International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114490 - 114490
Published: March 31, 2025
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 23, 2024
The damage to the central nervous system and dysfunction of body caused by spinal cord injury (SCI) are extremely severe. pathological process SCI is accompanied inflammation nerve cells. Current evidence suggests that oxidative stress, resulting from an increase in production reactive oxygen species (ROS) imbalance its clearance, plays a significant role secondary during SCI. transcription factor nuclear erythroid 2-related 2 (Nrf2) crucial regulatory molecule for cellular redox. This review summarizes recent advancements regulation ROS-Nrf2 signaling focuses on interaction between ROS different modes neuronal cell death after SCI, such as apoptosis, autophagy, pyroptosis, ferroptosis. Furthermore, we highlight pathways through which materials science, including exosomes, hydrogels, nanomaterials, can alleviate modulating clearance. provides valuable insights directions reducing alleviating stress.
Language: Английский
Citations
34
Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(2)
Published: Feb. 20, 2024
Abstract Traumatic brain injury (TBI) is a common trauma with high mortality and disability rates worldwide. However, the current management of this disease still unsatisfactory. Therefore, it necessary to investigate pathophysiological mechanisms TBI in depth improve treatment options. In recent decades, abundant evidence has highlighted significance endoplasmic reticulum stress (ERS) advancing central nervous system (CNS) disorders, including TBI. ERS following leads accumulation unfolded proteins, initiating protein response (UPR). Protein kinase RNA-like ER (PERK), inositol-requiring 1 (IRE1), activating transcription factor 6 (ATF6) are three major pathways UPR initiation that determine whether cell survives or dies. This review focuses on dual effects discusses underlying mechanisms. It suggested may crosstalk series molecular cascade responses, such as mitochondrial dysfunction, oxidative stress, neuroinflammation, autophagy, death, thus involved progression secondary after Hence, promising candidate for
Language: Английский
Citations
32
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: May 18, 2024
Abstract Substantial progress in research on sperm cryopreservation has occurred since the twentieth century, especially focusing improving freezing procedures and optimizing semen extenders. However, cellular biological mechanisms of damage are still unclear, which greatly restricts promotion development cryopreservation. An essential component is occurrence cell death. Considering existence multiple types death pathways, this review discusses connections between characteristics regulated (e.g., apoptosis ferroptosis), accidental intracellular ice crystals) with explores possible future directions field.
Language: Английский
Citations
32
BMEMat, Journal Year: 2024, Volume and Issue: unknown
Published: March 4, 2024
Abstract Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages high penetration, non‐radiation, and excellent oxidative stress effect, but always suffered from self‐protection mechanism apoptosis resistance characteristics evolutionarily mutated cells. Regulated cell death (RCD) received increasing attention in precision treatments because significant role synergistically sensitizing reversing immunosuppressive microenvironment during SDT nanomedicine‐triggered immunogenic death. Herein, paradigmatic research RCD‐augmented tumor immunotherapeutics are typically introduced, such autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, coordinated anti‐tumor mechanisms discussed detail. Multiple analysis focusing on currently unsolved problems future development prospects RCD‐based nano‐oncology medicine also prospected further strengthen expand scope therapeutic applications.
Language: Английский
Citations
20
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 150631 - 150631
Published: March 26, 2024
The skeletal system is essential for preserving body structure and facilitating mobility; however, bone diseases frequently result in significant disabilities, necessitating the investigation into biomaterials restoration. Nevertheless, these may elicit immune reactions that obstruct healing process. Macrophages assume a pivotal role modulating inflammation sustaining homeostasis regeneration. A comprehensive understanding of molecular interactions between macrophages imperative development sophisticated designed to regulate environment promote remodeling. This review delves generation, polarization, interaction with principal cell types implicated osteogenesis, detailing mechanisms by which influence repair their response biomaterials. Additionally, it discusses strategies precise modulation macrophage functionality via intelligent mechanisms, outlines challenges constraints designing integrate functions. By elucidating challenges, lays groundwork creation advanced endowed smart immunomodulatory capabilities, heralding novel approaches treatment defects advancement regeneration therapies.
Language: Английский
Citations
20
Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(11)
Published: Nov. 26, 2024
Abstract Regulated cell death (RCD) refers to the form of that can be regulated by various biomacromolecules. Each modalities have their distinct morphological changes and molecular mechanisms. However, intense evidences suggest lipid peroxidation common feature initiates propagates death. Excessive alters property membrane further damage proteins nucleic acids, which is implicated in human pathologies. Here, we firstly review classical chain process peroxidation, clarify current understanding myriad roles mechanisms RCD types. We also discuss how involves diseases such intimate association between peroxidation-driven leveraged develop rational therapeutic strategies.
Language: Английский
Citations
19
Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 149 - 149
Published: Jan. 19, 2025
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder marked by the progressive degeneration of midbrain dopaminergic neurons and resultant locomotor dysfunction. Despite over two centuries recognition as chronic disease, exact pathogenesis PD remains elusive. The onset progression involve multiple complex pathological processes, with dysfunctional autophagy elevated oxidative stress serving critical contributors. Notably, emerging research has underscored interplay between in pathogenesis. Given limited efficacy therapies targeting either dysfunction or stress, it crucial to elucidate intricate mechanisms governing their develop more effective therapeutics. This review overviews role nuclear factor erythroid 2-related 2 (Nrf2), pivotal transcriptional regulator orchestrating cellular defense against these processes. By elucidating key processes PD, this will deepen our comprehensive understanding multifaceted underlying may uncover potential strategies for its prevention treatment.
Language: Английский
Citations
4
ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: 16(2), P. 223 - 231
Published: Jan. 7, 2025
Endoplasmic reticulum (ER) stress and autophagy (ER-phagy) occurring in nerve cells are crucial physiological processes closely associated with Alzheimer's disease (AD). Visualizing the two is paramount to advance our understanding of AD pathologies. Among biomarkers identified, peroxynitrite (ONOO-) emerges as a key molecule initiation aggravation ER ER-phagy, highlighting its significance underlying mechanisms processes. In this work, we designed synthesized an innovative ONOO--responsive AIEgen-based fluorescent probe (DHQM) ability monitor ER-phagy model cells. DHQM demonstrated excellent aggregation-induced emission (AIE) properties, endowing it outstanding for washing-free intracellular imaging. Meanwhile, exhibited high sensitivity, remarkable selectivity ONOO-, exceptional ER-targeting ability. The was successfully applied fluorescence imaging ONOO- fluctuations assess status aluminum-induced Our findings revealed that ferroptosis, regulated cell death process, pivotal excessive production, which turn activated exacerbated stress. Furthermore, aluminum-stimulated observed utilizing DHQM, might be inhibiting ferroptosis mitigating aberrant Overall, study not only offers valuable insights into pathological at level but also opens new potential therapeutic avenues targeting these pathways.
Language: Английский
Citations
3
Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 13, 2025
Autophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase, actively not only oncogenesis but also inflammatory responses. Among post-translational modifications, lysine methylation holds significant importance. There over 30 members demethylases (KDMs), which act epigenetic regulators physiological processes diseases. Importantly, KDMs abnormally expressed regulation cellular inflammation, representing a crucial affecting inflammation-related This article reviewed function proteins inflammation. Specifically, It focused on specific regulatory mechanisms underlying activation or inhibition well their abnormal By analyzing each KDM modification, this review provides reliable theoretical basis for clinical decision marking regarding abnormalities
Language: Английский
Citations
3
Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: 428, P. 137265 - 137265
Published: Jan. 16, 2025
Language: Английский
Citations
3