The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

Molecular Pharmaceutics, Journal Year: 2021, Volume and Issue: 18(5), P. 1862 - 1894

Published: March 31, 2021

Albumin is an appealing carrier in nanomedicine because of its unique features. First, it the most abundant protein plasma, endowing high biocompatibility, biodegradability, nonimmunogenicity, and safety for clinical application. Second, albumin chemical structure conformation allows interaction with many different drugs, potentially protecting them from elimination metabolism vivo, thus improving their pharmacokinetic properties. Finally, can interact receptors overexpressed diseased tissues cells, providing a feature active targeting disease site without addition specific ligands to nanocarrier. For this reason, albumin, characterized by extended serum half-life around 19 days, has potential promoting extension targeted delivery drugs. Therefore, article focuses on importance as nanodrug hydrophobic taking advantage passive well Particular attention paid breakthrough NAB-Technology, emphasis advantages Nab-Paclitaxel (Abraxane), compared solvent-based formulations Paclitaxel, i.e., CrEL-paclitaxel (Taxol) setting. role carrying anticancer compounds depicted, particular focus albumin-based that are currently undergoing trials. The sheds light power endogenous substance, such drug system, signifies vehicle performance biological systems, highlights possible future trends use system.

Language: Английский

---

Protein corona, understanding the nanoparticle–protein interactions and future perspectives: A critical review

International Journal of Biological Macromolecules, Journal Year: 2020, Volume and Issue: 169, P. 290 - 301

Published: Dec. 22, 2020

Language: Английский

---

Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 20825 - 20849

Published: Nov. 3, 2023

Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.

Language: Английский

---

Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(21), P. 9184 - 9205

Published: May 10, 2022

An inconvenient hurdle in the practice of nanomedicine is protein corona, a spontaneous collection biomolecular species by nanoparticles living systems. The corona dynamic composition and may entail improved water suspendability compromised delivery targeting to nanoparticles. How much this nonspecific ensemble determined chemistry nanoparticle core its surface functionalization, how entity dictated biological environments that vary spatiotemporally vivo? do we "live with" exploit without significantly sacrificing efficacy nanomedicines diagnosing curing human diseases? This article discusses chemical biophysical signatures ponders challenges ahead for field nanomedicine.

Language: Английский

---

Mapping and identification of soft corona proteins at nanoparticles and their impact on cellular association

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Sept. 10, 2020

Abstract The current understanding of the biological identity that nanoparticles may acquire in a given milieu is mostly inferred from hard component protein corona (HC). composition soft (SC) proteins and their relevance have remained elusive due to lack analytical separation methods. Here, we identify set specific with weak interactions at silica polystyrene by using an situ click-chemistry reaction. We show these SC are present also HC, but specifically enriched after capture, suggesting main distinction between HC differential binding strength same proteins. Interestingly, weakly interacting revealed as modulators nanoparticle-cell association mainly through dynamic nature. therefore highlight should be considered when evaluating nano-bio interfaces.

Language: Английский

---

Brush Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime

Nano Letters, Journal Year: 2021, Volume and Issue: 21(4), P. 1591 - 1598

Published: Feb. 9, 2021

For nanocarriers with low protein affinity, we show that the interaction of cells is mainly affected by density, molecular weight, and conformation polyethylene glycol (PEG) chains bound to nanocarrier surface. We achieve a reduction nonspecific uptake ovalbumin dendritic using densely packed PEG "brush" instead collapsed "mushroom" conformation. also control minor extent dysopsonin adsorption tailoring attached on nanocarriers. The brush leads stealth behavior inhibited phagocytic cells, which prerequisite for successful in vivo translation nanomedicine long blood circulation targeted delivery. can clearly correlate This study shows that, addition surface's chemistry, polymers controls cellular interactions

Language: Английский

---

The effects of protein corona on in vivo fate of nanocarriers

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 186, P. 114356 - 114356

Published: May 17, 2022

Language: Английский

---

Influence of surface chemistry and morphology of nanoparticles on protein corona formation

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2022, Volume and Issue: 14(4)

Published: March 7, 2022

Abstract Nanomaterials offer promising solutions as drug delivery systems and imaging agents in response to the demand for better therapeutics diagnostics. However, limited understanding of interaction between nanoparticles biological entities is currently hampering development new their applications clinical settings. Proteins lipids fluids are known complex with form a “biomolecular corona”. This has been shown affect particles' morphology behavior interactions cells. Hence, how nanomaterials' physicochemical properties formation composition this biocorona crucial step. work evaluates existing literature on (size shape), surface chemistry (charge hydrophobicity) influence protein corona. The latest evidence suggest that although charge promotes proteins lipids, plays leading role determining affinity nanoparticle biomolecules and, ultimately, More recently study additional nanoparticles' like shape chirality have demonstrated significant effect corona architecture, providing tools tailor biomolecular formation. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Toxicology Regulatory Issues Nanomedicine

Language: Английский

---

Myelosuppression Alleviation and Hematopoietic Regeneration by Tetrahedral‐Framework Nucleic‐Acid Nanostructures Functionalized with Osteogenic Growth Peptide

Advanced Science, Journal Year: 2022, Volume and Issue: 9(27)

Published: July 26, 2022

As major complications of chemoradiotherapy, myelosuppression and hematopoietic-system damage severely affect immunologic function can delay or even terminate treatment for cancer patients. Although several specific cytokines have been used hematopoiesis recovery, their effect is limited, they may increase the risk tumor recurrence. In this study, osteogenic growth peptide functionalized tetrahedral framework nucleic-acid nanostructures (OGP-tFNAs) are prepared; combine positive stimulating OGP drug carrying tFNAs. The potential OGP-tFNAs hematopoietic stimulation microenvironment regulation investigated. It shown that protect bone marrow stromal cells from 5-fluorouracil (5-FU)-induced DNA apoptosis. pretreatment activates extracellularly regulated protein kinase signal downregulates apoptosis-related proteins. also alleviate chemotherapy-induced inhibition hematopoiesis-related cytokine expression, which crucial reconstitution. conclusion, injuries myelosuppression, while promoting regeneration.

Language: Английский

---

Advanced strategies to evade the mononuclear phagocyte system clearance of nanomaterials

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Jan. 5, 2023

Nanomaterials are promising carriers to improve the bioavailability and therapeutic efficiency of drugs by providing preferential drug accumulation at their sites action, but delivery efficacy is severely limited a series biological barriers, especially mononuclear phagocytic system (MPS)-the first major barrier encountered systemically administered nanomaterials. Herein, current strategies for evading MPS clearance nanomaterials summarized. First, engineering methods including surface modification, cell hitchhiking, physiological environment modulation reduce explored. Second, disabling blockade, suppression macrophage phagocytosis, macrophages depletion examined. Last, challenges opportunities in this field further discussed.

Language: Английский

---