Molecular Cancer,
Journal Year:
2021,
Volume and Issue:
20(1)
Published: Jan. 4, 2021
Abstract
Esophageal
cancer
(EC)
is
a
disease
often
marked
by
aggressive
growth
and
poor
prognosis.
Lack
of
targeted
therapies,
resistance
to
chemoradiation
therapy,
distant
metastases
among
patients
with
advanced
account
for
the
high
mortality
rate.
The
tumor
microenvironment
(TME)
contains
several
cell
types,
including
fibroblasts,
immune
cells,
adipocytes,
stromal
proteins,
factors,
which
play
significant
role
in
supporting
behavior
cells.
complex
dynamic
interactions
secreted
cytokines,
chemokines,
their
receptors
mediate
chronic
inflammation
immunosuppressive
TME
favoring
progression,
metastasis,
decreased
response
therapy.
molecular
changes
are
used
as
biological
markers
diagnosis,
prognosis,
treatment
patients.
This
review
highlighted
novel
insights
into
understanding
functional
impact
deregulated
cytokines
chemokines
imparting
EC,
stressing
nature
therapeutic
consequences
cytokine-chemokine
network.
We
also
discuss
oncogenic
potential
contributing
Epithelial-Mesenchymal
Transition
(EMT),
angiogenesis,
immunosuppression,
metastatic
niche,
development.
In
addition,
it
discusses
wide
range
intracellular
signaling
pathways
that
occur
TME.
Overall,
this
relatively
unexplored
field
could
provide
crucial
immunology
encourage
effective
application
modulatory
therapy
EC.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(3), P. 879 - 920
Published: Jan. 1, 2023
This
tutorial
review
provides
a
general
overview
for
the
design
of
prodrugs
and
activatable
phototherapeutics
which
enables
development
improved
therapies.
Cancers,
Journal Year:
2020,
Volume and Issue:
12(6), P. 1498 - 1498
Published: June 8, 2020
Metastasis
represents
a
serious
complication
in
the
treatment
of
cancer.
Flavonoids
are
plant
secondary
metabolites
exerting
various
health
beneficiary
effects.
The
effects
flavonoids
against
cancer
associated
not
only
with
early
stages
process,
but
also
progression
and
spread
into
distant
sites.
showed
potent
anti-cancer
models
vitro
vivo,
mediated
via
regulation
key
signaling
pathways
involved
migration
invasion
cells
metastatic
progression,
including
regulators
epithelial-mesenchymal
transition
or
regulatory
molecules
such
as
MMPs,
uPA/uPAR,
TGF-β
other
contributors
complex
process
spread.
Moreover,
modulated
expression
genes
improved
inflammatory
status,
part
development
metastasis.
documented
clear
potential
to
improve
effectiveness
conventional
chemotherapeutic
agents.
Most
importantly,
represent
environmentally-friendly
cost-effective
substances;
moreover,
wide
spectrum
different
demonstrated
safety
minimal
side
during
long-termed
administration.
In
addition,
bioavailability
can
be
by
their
conjugation
metal
ions
structural
modifications
radiation.
conclusion,
flavonoids,
targeting
all
phases
carcinogenesis
should
implemented
clinical
research
order
strengthen
use
future
targeted
prevention
therapy
high-risk
individuals
patients
aggressive
disease
potential.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: May 20, 2024
Abstract
Tumor
biomarkers,
the
substances
which
are
produced
by
tumors
or
body’s
responses
to
during
tumorigenesis
and
progression,
have
been
demonstrated
possess
critical
encouraging
value
in
screening
early
diagnosis,
prognosis
prediction,
recurrence
detection,
therapeutic
efficacy
monitoring
of
cancers.
Over
past
decades,
continuous
progress
has
made
exploring
discovering
novel,
sensitive,
specific,
accurate
tumor
significantly
promoted
personalized
medicine
improved
outcomes
cancer
patients,
especially
advances
molecular
biology
technologies
developed
for
detection
biomarkers.
