Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(18), P. 10920 - 10989
Published: Sept. 15, 2023
Anticancer
nanomedicines
have
been
proven
effective
in
mitigating
the
side
effects
of
chemotherapeutic
drugs.
However,
challenges
remain
augmenting
their
therapeutic
efficacy.
Nanomedicines
responsive
to
pathological
abnormalities
tumor
microenvironment
(TME)
are
expected
overcome
biological
limitations
conventional
nanomedicines,
enhance
efficacies,
and
further
reduce
effects.
This
Review
aims
quantitate
various
TME,
which
may
serve
as
unique
endogenous
stimuli
for
design
stimuli-responsive
provide
a
broad
objective
perspective
on
current
understanding
cancer
treatment.
We
dissect
typical
transport
process
barriers
drug
delivery,
highlight
key
principles
designed
tackle
series
delivery
process,
discuss
"all-into-one"
"one-for-all"
strategies
integrating
needed
properties
nanomedicines.
Ultimately,
we
insight
into
future
perspectives
toward
clinical
translation
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Sept. 20, 2021
Extracellular
vesicles
(EVs)
hold
great
promise
as
therapeutic
modalities
due
to
their
endogenous
characteristics,
however,
further
bioengineering
refinement
is
required
address
clinical
and
commercial
limitations.
Clinical
applications
of
EV-based
therapeutics
are
being
trialed
in
immunomodulation,
tissue
regeneration
recovery,
delivery
vectors
for
combination
therapies.
Native/biological
EVs
possess
diverse
properties
that
offer
stability
facilitate
crossing
biological
barriers
molecular
cargo
cells,
acting
a
form
intercellular
communication
regulate
function
phenotype.
Moreover,
important
components
paracrine
signaling
stem/progenitor
cell-based
therapies,
employed
standalone
can
be
used
drug
system.
Despite
remarkable
utility
native/biological
EVs,
they
improved
using
bio/engineering
approaches
potential.
engineered
harbor
specific
pharmaceutical
content,
enhance
stability,
modify
surface
epitopes
tropism
targeting
cells
tissues
vivo.
Limitations
currently
challenging
the
full
realization
include
scalability
standardization
generation,
characterization
design
regulation,
potency
assessment,
targeted
delivery.
The
fields'
utilization
advanced
technologies
(imaging,
quantitative
analyses,
multi-omics,
labeling/live-cell
reporters),
biocompatible
natural
sources
producing
(plants,
bacteria,
milk)
will
play
an
role
overcoming
these
Advancements
EV
engineering
methodologies
development
therapeutics,
revolutionizing
current
landscape.
OpenNano,
Journal Year:
2022,
Volume and Issue:
7, P. 100048 - 100048
Published: May 28, 2022
The
development
of
nanotechnology
as
a
crucial
technology
in
recent
years
has
resulted
new
and
creative
nanomedicine
applications.
characteristics
are
determined
by
size,
surface,
drug
loading,
targeting
potential
combination
with
diagnostic
agents
for
therapeutic
applications
to
form
nano
multifunctional
devices.
Nanomedicine
provides
healthcare
paradigm
is
capable
revitalizing
existing
clinical
products.
Polymeric
nanoparticles
(PNPs)
promising
nanomedicines.
With
increasing
demands
medical,
pharmaceutical,
or
nutritional
applications,
(NPs)
require
high
reproducibility,
homogeneity,
control
over
their
properties;
upscaling
processes
unavoidable.
Conventional
small-scale
laboratory
synthesis
techniques
PNPs
subject
batch-to-batch
variability.
Increasing
the
installation
size
from
scale
industrial
presents
many
difficulties.
This
review
explores
advances
developing
productivity
systems
synthesizing
NPs
an
easy,
fast,
controlled
manner
challenges
development,
optimization,
enhancement,
feasibility,
fabrication.
There
advantages
use
biocompatible
biodegradable
properties.
Upscaling
occur
lot
metal
NPs,
which
can
be
reference
PNPs;
there
similar
PNPs.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(23), P. 23223 - 23261
Published: Dec. 2, 2023
Stimuli-responsive
polymers
can
respond
to
internal
stimuli,
such
as
reactive
oxygen
species
(ROS),
glutathione
(GSH),
and
pH,
biological
enzymes,
external
lasers
ultrasound,
etc.,
by
changing
their
hydrophobicity/hydrophilicity,
degradability,
ionizability,
thus
have
been
widely
used
in
biomedical
applications.
Due
the
characteristics
of
tumor
microenvironment
(TME),
stimuli-responsive
that
cater
specifically
TME
extensively
prepare
smart
nanovehicles
for
targeted
delivery
therapeutic
diagnostic
agents
tissues.
Compared
conventional
drug
nanosystems,
TME-responsive
nanosystems
many
advantages,
high
sensitivity,
broad
applicability
among
different
tumors,
functional
versatility,
improved
biosafety.
