Nano-Based Strategies Aiming at Tumor Microenvironment for Improved Cancer Therapy DOI
Tianhui Liu,

Changshun Lu,

Xue Jiang

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy chemotherapy, often lack specificity, leading collateral damage normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, elevated ATP levels factors that collectively promote tumor growth metastasis. This review provides comprehensive overview of the nanoparticles developed in recent years for TME-responsive strategies or TME-modulating methods therapy. The focus on designing synthesizing can interact with achieve precisely controlled drug release. These activate release under specific conditions within environment, thereby enhancing efficacy drugs while reducing toxicity cells. Moreover, simply eliminating cells does not fundamentally solve problem. Only comprehensively regulating TME make it unsuitable cell survival proliferation we more thorough therapeutic effects reduce risk recurrence. regulation aim suppress metastasis modulating various components TME. only improve treatment outcomes but also have potential lay foundation future personalized cancer therapies.

Language: Английский

Reprogramming the immunosuppressive tumor microenvironment through nanomedicine: an immunometabolism perspective DOI Creative Commons
Jieyu Liu, Yinan Bai, Yinggang Li

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 107, P. 105301 - 105301

Published: Aug. 23, 2024

Increasing evidence indicates that immunotherapy is hindered by a hostile tumor microenvironment (TME) featured with deprivation of critical nutrients and pooling immunosuppressive metabolites. Tumor cells outcompete immune effector for essential nutrients. Meanwhile, wide range cell-derived toxic metabolites exerts negative impacts on anti-tumor response, diminishing the efficacy immunotherapy. Nanomedicine excellent targetability offers novel approach to improving cancer via metabolically reprogramming TME. Herein, we review recent strategies enhancing immunotherapeutic effects through rewiring metabolism nanomedicine. Attention drawn immunometabolic tactics stromal in TME Additionally, discuss future directions developing metabolism-regulating nanomedicine precise efficacious

Language: Английский

Citations

86
Cancer cell metabolism and antitumour immunity DOI
Mara De Martino, Jeffrey C. Rathmell, Lorenzo Galluzzi

et al.

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: 24(9), P. 654 - 669

Published: April 22, 2024

Language: Английский

Citations

69
Hierarchically Micro-, Meso-, and Macro-Porous MOF Nanosystems for Localized Cross-Scale Dual-Biomolecule Loading and Guest-Carrier Cooperative Anticancer Therapy DOI

Qiaomei Ke,

Ke Jiang, Hong Li

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(33), P. 21911 - 21924

Published: Aug. 5, 2024

Mass transfer of bulky molecules,

Language: Английский

Citations

26
A Multifunctional Bimetallic Nanoplatform for Synergic Local Hyperthermia and Chemotherapy Targeting HER2‐Positive Breast Cancer DOI Creative Commons
Li Zhao, Fei Chang, Yao Tong

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Anti-HER2 (human epidermal growth factor receptor 2) therapies significantly increase the overall survival of patients with HER2-positive breast cancer. Unfortunately, a large fraction may develop primary or acquired resistance. Further, multidrug combination used to prevent this in clinic places significant burden on patients. To address issue, work develops nanotherapeutic platform that incorporates bimetallic gold-silver hollow nanoshells (AuAg HNSs) exceptional near-infrared (NIR) absorption capability, small-molecule tyrosine kinase inhibitor pyrotinib (PYR), and Herceptin (HCT). This realizes targeted delivery multiple therapeutic effects, including chemo-and photothermal activities, oxidative stress, immune response. In vitro assays reveal HCT-modified nanoparticles exhibit specific recognition ability effective internalization by cells. The released PYR inhibit cell proliferation downregulating HER2 its associated pathways. NIR laser application induces effect tumor apoptosis, whereas an intracellular reactive oxygen species burst amplifies stress triggers cancer ferroptosis. Importantly, multimodal therapy also promotes upregulation genes related TNF NF-κB signaling pathways, enhancing activation immunogenic death. vivo studies confirm reduction volume after treatment, substantiating potential effectiveness these nanocarriers.

Language: Английский

Citations

22
Multifunctional Copper‐Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer Immunotherapy DOI
Guo‐Qing Zhu, Yulin Xie, Junrong Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(45)

Published: Sept. 17, 2024

Abstract The overexpression of polyamines in tumor cells contributes to the establishment immunosuppressive microenvironment and facilitates growth. Here, it have ingeniously designed multifunctional copper‐piceatannol/HA nanopills (Cu‐Pic/HA NPs) that effectively cause total intracellular depletion by inhibiting synthesis, depleting polyamines, impairing uptake, resulting enhanced pyroptosis cuproptosis, thus activating a powerful immune response achieve anti‐tumor therapy. Mitochondrial dysfunction from overall not only leads surge copper ions mitochondria, thereby causing aggregation toxic proteins induce but also triggers accumulation reactive oxygen species (ROS) within which further upregulates expression zDHHC5 zDHHC9 promote palmitoylation gasdermin D (GSDMD) GSDMD‐N, ultimately inducing pyroptosis. Then occurrence cuproptosis is conductive remodel microenvironment, responses growth metastasis. This therapeutic strategy through comprehensive provides novel template for cancer immunotherapy.

