Steps in Mechanotransduction Pathways that Control Cell Morphology DOI Open Access
Haguy Wolfenson, Bo Yang, Michael P. Sheetz

et al.

Annual Review of Physiology, Journal Year: 2018, Volume and Issue: 81(1), P. 585 - 605

Published: Nov. 7, 2018

It is increasingly clear that mechanotransduction pathways play important roles in regulating fundamental cellular functions. Of the basic mechanical functions, determination of morphology critical. Cells typically use many mechanosensitive steps and different cell states to achieve a polarized shape through repeated testing microenvironment. Indeed, determined by microenvironment periodic activation motility, mechanotesting, mechanoresponse functions hormones, internal clocks, receptor tyrosine kinases. Patterned substrates controlled environments with defined rigidities limit range behavior influence state decisions are thus very useful for studying these steps. The recently rigidity sensing process provides good example how cells repeatedly test their also linked cancer. In general, aberrant extracellular matrix mechanosensing associated numerous conditions, including cardiovascular disease, aging, fibrosis, correlate changes tissue composition. Hence, detailed descriptions involved responding needed better understand both mechanisms homeostasis pathomechanisms human disease.

Language: Английский

Electroactive Biomaterials and Systems for Cell Fate Determination and Tissue Regeneration: Design and Applications DOI
Zhirong Liu,

Xingyi Wan,

Zhong Lin Wang

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(32)

Published: June 12, 2021

Abstract During natural tissue regeneration, microenvironment and stem cell niche including cell–cell interaction, soluble factors, extracellular matrix (ECM) provide a train of biochemical biophysical cues for modulation behaviors functions. Design functional biomaterials to mimic the tissue/cell have great potentials regeneration applications. Recently, electroactive drawn increasing attentions not only as scaffolds adhesion structural support, but also modulators regulate cell/tissue function, especially electrically excitable cells tissues. More importantly, electrostimulation can further modulate myriad biological processes, from cycle, migration, proliferation differentiation neural conduction, muscle contraction, embryogenesis, regeneration. In this review, endogenous bioelectricity piezoelectricity are introduced. Then, design rationale is discussed imitating dynamic microenvironment, well their mediated applying pathways. Recent advances in systematically overviewed fate mainly nerve bone engineering, cardiac engineering. Finally, significance simulating native emphasized open challenges future perspectives concluded.

Language: Английский

Citations

326
Crosstalk between mechanotransduction and metabolism DOI
Patrizia Romani, Lorea Valcárcel-Jiménez, Christian Frezza

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(1), P. 22 - 38

Published: Nov. 13, 2020

Language: Английский

Citations

299
Piezoelectric nanogenerators for personalized healthcare DOI
Weili Deng, Yihao Zhou, Alberto Libanori

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(9), P. 3380 - 3435

Published: Jan. 1, 2022

Piezoelectric nanogenerators are becoming a compelling bioelectronics platform technology for human-associated energy harvesting, self-powered sensing, and therapeutics, which will largely contribute to the medical field in era of Internet things.

Language: Английский

Citations

295
Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics DOI Creative Commons
Alejandro Carnicer‐Lombarte, Shao‐Tuan Chen, George G. Malliaras

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2021, Volume and Issue: 9

Published: April 15, 2021

The implantation of any foreign material into the body leads to development an inflammatory and fibrotic process-the reaction (FBR). Upon a tissue, cells immune system become attracted attempt degrade it. If this degradation fails, fibroblasts envelop form physical barrier isolate it from rest body. Long-term medical devices faces great challenge presented by FBR, as cellular response disrupts interface between implant its target tissue. This is particularly true for nerve neuroprosthetic implants-devices implanted nerves address conditions such sensory loss, muscle paralysis, chronic pain, epilepsy. Nerve neuroprosthetics rely on tight interfacing tissue electrodes detect tiny electrical signals carried axons, and/or electrically stimulate small subsets axons within nerve. Moreover, advances in microfabrication drive field increasingly miniaturized implants, need stable, intimate implant-tissue likely quickly limiting factor new technologies. Here, we provide overview material-cell interactions leading FBR. We review current technologies (cuff, penetrating, regenerative interfaces) how long-term function these limited Finally, discuss properties (such stiffness size), pharmacological therapies, or use biodegradable materials may be exploited minimize FBR implants improve their stability.

Language: Английский

Citations

285
YAP/TAZ functions and their regulation at a glance DOI Open Access
Arianna Pocaterra, Patrizia Romani, Sirio Dupont

et al.

