Child type 1 diabetes associated with mother vaginal bacteriome and mycobiome DOI Creative Commons
Anna Liisa Ruotsalainen, Mysore V. Tejesvi, Petri Vänni

et al.

Medical Microbiology and Immunology, Journal Year: 2022, Volume and Issue: 211(4), P. 185 - 194

Published: June 14, 2022

Mother vaginal microbes contribute to microbiome of vaginally delivered neonates. Child can be associated with autoimmune diseases, such as type 1 diabetes (T1D). We collected DNA samples from 25 mothers a child diagnosed T1D and 24 control who had healthy analyzed bacteriome mycobiome the samples. The total was extracted, ribosomal regions (16S for bacteria, ITS2 fungi) were amplified, followed by next-generation sequencing machine learning. found that alpha-diversity increased (P < 0.002), whereas decreased 0.001) in diabetic compared mothers. Beta-diversity analysis suggested differences mycobiomes between mother groups = 0.001). Random forest models able effectively predict status unknown (bacteria: 0.86 AUC, fungi: 0.96 AUC). Our data indicate several fungal genera bacterial metabolic pathways T1D. suggest early onset has relationship altered both this shift.

Language: Английский

Maternal anxiety, depression and stress affects offspring gut microbiome diversity and bifidobacterial abundances DOI Creative Commons
Jeffrey D. Galley, Lauren Mashburn‐Warren,

Lexie C. Blalock

et al.

Brain Behavior and Immunity, Journal Year: 2022, Volume and Issue: 107, P. 253 - 264

Published: Oct. 12, 2022

Language: Английский

Citations

80
Microbial diversity in the vaginal microbiota and its link to pregnancy outcomes DOI Creative Commons

Agnes Baud,

Kenzo-Hugo Hillion, Céline Plainvert

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 4, 2023

Abstract The vaginal microbiota refers to the microorganisms that reside in vagina. These contribute significantly a woman’s reproductive and general health. A healthy is typically low-diversity environment with predominance of lactic acid-producing Lactobacillus species. Factors such as antibiotic use, sexual activity, hormonal changes can disrupt balance microbiota, leading conditions bacterial vaginosis. composition takes on added importance during pregnancy, serving barrier against infection for both mother fetus. Despite colonize vagina, details how diversity impact pregnancy outcomes poorly understood. This especially true woman high prevalence Gardnerella vaginalis . Here we report diverse cohort 749 women, enrolled InSPIRe cohort, their final trimester pregnancy. We show Lactobacilli , including L. crispatus are important maintaining low diversity, depletion this critical community linked preterm delivery. further demonstrate it overall not specific species, which provides best indicator risk.

Language: Английский

Citations

54
Effects of vaginal microbiota transfer on the neurodevelopment and microbiome of cesarean-born infants: A blinded randomized controlled trial DOI Creative Commons

Lepeng Zhou,

Wen Qiu, Jie Wang

et al.

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(7), P. 1232 - 1247.e5

Published: June 16, 2023

Language: Английский

Citations

51
Prenatal opioid exposure and subsequent risk of neuropsychiatric disorders in children: nationwide birth cohort study in South Korea DOI Creative Commons
Jiseung Kang, Hyeon Jin Kim,

Tae Kim

et al.

BMJ, Journal Year: 2024, Volume and Issue: unknown, P. e077664 - e077664

Published: April 24, 2024

Summary Objective To investigate the potential association between prenatal opioid exposure and risk of neuropsychiatric disorders in children. Design Nationwide birth cohort study. Setting From 1 January 2009 to 31 December 2020, data pregnant women South Korea linked their liveborn infants from National Health Insurance Service were collected. Participants All 3 251 594 (paired mothers, n=2 369 322; age 32.1 years (standard deviation 4.2)) start 2010 end 2017, with follow-up date until death or included. Main outcome measures Diagnosis mental behaviour (International Classification Diseases 10th edition codes F00-99). Follow-up continued first diagnosis disorder, 2020 (end study period), death, whichever occurred first. Eight cohorts created: three (full unmatched, propensity score matched, child screening cohorts) formed, all which paired sibling comparison cohorts, addition two more groups. Multiple subgroup analyses performed. Results Of 128 571 included (from 2 299 664 mothers), we identified 912 559 (51.3% male, 48.7% female) no 216 012 (51.2% 48.8% exposure. The was 1.07 (95% confidence interval 1.05 1.10) for fully adjusted hazard ratio matched cohort, but significant noted (hazard 1.00 (0.93 1.07)). Prenatal during trimester (1.11 (1.07 1.15)), higher doses (1.15 (1.09 1.21)), long term use 60 days (1.95 (1.24 3.06)) associated an increased child. modestly severe (1.30 1.46)), mood disorders, attention deficit hyperactivity intellectual disability Conclusions Opioid pregnancy not a substantial increase offspring. A slightly observed, this should be considered clinically meaningful given observational nature study, limited high dose, than one used, longer duration exposure, early pregnancy, only some disorders.