Herein,
we
summarize
discovery
development
including
history
conventional
innovative
used
biomarker
classification
biomarkers
based
on
tissue
origins,
application
clinical
management.
In
particular,
highlight
recent
advancements
biomarker-based
anticancer-targeted
therapies
emerging
as
breakthroughs
promising
strategies.
We
also
discuss
limitations
challenges
that
need
be
addressed
provide
insights
perspectives
turn
into
opportunities
this
field.
Collectively,
multiple
emphasized
review
may
guidance
precision
medicine,
broaden
horizons
future
research
directions,
expedite
patients
according
their
rather
than
organs
origin.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: Jan. 11, 2021
Abstract
Epigenetic
alterations
play
an
important
role
in
tumor
progression
of
diffuse
large
B-cell
lymphoma
(DLBCL).
However,
the
biological
relevance
epigenetic
gene
mutations
on
microenvironment
remains
to
be
determined.
The
core
set
genes
relating
histone
methylation
(
KMT2D
,
KMT2C
EZH2
),
acetylation
CREBBP
EP300
DNA
TET2
and
chromatin
remodeling
ARID1A
)
were
detected
training
cohort
316
patients
by
whole-genome/exome
sequencing
(WGS/WES)
validation
303
with
newly
diagnosed
DLBCL
targeted
sequencing.
Their
correlation
peripheral
blood
immune
cells
clinical
outcomes
assessed.
Underlying
mechanisms
investigated
both
vitro
vivo.
Among
all
619
patients,
somatic
(19.5%)
most
frequently
observed,
followed
(8.7%),
(8.4%),
(8.2%),
(7.8%),
(6.8%),
(2.9%).
them,
/
significantly
associated
decreased
absolute
lymphocyte-to-monocyte
ratios,
as
well
inferior
progression-free
overall
survival.
In
B-lymphoma
cells,
mutation
or
knockdown
inhibited
H3K27
acetylation,
downregulated
FBXW7
expression,
activated
NOTCH
pathway,
downstream
CCL2/CSF1
resulting
tumor-associated
macrophage
polarization
M2
phenotype
cell
proliferation.
murine
models,
xenografted
tumors
bearing
presented
lower
higher
recruitment,
more
rapid
growth
than
those
wild-type
control
via
FBXW7-NOTCH-CCL2/CSF1
axis.
Our
work
thus
contributed
understanding
aberrant
regulation
alternative
mechanism
DLBCL.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(5), P. 2699 - 2804
Published: Feb. 29, 2024
The
ability
to
gain
spatiotemporal
information,
and
in
some
cases
achieve
control,
the
context
of
drug
delivery
makes
theranostic
fluorescent
probes
an
attractive
intensely
investigated
research
topic.
This
interest
is
reflected
steep
rise
publications
on
topic
that
have
appeared
over
past
decade.
Theranostic
probes,
their
various
incarnations,
generally
comprise
a
fluorophore
linked
masked
drug,
which
released
as
result
certain
stimuli,
with
both
intrinsic
extrinsic
stimuli
being
reported.
release
then
signaled
by
emergence
signal.
Importantly,
use
appropriate
fluorophores
has
enabled
not
only
this
emerging
fluorescence
marker
for
but
also
provided
modalities
useful
photodynamic,
photothermal,
sonodynamic
therapeutic
applications.
In
review
we
highlight
recent
work
particular
focus
are
activated
tumor
microenvironments.
We
summarize
efforts
develop
other
applications,
such
neurodegenerative
diseases
antibacterials.
celebrates
diversity
designs
reported
date,
from
discrete
small-molecule
systems
nanomaterials.
Our
aim
provide
insights
into
potential
clinical
impact
still-emerging
direction.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(8), P. 2594 - 2594
Published: July 28, 2021
Propolis
is
a
natural
material
that
honey
bees
(Apis mellifera)
produce
from
various
botanical
sources.
