Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

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Advances of medical nanorobots for future cancer treatments

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: July 14, 2023

Early detection and diagnosis of many cancers is very challenging. Late stage a cancer always leads to high mortality rates. It imperative develop novel more sensitive effective therapeutic methods for treatments. The development new treatments has become crucial aspect medical advancements. Nanobots, as one the most promising applications nanomedicines, are at forefront multidisciplinary research. With progress nanotechnology, nanobots enable assembly deployment functional molecular/nanosized machines increasingly being utilized in treatment. In recent years, various practical have transitioned from theory practice, vitro experiments vivo applications. this paper, we review analyze advancements treatments, with particular emphasis on their key fundamental features drug delivery, tumor sensing diagnosis, targeted therapy, minimally invasive surgery, other comprehensive At same time, discuss challenges potential research opportunities revolutionizing future, expected sophisticated capable performing multiple functions tasks, ultimately becoming true nanosubmarines bloodstream.

Language: Английский

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Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: Integration of herbal medicine, enzyme engineering, and nanotechnology

Journal of Pharmaceutical Analysis, Journal Year: 2022, Volume and Issue: 13(3), P. 239 - 254

Published: Dec. 30, 2022

Flavonoids such as baohuoside I and icaritin are the major active compounds in Epimedii Folium (EF) possess excellent therapeutic effects on various diseases. Encouragingly, 2022, soft capsules were approved to reach market for treatment of hepatocellular carcinoma (HCC) by National Medical Products Administration (NMPA) China. Moreover, recent studies demonstrate that can serve immune-modulating agent exert anti-tumor effects. Nonetheless, both production efficiency clinical applications epimedium flavonoids have been restrained because their low content, poor bioavailability, unfavorable vivo delivery efficiency. Recently, strategies, including enzyme engineering nanotechnology, developed increase productivity activity, improve efficiency, enhance flavonoids. In this review, structure-activity relationship is described. Then, enzymatic strategies increasing highly discussed. The nanomedicines overcoming barriers improving diseases summarized. Finally, challenges an outlook translation proposed.

Language: Английский

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Melanoma Management: From Epidemiology to Treatment and Latest Advances

Cancers, Journal Year: 2022, Volume and Issue: 14(19), P. 4652 - 4652

Published: Sept. 24, 2022

Melanoma is the deadliest skin cancer, whose morbidity and mortality indicators show an increasing trend worldwide. In addition to its great heterogeneity, melanoma has a high metastatic potential, resulting in very limited response therapies currently available, which were restricted surgery, radiotherapy chemotherapy for many years. Advances knowledge about pathophysiological mechanisms of disease have allowed development new therapeutic classes, such as immune checkpoint small molecule kinase inhibitors. However, despite incontestable progress quality life survival rates patients, effectiveness still far from desired. Some adverse side effects resistance are main barriers. Thus, search better options resulted clinical trials that now investigating drugs and/or combinations. The low water solubility drugs, stability rapid metabolism limit potential use some compounds. research nanotechnology-based strategies being explored basis broad application different types nanosystems treatment melanoma. Future focus on challenges understanding make these more effective.

Language: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

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Targeted modulation of immune cells and tissues using engineered biomaterials

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(2), P. 107 - 124

Published: Jan. 30, 2023

Language: Английский

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Nanoparticles in Clinical Trials: Analysis of Clinical Trials, FDA Approvals and Use for COVID-19 Vaccines

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(1), P. 787 - 787

Published: Jan. 2, 2023

Nanoparticles are heterologous small composites that usually between 1 and 100 nanometers in size. They applied many areas of medicine with one them being drug delivery. have a number advantages as carriers which include reduced toxic effects, increased bioavailability, their ability to be modified for specific tissues or cells. Due the exciting development nanotechnology concomitant advances biotechnology medicine, clinical trials devoted nanoparticles delivery is growing rapidly. Some nanoparticles, lipid-based types, particular, played crucial role developing manufacturing two COVID-19 vaccines-Pfizer Moderna-that now widely used. In this analysis, we provide quantitative survey using during period from 2002 2021 well recent FDA-approved drugs (since 2016). A total 486 were identified clinicaltrials.gov database. The prevailing types liposomes (44%) protein-based formulations (26%) period. most commonly investigated content paclitaxel (23%), metals (11%), doxorubicin (9%), bupivacaine various vaccines (both 8%). Among nanoparticle drugs, polymeric (29%), liposomal (22%) (21%) common. also discuss differential diverse groups content, underlying factors behind trends.

Language: Английский

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Tumor Abnormality-Oriented Nanomedicine Design

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 10920 - 10989

Published: Sept. 15, 2023

Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation

Language: Английский

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AS1411 aptamer-functionalized exosomes in the targeted delivery of doxorubicin in fighting colorectal cancer

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113690 - 113690

Published: Sept. 12, 2022

Severe side effects of chemotherapy agents on vital organs are the major causes cancer-related mortality, not merely cancer disease. Encapsulating chemotherapeutic molecules in nanocarriers is a justifiable solution decreasing risk their and boosting efficiency treatment. The present study has developed doxorubicin (DOX)-loaded AS1411 (anti-nucleolin) aptamer surface-functionalized exosome (DOX-Apt-Exo) to treat colorectal both in-vitro in-vivo experimental models. HEK293-derived exosomes were loaded with DOX through incubation method nearly 13% encapsulation efficiency. Afterwards, 5-terminal carboxyl group AS1411-aptamer was converted into amine-reactive NHS esters EDC/NHS amide coupling chemistry before being conjugated amine groups surface. DLS TEM estimated designed formulation size about 200 nm. Aptamer-binding affinity cellular uptake DOX-Apt-Exo by nucleolin-overexpressing cells depicted fluorescence microscopy. Comparing cytotoxicity impact DOX-loaded exosomes, either targeted or non-targeted MTT assay, clearly verified high effectiveness ligand-receptor mediated target therapy. Subsequently, experiments which conducted four ectopic mouse models colon (5 each group) demonstrated tumor growth suppression professional long-term accumulation retention at site interaction. results suggested that aptamer-functionalized can be recommended as safe effective system site-specific drug delivery possible clinical applications cancer.

Language: Английский

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Engineered Living Materials for Advanced Diseases Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: July 12, 2023

Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.

Language: Английский

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