Language: Английский

Citations

21
Vaginal microbiota transplantation is a truly opulent and promising edge: fully grasp its potential DOI Creative Commons
Yiming Meng, Jing Sun, Guirong Zhang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: March 22, 2024

Vaginal microbiota transplantation (VMT) is a cutting-edge treatment modality that has the potential to revolutionize management of vaginal disorders. The human vagina complex and dynamic ecosystem home diverse community microorganisms. These microorganisms play crucial role in maintaining health well-being female reproductive system. However, when balance this disrupted, it can lead development various Conventional treatments, such as antibiotics antifungal medications, temporarily relieve symptoms they often fail address underlying cause problem, which disruption microbiota. In recent years, VMT emerged promising therapeutic approach aims restore ecosystem. Several studies have demonstrated safety efficacy treating bacterial vaginosis, recurrent yeast infections, other conditions. procedure also shown results reducing risk sexually transmitted infections preterm birth pregnant women. more research needed establish optimal donor selection, preparation, screening protocols, well long-term efficacy. offers safe, effective, minimally invasive option for women with persistent problems. It could improve quality life millions worldwide become standard shortly. With further development, potentially treat wide range problems beyond scope

Language: Английский

Citations

16
The Microbiota–Gut–Brain Axis: Psychoneuroimmunological Insights DOI Open Access
Giuseppe Marano, Marianna Mazza, Francesco Maria Lisci

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1496 - 1496

Published: March 20, 2023

There is growing interest in the role that intestinal microbiota and related autoimmune processes may have genesis presentation of some psychiatric diseases. An alteration communication microbiota-gut-brain axis, which constitutes a communicative model between central nervous system (CNS) gastro-enteric tract, has been identified as one possible causes The purpose this narrative review to describe evidence supporting gut diseases impact diet on mental health. Change composition could determine an increase permeability barrier, leading cytokine storm. This trigger systemic inflammatory activation immune response: series events repercussions release neurotransmitters, altering activity hypothalamic-pituitary-adrenal reducing presence trophic brain factors. Although disorders seem be connected, more effort needed understand potential causative mechanisms underlying interactions these systems.

Language: Английский

Citations

41
The human vaginal microbiota: from clinical medicine to models to mechanisms DOI
Samantha Ottinger, Clare M. Robertson, Holly Branthoover

et al.

Current Opinion in Microbiology, Journal Year: 2024, Volume and Issue: 77, P. 102422 - 102422

Published: Jan. 11, 2024

Language: Английский

Citations

9
Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy DOI Creative Commons
Kathryn McCauley, Elze Rackaityte,

Brandon LaMere

et al.

Cell Reports Medicine, Journal Year: 2022, Volume and Issue: 3(8), P. 100713 - 100713

Published: Aug. 1, 2022

Maternal asthma status, prenatal exposures, and infant gut microbiota perturbation are associated with heightened risk of atopy in childhood, observations hypothetically linked by intergenerational microbial transmission. Using maternal vaginal (n = 184) paired stool 172) samples, we identify four compositionally functionally distinct Lactobacillus-dominated clusters (VCs) that relate to health exposures serum immunoglobulin E (IgE) status at 1 year. Variance bacteria shared between mother pairs VCs, allergy/asthma IgE levels. Heritable bacterial gene pathways include fatty acid synthesis histamine tryptophan degradation. In vitro, vertically transmitted Lactobacillus jensenii strains induce immunosuppressive phenotypes on human antigen-presenting cells. Murine supplementation L. reduces lung eosinophils, neutrophilic expansion, the proportion interleukin-4 (IL-4)+ CD4+ T Thus, heritability intimately linked, suggesting a component disease

Language: Английский

Citations

34
The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans DOI Open Access
Letícia E. Sewaybricker, Alyssa Huang, Suchitra Chandrasekaran

et al.

Endocrine Reviews, Journal Year: 2022, Volume and Issue: 44(2), P. 281 - 296

Published: Oct. 17, 2022

Abstract Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis are underlying causal components of diet-induced obesity in rodent models. This review summarizes synthesizes available translational data to better understand the applicability findings human its comorbidities. The published humans includes histopathologic analyses performed postmortem vivo neuroimaging studies measuring indirect markers tissue microstructure. Both support presence children adults with obesity. Findings predominantly point changes region arcuate nucleus hypothalamus, although altered characteristics whole hypothalamus or other regions also emerged. Moreover, severity has been related comorbid conditions, including glucose intolerance, insulin resistance, type 2 diabetes, low testosterone levels men, independent elevated body adiposity. Cross-sectional augmented by a small number prospective suggesting greater degree may predict adiposity gain worsening sensitivity susceptible individuals. In conclusion, existing corroborate large demonstrating neuroinflammatory responses play role pathogenesis. Extensive permanent remodeling negatively affect function neuroendocrine regulatory circuits promote development maintenance weight and/or endocrine disorders.

Language: Английский

Citations

30
Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy DOI Creative Commons
Hannah C. Zierden,

Ruth Marx-Rattner,

Kylie D. Rock

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: March 20, 2023

Abstract Homeostatic regulation of the maternal milieu during pregnancy is critical for and fetal health. The placenta facilitates communication between compartments, in part, through production extracellular vesicles (EVs). EVs enable tissue synchrony via cell–cell long-distance are at their highest circulating concentration pregnancy. While much work has been done investigating how physiological challenges affect fetus, role placental health not well examined. We previously identified O-glycosyl transferase (OGT), a glucose-sensing enzyme, as target stress where OGT levels activity affected O-glycosylation proteins EV cargo loading secretion. Here, we hypothesized that plays an essential homeostatic its concentrations. Our studies found changes to key metabolic factors over circadian cycle, including glucocorticoids, insulin, glucose, were significantly associated with concentration. Targeting mice, novel significant positive relationship was improving glucose tolerance Finally, intravenous elevation EVs, matching pregnancy, shifted non-pregnant female sensitivity, blunted variance, improved uptake. These data suggest important regulators

Language: Английский

Citations

21