In
recent
years,
a
great
deal
research
has
devoted
engineering
efficient
polymeric
significant
improvement
made
both
cancer
diagnosis
therapy.
this
review,
we
summarize
some
advances
involving
use
polymer
nanocarriers
delivery,
imaging,
therapy,
theranostics.
Various
chemical
stimuli
will
be
described
context
nanosystems.
Accordingly,
groups
responsible
responsiveness
strategies
incorporate
these
into
discussed
detail.
With
on
topic
expending
at
fast
pace,
innovative
concepts,
sequential
cascade
release,
NIR-II
multifunctional
formulations,
emerged
popular
enhanced
performance,
which
also
included
here
with
up-to-date
illustrations.
We
hope
review
offer
valuable
insights
selection
optimization
help
accelerate
future
applications
treatment.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(6), P. 5187 - 5210
Published: March 10, 2023
Red
blood
cells
(RBCs)
and
RBC
membrane-derived
nanoparticles
have
been
historically
developed
as
bioinspired
drug
delivery
systems
to
combat
the
issues
of
premature
clearance,
toxicity,
immunogenicity
synthetic
nanocarriers.
RBC-based
possess
characteristics
including
biocompatibility,
biodegradability,
long
circulation
time,
which
make
them
suited
for
systemic
administration.
Therefore,
they
employed
in
designing
optimal
formulations
various
preclinical
models
clinical
trials
treat
a
wide
range
diseases.
In
this
review,
we
provide
an
overview
biology,
synthesis,
characterization
based
on
RBCs
their
membrane
whole
RBCs,
membrane-camouflaged
nanoparticles,
RBC-derived
extracellular
vesicles,
hitchhiking.
We
also
highlight
conventional
latest
engineering
strategies,
along
with
therapeutic
modalities,
enhanced
precision
effectiveness
delivery.
Additionally,
focus
current
state
applications
translation
carriers,
well
discussing
opportunities
challenges
associated
these
systems.
Advanced Drug Delivery Reviews,
Journal Year:
2023,
Volume and Issue:
201, P. 115049 - 115049
Published: Aug. 12, 2023
Mesoporous
silica
nanoparticles
(MSNs)
have
attracted
the
attention
of
chemists,
who
developed
numerous
systems
for
encapsulation
a
plethora
molecules,
allowing
use
mesoporous
biomedical
applications.
MSNs
been
extensively
studied
their
in
nanomedicine,
applications
such
as
drug
delivery,
diagnosis,
and
bioimaging,
demonstrating
significant
vivo
efficacy
different
preclinical
models.
Nevertheless,
transition
into
clinical
trials,
it
is
imperative
to
understand
characteristics
that
make
effective
safe.
The
biosafety
properties
are
greatly
influenced
by
physicochemical
particle
shape,
size,
surface
modification,
framework.
In
this
review,
we
compile
most
relevant
recent
progress
literature
up
present
analyzing
contributions
on
biodistribution,
biodegradability,
clearance
MSNs.
Furthermore,
ongoing
trials
potential
challenges
related
administration
materials
advanced
therapeutics
discussed.
This
approach
aims
provide
solid
overview
state-of-the-art
field
encourage
translation
clinic.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(31)
Published: June 15, 2022
Immunotherapy
has
received
tremendous
attention
for
tumor
treatment,
but
the
efficacy
is
greatly
hindered
by
insufficient
tumor-infiltration
of
immune
cells
and
immunosuppressive
microenvironment.
The
strategy
that
can
efficiently
activate
cytotoxic
T
lymphocytes
inhibit
negative
regulators
will
amplify
immunotherapy
outcome,
which
however
very
rare.
Herein,
a
new
kind
semiconducting
polymer
(SP)
nanoparticles
developed,
featured
with
surface-mimicking
protein
secondary
structure
(SPSS
NPs)
self-synergistic
cancer
combining
immunogenic
cell
death
(ICD)
checkpoint
blockade
therapy.
SPs
excellent
photodynamic
property
are
synthesized
rational
fluorination,
massively
induce
ICD.
Additionally,
peptide
antagonists
introduced
self-assembled
into
β-sheet
structures
on
NP
surface
via
preparation
process
optimization,
function
as
efficient
lysosome-targeting
chimaeras
(LYTACs)
to
mediate
degradation
programmed
ligand-1
(PD-L1)
in
lysosome.
In
vivo
experiments
demonstrate
SPSS
NPs
not
only
elicit
strong
antitumor
immunity
suppress
both
primary
distant
tumor,
also
evoke
long-term
immunological
memory
against
rechallenge.
This
work
introduces
robust
agents
well-designed
photosensitizer-based
ICD
induction
structures-mediated
LYTAC-like
multivalence
PD-L1
blockade,
rendering
great
promise
synergistic
immunotherapy.
