Nanotools for Neuroscience and Brain Activity Mapping DOI
A. Paul Alivisatos, Anne M. Andrews,

Edward S. Boyden

et al.

ACS Nano, Journal Year: 2013, Volume and Issue: 7(3), P. 1850 - 1866

Published: March 20, 2013

Neuroscience is at a crossroads. Great effort being invested into deciphering specific neural interactions and circuits. At the same time, there exist few general theories or principles that explain brain function. We attribute this disparity, in part, to limitations current methodologies. Traditional neurophysiological approaches record activities of one neuron neurons time. Neurochemical focus on single neurotransmitters. Yet, an increasing realization circuits operate emergent levels, where between hundreds thousands neurons, utilizing multiple chemical transmitters, generate functional states. Brains function nanoscale, so tools study brains must ultimately scale, as well. Nanoscience nanotechnology are poised provide rich toolkit novel methods explore by enabling simultaneous measurement manipulation activity even millions neurons. others refer goal Brain Activity Mapping Project. In Nano Focus, we discuss how recent developments nanoscale analysis design synthesis nanomaterials have generated optical, electrical, can readily be adapted for use neuroscience. These represent exciting areas technical development research. Moreover, unique opportunities nanoscientists, nanotechnologists, other physical scientists engineers contribute tackling challenging problems involved understanding fundamentals

Language: Английский

Neuronal circuits for fear and anxiety DOI
Philip Tovote, Jonathan P. Fadok, Andreas Lüthi

et al.

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(6), P. 317 - 331

Published: May 20, 2015

Language: Английский

Citations

1616

Ventromedial hypothalamic neurons control a defensive emotion state DOI Creative Commons

Prabhat S. Kunwar,

Moriel Zelikowsky, Ryan Remedios

et al.

eLife, Journal Year: 2015, Volume and Issue: 4

Published: March 6, 2015

Defensive behaviors reflect underlying emotion states, such as fear. The hypothalamus plays a role in behaviors, but prevailing textbook views depict it an effector of upstream centers, the amygdala, rather than center itself. We used optogenetic manipulations to probe function specific hypothalamic cell type that mediates innate defensive responses. These neurons are sufficient drive multiple actions, and required for diverse contexts. behavioral consequences activating these neurons, moreover, exhibit properties characteristic states general, including scalability, (negative) valence, generalization persistence. Importantly, can also condition learned behavior, further refuting long-standing claims is unable support emotional learning therefore not center. data indicate integral instantiate simply passive centers.

Language: Английский

Citations

1083

Dopamine neurons modulate neural encoding and expression of depression-related behaviour DOI
Kay M. Tye,

Julie J. Mirzabekov,

Melissa R. Warden

et al.

Nature, Journal Year: 2012, Volume and Issue: 493(7433), P. 537 - 541

Published: Dec. 11, 2012

Language: Английский

Citations

993

Modelling and analysis of local field potentials for studying the function of cortical circuits DOI
Gaute T. Einevoll, Christoph Kayser, Nikos K. Logothetis

et al.

Nature reviews. Neuroscience, Journal Year: 2013, Volume and Issue: 14(11), P. 770 - 785

Published: Oct. 18, 2013

Language: Английский

Citations

819

Reward and aversion in a heterogeneous midbrain dopamine system DOI
Stephan Lammel, Byung Kook Lim, Robert C. Malenka

et al.

Neuropharmacology, Journal Year: 2013, Volume and Issue: 76, P. 351 - 359

Published: April 8, 2013

Language: Английский

Citations

743

Treatment of bipolar disorder DOI
John Geddes, David J. Miklowitz

The Lancet, Journal Year: 2013, Volume and Issue: 381(9878), P. 1672 - 1682

Published: May 1, 2013

Language: Английский

Citations

731

Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens DOI Creative Commons
Jonathan P. Britt,

Faïza Benaliouad,

Ross A. McDevitt

et al.

Neuron, Journal Year: 2012, Volume and Issue: 76(4), P. 790 - 803

Published: Nov. 1, 2012

Language: Английский

Citations

684

Resolving the neural circuits of anxiety DOI
Gwendolyn G. Calhoon, Kay M. Tye

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 18(10), P. 1394 - 1404

Published: Sept. 25, 2015

Language: Английский

Citations

667

Dopamine System Dysregulation in Major Depressive Disorders DOI Creative Commons
Pauline Belujon, Anthony A. Grace

The International Journal of Neuropsychopharmacology, Journal Year: 2017, Volume and Issue: 20(12), P. 1036 - 1046

Published: June 28, 2017

Anhedonia is considered a core feature of major depressive disorder, and the dopamine system plays pivotal role in hedonic deficits described this disorder. Dopaminergic activity complex under regulation multiple brain structures, including ventral subiculum hippocampus basolateral amygdala. Whereas basic clinical studies demonstrate dopaminergic depression, origin these likely lies dysregulation its regulatory afferent circuits. This review explores current information regarding modulation relevance to as well some system-level effects novel antidepressants such agomelatine ketamine.

Language: Английский

Citations

609

Labelling and optical erasure of synaptic memory traces in the motor cortex DOI
Akiko Hayashi‐Takagi, Sho Yagishita,

Mayumi Nakamura

et al.

Nature, Journal Year: 2015, Volume and Issue: 525(7569), P. 333 - 338

Published: Sept. 1, 2015

Language: Английский

Citations

607