BF2‐Bridged Azafulvene Dimer‐Based 1064 nm Laser‐Driven Superior Photothermal Agent for Deep‐Seated Tumor Therapy DOI

Mingwang Yang,

Xinwen Ou, Jianwei Li

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(34)

Published: June 13, 2024

Abstract Small organic photothermal agents (PTAs) with absorption bands located in the second near‐infrared (NIR‐II, 1000–1700 nm) window are highly desirable for effectively combating deep‐seated tumors. However, rarely reported NIR‐II absorbing PTAs still suffer from a low molar extinction coefficient (MEC, ϵ ), inadequate chemostability and photostability, as well high light power density required during therapeutic process. Herein, we developed series of boron difluoride bridged azafulvene dimer acceptor‐integrated small PTAs. The B‐N coordination bonds π‐conjugated backbone endow it strong electron‐withdrawing ability, facilitating vigorous donor‐acceptor‐donor (D‐A‐D) structure absorption. Notably, PTA namely OTTBF shows MEC (7.21×10 4 M −1 cm ultrahigh chemo‐ photo‐stability. After encapsulated into water‐dispersible nanoparticles, NPs can achieve remarkable conversion effect under 1064 nm irradiation 0.7 W −2 , which is lowest used PTT process know. Furthermore, have been successfully applied vitro vivo cancer treatments laser. This study provides an insight future exploration versatile D‐A‐D structured biomedical applications.

Language: Английский

Anti‐Quenching NIR‐II J‐Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics DOI
Ka‐Wai Lee,

Yijian Gao,

Wei‐Chih Wei

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(20)

Published: March 3, 2023

Molecular fluorophores with the second near-infrared (NIR-II) emission hold great potential for deep-tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J-aggregates are used construct long-wavelength NIR-II emitters as optical bands show remarkable red shifts upon forming water-dispersible nano-aggregates. However, wide applications in fluorescence imaging impeded by limited varieties of J-type backbone serious quenching. Herein, a bright benzo[c]thiophene (BT) J-aggregate fluorophore (BT6) anti-quenching effect is reported highly efficient phototheranostics. The BT manipulated have Stokes shift over 400 nm aggregation-induced (AIE) property conquering self-quenching issue fluorophores. Upon BT6 assemblies an aqueous environment, absorption 800 1000 boosted more than 41 26 folds, respectively. In vivo visualization whole-body blood vessel imaging-guided phototherapy results verify that NPs agent cancer This work develops strategy precisely properties biomedical applications.

Language: Английский

Citations

108
Near-infrared II fluorescence imaging DOI
E. Schmidt, Zihao Ou, Erving Ximendes

et al.

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: April 4, 2024

Language: Английский

Citations

77
Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region DOI
Yang Yang,

Qunying Jiang,

Fan Zhang

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(2), P. 554 - 628

Published: Nov. 22, 2023

In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.

Language: Английский

Citations

74
A Water‐Soluble AIEgen for Noninvasive Diagnosis of Kidney Fibrosis via SWIR Fluorescence and Photoacoustic Imaging DOI
Dingyuan Yan, Tingting Li, Yilin Yang

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(50)

Published: Oct. 12, 2022

Early diagnosis of renal fibrosis is crucially significant on account its worldwide prevalent tendency. Optical imaging in the near-infrared window has been recognized as an appealing technique for timely detection dysfunction. However, formulating a contrast agent that allows early monitoring and concurrently renally clearable normal group still challenging. Herein, nanosized fluorophore with aggregation-induced emission (AIE) features, namely AIE-4PEG550 NPs, well-tailored amenable to longitudinal visualization progression specifically early-stage via short-wave infrared (SWIR, 900-1700 nm) fluorescence photoacoustic bimodal imaging. The small size (≈26 nm), filtrable molecular weight (3.3 kDa), high clearance efficiency (93.1 ± 1.7% excretion through kidneys within 24 h), outstanding performance, good biocompatibility, together make NPs remarkably impressive far superior clinical diagnostic assays. finding this study would provide blueprint next generation agents extent fibrosis.