Language: Английский

Citations

20
CRISPR–Cas9 applications in T cells and adoptive T cell therapies DOI Creative Commons
Xiaoying Chen,

Shuhan Zhong,

Yonghao Zhan

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: April 12, 2024

Abstract T cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade adoptive therapies. Their diverse characteristics can be reprogrammed by different challenges dependent on antigen stimulation levels, metabolic conditions, the degree of inflammation. cell-based therapeutic strategies are gaining widespread adoption in oncology treating inflammatory conditions. Emerging researches reveal that clustered regularly interspaced palindromic repeats–associated protein 9 (CRISPR–Cas9) genome editing has enabled cells more adaptable specific microenvironments, opening door advanced therapies preclinical clinical trials. CRISPR–Cas9 edit both primary engineered cells, including CAR-T TCR-T, vivo vitro regulate differentiation activation states. This review first provides a comprehensive summary role its applications studies for We also explore application CRISPR screen high-throughput technology anticipate current limitations CRISPR–Cas9, off-target effects delivery challenges, envisioned improvements related technologies disease screening, diagnosis, treatment.

Language: Английский

Citations

19
Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets DOI Creative Commons
Jean‐Ehrland Ricci

Cell Reports, Journal Year: 2025, Volume and Issue: 44(1), P. 115206 - 115206

Published: Jan. 1, 2025

Language: Английский

Citations

6
Transdermal microneedle-assisted ultrasound-enhanced CRISPRa system to enable sono-gene therapy for obesity DOI Creative Commons

Shaoyue Li,

Jing Yu, Yuting Shen

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 10, 2025

Obesity, a surging global health challenge, necessitates effective, accessible and innovative therapeutic models. Here we develop spatiotemporally controllable microneedle (MN) drug delivery platform for sono-gene therapy to fight obesity. The delivers the methoxy polyethylene glycol-polyethyleneimine (mPEG-PEI) modified metal-organic frameworks (MOFs) sonosensitizer clustered regularly interspaced short palindromic repeats-activating (CRISPRa)/CRISPRa-uncoupling protein 1 (UCP1) system intradermally adipocytes. Overall, this is capable of achieving two major strategies "annihilation" "countermeasure": one kill redundant white adipocytes by sonodynamic therapy, other promote browning through release CRISPRa-UCP1 effect. Obese male mice treated with shows significant ameliorate in glucose tolerance insulin sensitivity, successfully achieves weight loss restrains rebound. This study may enable standard treatment paradigm obesity metabolic diseases. needs effective Here, authors show loaded

Language: Английский

Citations

3
Bioactive Phosphorus Dendrimers as a Universal Protein Delivery System for Enhanced Anti-inflammation Therapy DOI
Huxiao Sun, Mengsi Zhan, Andrii Karpus

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 2195 - 2209

Published: Jan. 9, 2024

Nanocarrier-based cytoplasmic protein delivery offers opportunities to develop therapeutics; however, many systems are positively charged, causing severe toxic effects. For enhanced therapeutics, it is also of great importance design nanocarriers with intrinsic bioactivity that can be integrated drugs due the limited proteins alone for disease treatment. We report here a system based on anionic phosphite-terminated phosphorus dendrimers anti-inflammatory activity. A dendrimer termed AK-137 optimized activity was selected complex through various physical interactions. Model such as bovine serum albumin, ribonuclease A, ovalbumin, and fibronectin (FN) transfected into cells exert their respective functions, including cancer cell apoptosis, dendritic maturation, or macrophage immunomodulation. Particularly, constructed AK-137@FN nanocomplexes display powerful therapeutic effects in acute lung injury gout arthritis models by integrating both carrier protein. The developed may employed universal particularly utilized deliver fight different inflammatory diseases efficacy.

Language: Английский

Citations

17
High Entropy 2D Layered Double Hydroxide Nanosheet Toward Cascaded Nanozyme-Initiated Chemodynamic and Immune Synergistic Therapy DOI
Chen Wang,

Fengying Yuan,

Zichao Yan

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

High-entropy nanomaterials (HEMs) are a hot topic in the fields of energy and catalysis. However, terms promising biomedical applications, potential therapeutic studies involving HEMs unprecedented. Herein, we demonstrated high entropy two-dimensional layered double hydroxide (

Language: Английский

Citations

16