RNA,
Journal Year:
2018,
Volume and Issue:
25(1), P. 1 - 16
Published: Oct. 17, 2018
MicroRNAs
(miRNAs)
are
important
regulators
of
gene
expression
that
bind
complementary
target
mRNAs
and
repress
their
expression.
Precursor
miRNA
molecules
undergo
nuclear
cytoplasmic
processing
events,
carried
out
by
the
endoribonucleases
DROSHA
DICER,
respectively,
to
produce
mature
miRNAs
loaded
onto
RISC
(RNA-induced
silencing
complex)
exert
biological
function.
Regulation
levels
is
critical
in
development,
differentiation,
disease,
as
demonstrated
multiple
control
during
biogenesis
cascade.
Here,
we
will
focus
on
post-transcriptional
mechanisms
discuss
impact
cis
-acting
sequences
precursor
miRNAs,
well
trans
factors
these
precursors
influence
processing.
In
particular,
highlight
role
general
RNA-binding
proteins
(RBPs)
specific
revealing
a
complex
layer
regulation
production
Frontiers in Endocrinology,
Journal Year:
2018,
Volume and Issue:
9
Published: Aug. 3, 2018
MicroRNAs
(miRNAs)
are
a
class
of
non-coding
RNAs
that
play
important
roles
in
regulating
gene
expression.
The
majority
miRNAs
transcribed
from
genes
into
primary
and
processed
precursor
finally
mature
miRNAs.
In
most
cases,
interact
with
the
3'
UTR
target
mRNAs
to
induce
mRNA
degradation
translational
repression.
However,
interaction
other
regions,
including
5'
UTR,
coding
sequence,
promoters,
have
also
been
reported.
Under
certain
conditions,
can
activate
translation
or
regulate
transcription.
their
is
dynamic
dependent
on
many
factors,
such
as
subcellular
location
miRNAs,
abundancy
mRNAs,
affinity
miRNA-mRNA
interactions.
be
secreted
extracellular
fluids
transported
cells
via
vesicles,
exosomes,
by
binding
proteins,
Argonautes.
Extracellular
function
chemical
messengers
mediate
cell-cell
communication.
this
review,
we
provide
an
update
canonical
non-canonical
miRNA
biogenesis
pathways
various
mechanisms
underlying
miRNA-mediated
regulations.
We
summarize
current
knowledge
dynamics
action
secretion,
transfer,
uptake
Physiological Reviews,
Journal Year:
2016,
Volume and Issue:
96(4), P. 1297 - 1325
Published: Aug. 18, 2016
Advances
in
RNA-sequencing
techniques
have
led
to
the
discovery
of
thousands
non-coding
transcripts
with
unknown
function.
There
are
several
types
linear
RNAs
such
as
microRNAs
(miRNA)
and
long
(lncRNA),
well
circular
(circRNA)
consisting
a
closed
continuous
loop.
This
review
guides
reader
through
important
aspects
RNA
biology.
includes
their
biogenesis,
mode
actions,
physiological
function,
role
disease
context
(such
cancer
or
cardiovascular
system).
We
specifically
focus
on
potential
therapeutic
targets
diagnostic
biomarkers.
Journal of Cellular Physiology,
Journal Year:
2018,
Volume and Issue:
234(5), P. 5451 - 5465
Published: Nov. 23, 2018
Abstract
MicroRNAs
(miRNAs)
are
a
class
of
small
noncoding
RNAs,
which
function
in
posttranscriptional
regulation
gene
expression.
They
powerful
regulators
various
cellular
activities
including
cell
growth,
differentiation,
development,
and
apoptosis.
have
been
linked
to
many
diseases,
currently
miRNA‐mediated
clinical
trial
has
shown
promising
results
for
treatment
cancer
viral
infection.
This
review
provides
an
overview
update
on
miRNAs
biogenesis,
expression,
their
biological
functions,
role
epigenetics
cell–cell
communication.
In
addition,
alteration
following
exercise,
association
with
therapeutic
potential
will
be
explained.
Finally,
miRNA
bioinformatics
tools
conventional
methods
detection
quantification
discussed.