The
therapeutic
activity
of
propolis,
including
antibacterial,
antifungal,
and
anti-inflammatory
effects,
have
been
known
since
antiquity.
Cancer
one
the
major
burdens
disease
worldwide,
therefore,
numerous
studies
are
being
conducted
to
develop
new
chemotherapeutic
agents
treatments
for
cancer.
rich
source
biologically
active
compounds,
which
affect
signaling
pathways
regulating
crucial
cellular
processes.
results
latest
research
show
propolis
can
inhibit
proliferation,
angiogenesis,
metastasis
cancer
cells
stimulate
apoptosis.
Moreover,
it
may
influence
tumor
microenvironment
multidrug
resistance
cancers.
This
review
briefly
summarizes
molecular
mechanisms
anticancer
its
compounds
highlights
potential
benefits
reduce
side
effects
chemotherapy
radiotherapy.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 1, 2024
Abstract
Combining
existing
drug
therapy
is
essential
in
developing
new
therapeutic
agents
disease
prevention
and
treatment.
In
preclinical
investigations,
combined
effect
of
certain
known
drugs
has
been
well
established
treating
extensive
human
diseases.
Attributed
to
synergistic
effects
by
targeting
various
pathways
advantages,
such
as
reduced
administration
dose,
decreased
toxicity,
alleviated
resistance,
combinatorial
treatment
now
being
pursued
delivering
combat
major
clinical
illnesses,
cancer,
atherosclerosis,
pulmonary
hypertension,
myocarditis,
rheumatoid
arthritis,
inflammatory
bowel
disease,
metabolic
disorders
neurodegenerative
Combinatorial
involves
combining
or
co-delivering
two
more
for
a
specific
disease.
Nanoparticle
(NP)-mediated
delivery
systems,
i.e.,
liposomal
NPs,
polymeric
NPs
nanocrystals,
are
great
interest
wide
range
due
targeted
delivery,
extended
release,
higher
stability
avoid
rapid
clearance
at
infected
areas.
This
review
summarizes
targets
diseases,
clinically
approved
combinations
the
development
multifunctional
emphasizes
strategies
based
on
severe
Ultimately,
we
discuss
challenging
NP-codelivery
translation
provide
potential
approaches
address
limitations.
offers
comprehensive
overview
recent
cutting-edge
NP-mediated
combination
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(21), P. 11306 - 11306
Published: Oct. 20, 2021
Cancer
is
a
condition
caused
by
many
mechanisms
(genetic,
immune,
oxidation,
and
inflammatory).
Anticancer
therapy
aims
to
destroy
or
stop
the
growth
of
cancer
cells.
Resistance
treatment
theleading
cause
inefficiency
current
standard
therapies.
Targeted
therapies
are
most
effective
due
low
number
side
effects
resistance.
Among
small
molecule
natural
compounds,
flavonoids
particular
interest
for
theidentification
new
anticancer
agents.
Chalcones
precursors
all
have
biological
activities.
The
activity
chalcones
ability
these
compounds
act
on
targets.
Natural
chalcones,
such
as
licochalcones,
xanthohumol
(XN),
panduretin
(PA),
loncocarpine,
been
extensively
studied
modulated.
Modification
basic
structure
in
order
obtain
with
superior
cytotoxic
properties
has
performed
modulating
aromatic
residues,
replacing
residues
heterocycles,
obtaining
hybrid
molecules.
A
huge
chalcone
derivatives
diaryl
ether,
sulfonamide,
amine
obtained,
their
presence
being
favorable
activity.
amino
group
aminochalconesis
always
antitumor
This
why
molecules
different
nitrogen
hetercycles
obtained.
From
these,
azoles
(imidazole,
oxazoles,
tetrazoles,
thiazoles,
1,2,3-triazoles,
1,2,4-triazoles)
importance
identification