Language: Английский

Citations

73
More Is Better: Dual-Acceptor Engineering for Constructing Second Near-Infrared Aggregation-Induced Emission Luminogens to Boost Multimodal Phototheranostics DOI
Shiping Yang, Jianyu Zhang, Zhijun Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(41), P. 22776 - 22787

Published: Oct. 9, 2023

The manipulation of electron donor/acceptor (D/A) shows an endless impetus for innovating optical materials. Currently, there is booming development in donor design, while research on acceptor engineering has received limited attention. Inspired by the philosophical idea "more different", two systems with D'-D-A-D-D' (1A system) and D'-D-A-A-D-D' (2A structures based were designed studied. It was demonstrated that 1A system presented a weak aggregation-induced emission (AIE) to aggregation-caused quenching (ACQ) phenomenon, along increased electrophilicity planarity. In sharp contrast, 2A one more exhibited opposite ACQ-to-AIE transformation. Interestingly, fluorophore electron-deficient A-A moiety displayed superior AIE activity. More importantly, all compounds showed significantly higher molar absorptivity (ε) comparison their counterparts system. Thanks highest ε, near-infrared-II (NIR-II, 1000-1700 nm) emission, desirable property, favorable reactive oxygen species (ROS) generation, high photothermal conversion efficiency, representative member handily performed fluorescence-photoacoustic-photothermal multimodal imaging-guided photodynamic-photothermal collaborative therapy efficient tumor elimination. Meanwhile, NIR-II fluorescence imaging blood vessels lymph nodes living mice also accomplished. This study provides first evidence dual-connected tactic could be new molecular design direction effect, resulting aggregation-intensified improved ROS heat generation capacities phototheranostic agents.

Language: Английский

Citations

62
Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition DOI Creative Commons
Huizhen Ma, Xiaoning Zhang, Ling Liu

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(31)

Published: Aug. 2, 2023

Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to conflicts in free electron utilization, resulting a lack of bioactivity most near-infrared-II (NIR-II) fluorophores. To circumvent this challenge, we developed atomically precise Au22 clusters with strong NIR-II ranging from 950 1300 nm exhibiting potent enzyme-mimetic through atomic engineering create active Cu single-atom sites. The Au21Cu1 show 18-fold higher antioxidant, 90-fold catalase-like, 3-fold superoxide dismutase-like than clusters, negligible loss. Doping single atoms decreases the bandgap 1.33 1.28 eV by predominant contributions d states, lost states effectuates activities. renal clearable can monitor cisplatin-induced injury 20- 120-minute window visualize it three dimensions using light-sheet microscopy. Furthermore, inhibit oxidative stress inflammation cisplatin-treated mouse model, particularly kidneys brain.

Language: Английский

Citations

55
Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents DOI
Dandan Ma, Hui Bian,

Mingrui Gu

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215677 - 215677

Published: Jan. 31, 2024

Language: Английский

Citations

44
Recent advances in highly-efficient near infrared OLED emitters DOI Creative Commons
Paloma L. dos Santos, Patrycja Stachelek, Youhei Takeda

et al.

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 8(7), P. 1731 - 1766

Published: Jan. 1, 2024

This work describes recent developments in near-infrared (NIR) organic light-emitting diode (OLED) emitters. We discuss applications of NIR OLEDs as well various groups highly luminescent materials used the OLED emissive layer.

Language: Английский

Citations

37
2, 1, 3‐Benzothiadiazole Derivative Small Molecule Fluorophores for NIR‐II Bioimaging DOI

Zhen Hu,

Lili Feng, Piaoping Yang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)

Published: Jan. 4, 2024

Abstract Second near‐infrared (NIR‐II) bioimaging technology shows broad application prospects in the field of biomedical due to its significant superiority deep tissue penetration and high signal‐to‐background ratio. Among them, organic small molecule fluorophores have received progressively more consideration their low biotoxicity, biocompatibility, rapid clearance, good modification properties. As key acceptor core, 2, 1, 3‐benzothiadiazole (BTD) derivative plays an essential role construction donor‐acceptor‐donor type NIR‐II fluorophores. This mini‐review summarizes research development based on BTD derivatives bioimaging, focusing molecular design photophysical properties, introduces a part applications biological field. Furthermore, challenges BTD‐based future are discussed .

Language: Английский

Citations

21
Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs DOI
Lizhen Xu, Qian Zhang, Xin Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

Citations

20