprogram
metabolism
support
elevated
energy
demand
as
well
acquisition
and
maintenance
malignancy,
even
nutrient-poor
environments.
metabolic
alterations,
under
aerobic
conditions,
such
upregulation
glucose
uptake
glycolysis
(the
Warburg
effect),
increase
ROS
(reactive
oxygen
species)
glutamine
dependence,
which
prominent
features
Among
these
high
dependency
has
attracted
serious
attention
research
community.
In
addition,
oncogenic
signaling
pathways
well-known
important
genetic
mutations
play
regulatory
roles,
either
directly
or
indirectly,
central
carbon
identification
convergent
phenotypes
crucial
targeting
cells.
this
review,
investigate
relationship
between
signal
transduction
pathways,
highlight
recent
developments
anti-cancer
therapy
that
target
Cancers,
Journal Year:
2022,
Volume and Issue:
14(23), P. 5896 - 5896
Published: Nov. 29, 2022
The
long-chain
fatty
acyl
CoA
synthetase
(ACSLs)
family
of
enzymes
contributes
significantly
to
lipid
metabolism
and
produces
acyl-coenzyme
A
by
catalyzing
acid
oxidation.
dysregulation
ACSL3
ACSL4,
which
belong
the
five
isoforms
ACSLs,
plays
a
key
role
in
cancer
initiation,
development,
metastasis,
tumor
immunity
may
provide
several
possible
therapeutic
strategies.
Moreover,
ACSL4
are
crucial
for
ferroptosis,
non-apoptotic
cell
death
triggered
accumulation
membrane
peroxides
due
iron
overload.
Here,
we
present
summary
current
knowledge
on
their
functions
various
cancers.
Research
molecular
mechanisms
involved
regulation
ferroptosis
is
critical
developing
targeted
therapies
cancer.
Experimental & Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
55(7), P. 1357 - 1370
Published: July 3, 2023
Abstract
Metabolic
reprogramming
and
epigenetic
modifications
are
hallmarks
of
cancer
cells.
In
cells,
metabolic
pathway
activity
varies
during
tumorigenesis
progression,
indicating
regulated
plasticity.
changes
often
closely
related
to
changes,
such
as
alterations
in
the
expression
or
epigenetically
modified
enzymes,
which
may
exert
a
direct
an
indirect
influence
on
cellular
metabolism.
Therefore,
exploring
mechanisms
underlying
regulating
tumor
cell
metabolism
is
important
for
further
understanding
pathogenesis.
Here,
we
mainly
focus
latest
studies
regulations,
including
glucose,
lipid
amino
acid
context,
then
emphasize
modifications.
Specifically,
discuss
role
played
by
DNA
methylation,
chromatin
remodeling,
noncoding
RNAs
histone
lactylation
growth
progression.
Finally,
summarize
prospects
potential
therapeutic
strategies
based
Cells,
Journal Year:
2022,
Volume and Issue:
11(8), P. 1367 - 1367
Published: April 17, 2022
Alzheimer's
Disease
(AD)
is
a
progressive
neurodegenerative
disease
characterized
by
amyloid-β
(Aβ)
plaque
deposition
and
neurofibrillary
tangle
accumulation
in
the
brain.
Although
several
studies
have
been
conducted
to
unravel
complex
interconnected
pathophysiology
of
AD,
clinical
trial
failure
rates
high,
no
disease-modifying
therapies
are
presently
available.
Fluid
biomarker
discovery
for
AD
rapidly
expanding
field
research
aimed
at
anticipating
diagnosis
following
progression
over
time.
Currently,
Aβ
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(22), P. 13968 - 13968
Published: Nov. 12, 2022
An
altered
metabolism
is
involved
in
the
development
of
clear
cell
renal
carcinoma
(ccRCC).
MUC1
overexpression
has
been
found
to
be
associated
with
advanced
disease
and
poor
prognosis.
In
this
study,
we
evaluated
metabolomic
profile
human
ccRCC,
according
expression,
integrated
it
transcriptomic
data.
Moreover,
analyzed
role
sustaining
ccRCC
aggressiveness
prognostic
value
its
soluble
form
CA15-3.
Integrated
analysis
showed
that
MUC1-expressing
was
characterized
by
metabolic
reprogramming
involving
glucose
lipid
pathway.
addition,
primary
cancer
cells
treated
a
small
interfering
RNA
targeting
(siMUC1)
migrated
proliferated
at
slower
rate
than
untreated
cells.
After
cisplatin
treatment,
death
siMUC1
significantly
greater
Kaplan–Meier
curves
significant
differences
CSS
PFS
among
groups
patients
high
versus
low
levels
multivariate
analysis,
CA15-3
an
independent
adverse
factor
for
cancer-specific
progression-free
survival.
conclusion,
expressing
particular
reprogramming.
The
inhibition
expression
decreases
motility
viability
improves
susceptibility,
suggesting
pathway
can
regulate
de
novo
chemotherapy
resistance
ccRCC.
Theranostics,
Journal Year:
2023,
Volume and Issue:
13(6), P. 1774 - 1808
Published: Jan. 1, 2023
Metabolic
reprogramming
is
one
of
the
most
important
hallmarks
malignant
tumors.Specifically,
lipid
metabolic
has
marked
impacts
on
cancer
progression
and
therapeutic
response
by
remodeling
tumor
microenvironment
(TME).In
past
few
decades,
immunotherapy
revolutionized
treatment
landscape
for
advanced
cancers.Lipid
plays
pivotal
role
in
regulating
immune
to
immunotherapy.Here,
we
systematically
reviewed
characteristics,
mechanism,
cells
TME,
appraised
effects
various
cell
death
modes
(specifically
ferroptosis)
metabolism,
summarized
antitumor
therapies
targeting
metabolism.Overall,
profound
microenvironment;
therefore,
may
lead
development
innovative
clinical
applications
including
sensitizing
immunotherapy.
