Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: Roles and mechanisms

Water Research, Journal Year: 2022, Volume and Issue: 224, P. 119060 - 119060

Published: Sept. 6, 2022

Language: Английский

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Effects and relevant mechanisms of non-antibiotic factors on the horizontal transfer of antibiotic resistance genes in water environments: A review

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 806, P. 150568 - 150568

Published: Sept. 24, 2021

Language: Английский

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The effects of biochar on antibiotic resistance genes (ARGs) removal during different environmental governance processes: A review

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 435, P. 129067 - 129067

Published: May 4, 2022

Language: Английский

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Detection and various environmental factors of antibiotic resistance gene horizontal transfer

Environmental Research, Journal Year: 2022, Volume and Issue: 212, P. 113267 - 113267

Published: April 9, 2022

Language: Английский

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COVID-19 drugs in aquatic systems: a review

Environmental Chemistry Letters, Journal Year: 2022, Volume and Issue: 20(2), P. 1275 - 1294

Published: Jan. 15, 2022

Language: Английский

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Different microplastics distinctively enriched the antibiotic resistance genes in anaerobic sludge digestion through shifting specific hosts and promoting horizontal gene flow

Water Research, Journal Year: 2022, Volume and Issue: 228, P. 119356 - 119356

Published: Nov. 13, 2022

Language: Английский

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Antidepressants can induce mutation and enhance persistence toward multiple antibiotics

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(5)

Published: Jan. 23, 2023

Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in large quantities, with a similar pharmaceutical market share (4.8%) antibiotics (5%). While acknowledged as the major driver of increasing antibiotic resistance, little attention paid contribution antidepressants this process. Here, we demonstrate that at clinically relevant concentrations induce multiple antibiotics, even following short periods exposure. persistence was also enhanced. Phenotypic and genotypic analyses revealed enhanced production reactive oxygen species exposure directly associated increased resistance. An stress signature response stimulation efflux pump expression were persistence. Mathematical modeling predicted would accelerate emergence antibiotic-resistant bacteria, persister cells help maintain Overall, our findings highlight risk caused by antidepressants.

Language: Английский

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Fungicide exposure accelerated horizontal transfer of antibiotic resistance genes via plasmid-mediated conjugation

Water Research, Journal Year: 2023, Volume and Issue: 233, P. 119789 - 119789

Published: Feb. 23, 2023

Language: Английский

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Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens

The ISME Journal, Journal Year: 2024, Volume and Issue: 18(1)

Published: Jan. 1, 2024

Abstract Antimicrobial resistance is a major threat for public health. Plasmids play critical role in the spread of antimicrobial via horizontal gene transfer between bacterial species. However, it remains unclear how plasmids originally recruit and assemble various antibiotic genes (ARGs). Here, we track ARG recruitment assembly clinically relevant by combining systematic analysis 2420 complete plasmid genomes experimental validation. Results showed that across prevalent, 87% ARGs were observed to potentially among 8229 plasmid-borne ARGs. Interestingly, occur mostly compatible within same cell, with over 88% transfers occurring plasmids. Integron insertion sequences drive ongoing acquisition plasmids, especially which IS26 facilitates 63.1% events In vitro experiment validated important involved transferring gentamicin aacC1 Network four beta-lactam (blaTEM-1, blaNDM-4, blaKPC-2, blaSHV-1) shuffling 1029 45 clinical pathogens, suggesting alarming transferred accelerate propagation pathogens. are also able transmit environmental boundaries, terms high-sequence similarities This study demonstrated inter-plasmid universal mechanism ARGs, thus advancing our understanding emergence multidrug-resistant

Language: Английский

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Phthalate Esters Released from Plastics Promote Biofilm Formation and Chlorine Resistance

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(2), P. 1081 - 1090

Published: Jan. 7, 2022

Phthalate esters (PAEs) are commonly released from plastic pipes in some water distribution systems. Here, we show that exposure to a low concentration (1-10 μg/L) of three PAEs (dimethyl phthalate (DMP), di-n-hexyl (DnHP), and di-(2-ethylhexyl) (DEHP)) promotes Pseudomonas biofilm formation resistance free chlorine. At PAE concentrations ranging 1 5 μg/L, genes coding for quorum sensing, extracellular polymeric substances excretion, oxidative stress were upregulated by 2.7- 16.8-fold, 2.1- 18.9-fold, 1.6- 9.9-fold, respectively. Accordingly, more matrix was produced the polysaccharide eDNA contents increased 30.3-82.3 10.3-39.3%, respectively, relative unexposed controls. Confocal laser scanning microscopy showed stimulated densification (volumetric fraction 27.1 38.0-50.6%), which would hinder disinfectant diffusion. Biofilm verified atomic force microscopy, measured an increase elastic modulus 2.0- 3.2-fold. also antioxidative system, with cell-normalized superoxide dismutase, catalase, glutathione activities increasing 1.8- 3.0-fold, 1.0- 2.0-fold, 1.2- 1.6-fold, This likely protected cells against damage Overall, demonstrate environmentally relevant levels can upregulate molecular processes physiologic changes promote system expression, enhance disinfectants.

Language: Английский

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