Journal of Cell Science, Journal Year: 2020, Volume and Issue: 133(2)

Published: Jan. 15, 2020

ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous genes, which shuttle between the cytoplasm nucleus in response to multiple inputs, including Hippo pathway. In nucleus, they pair with DNA-binding factors of TEAD family regulate gene expression. Nuclear YAP/TAZ promote cell proliferation, organ overgrowth, survival stress dedifferentiation post-mitotic cells into their respective tissue progenitors. required for growth embryonic tissues, wound healing regeneration, where activated cell-intrinsic extrinsic cues. Surprisingly, this activity is dispensable many adult self-renewing constantly kept check. lay at center a complex regulatory network cell-autonomous but also cell- tissue-level structural features such as mechanical properties microenvironment, establishment cell–cell junctions basolateral polarity. Enhanced levels observed cancers, sustain tumor growth, drug resistance malignancy. Cell Science Glance article accompanying poster, we review biological functions mechanisms, highlight position signaling network.

Language: Английский

Citations

283
Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise DOI Open Access
Henning Wackerhage, Brad J. Schöenfeld, D. Lee Hamilton

et al.

Journal of Applied Physiology, Journal Year: 2018, Volume and Issue: 126(1), P. 30 - 43

Published: Oct. 18, 2018

One of the most striking adaptations to exercise is skeletal muscle hypertrophy that occurs in response resistance exercise. A large body work shows a mammalian target rapamycin complex 1 (mTORC1)-mediated increase protein synthesis key, but not sole, mechanism by which causes hypertrophy. While much signaling cascade has been identified, initiating, exercise-induced and hypertrophy-stimulating stimuli have remained elusive. For purpose this review, we define an signal as "hypertrophy stimulus," sensor such sensor." In review discuss our current knowledge specific mechanical stimuli, damage/injury-associated metabolic stress-associated triggers, potential stimuli. Mechanical signals are prime candidates, filamin-C-BAG3-dependent regulation mTORC1, Hippo, autophagy plausible albeit still incompletely characterized sensor. Other candidate mechanosensing mechanisms nuclear deformation-initiated or several related costameres, functional equivalents focal adhesions other cells. damage probably essential for hypertrophy, it unclear whether how could augment hypertrophic response. Interventions combine blood flow restriction especially low load suggest exercise-regulated metabolites be based on indirect evidence metabolite candidates poorly characterized.

Language: Английский

Citations

269
Substrate curvature as a cue to guide spatiotemporal cell and tissue organization DOI Creative Commons
Sebastien J. P. Callens,

Rafael J.C. Uyttendaele,

Lidy E. Fratila‐Apachitei

et al.

Biomaterials, Journal Year: 2019, Volume and Issue: 232, P. 119739 - 119739

Published: Dec. 27, 2019

Recent evidence clearly shows that cells respond to various physical cues in their environments, guiding many cellular processes and tissue morphogenesis, pathology, repair. One aspect is gaining significant traction the role of local geometry as an extracellular cue. Elucidating how affects cell behavior is, indeed, crucial design artificial scaffolds understand growth remodeling. Perhaps most fundamental descriptor surface curvature, a growing body confirms curvature spatiotemporal organization tissues. While well-defined differential geometry, remains somewhat ambiguously treated biological studies. Here, we provide more formal framework, based on notions mean Gaussian summarize available guidance at levels. We discuss involved mechanisms, highlighting interplay between tensile forces substrate forms foundation guidance. Moreover, show relatively simple computational models, some application flow, are able capture experimental remarkably well. Since principles could be leveraged for regeneration, implications geometrical scaffold also discussed. Finally, perspectives future research opportunities provided.

Language: Английский

Citations

269
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions DOI
Pakorn Kanchanawong, David Calderwood

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 24(2), P. 142 - 161

Published: Sept. 27, 2022

Language: Английский

Citations

262
Biological responses to physicochemical properties of biomaterial surface DOI Creative Commons
Maryam Rahmati, Eduardo A. Silva, Janne E. Reseland

et al.

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(15), P. 5178 - 5224

Published: Jan. 1, 2020

Biomedical scientists use chemistry-driven processes found in nature as an inspiration to design biomaterials promising diagnostic tools, therapeutic solutions, or tissue substitutes.

Language: Английский

Citations

256
Simulating tissue mechanics with agent-based models: concepts, perspectives and some novel results DOI Open Access
Paul Van Liedekerke, Margriet M. Palm,

Nick Jagiella

et al.

Computational Particle Mechanics, Journal Year: 2015, Volume and Issue: 2(4), P. 401 - 444

Published: Nov. 26, 2015

Language: Английский

Citations

251