Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells DOI Creative Commons
Ziwen Zhong, Hao Zhang, Ke Nan

et al.

Cancer Research, Journal Year: 2023, Volume and Issue: 83(21), P. 3529 - 3543

Published: Aug. 21, 2023

As a safe, feasible, and inexpensive dietary intervention, fasting-mimicking diet (FMD) exhibits excellent antitumor efficacy by regulating metabolism boosting immunity. A better understanding of the specific mechanisms underlying immunoregulatory functions FMD could help improve expand clinical application FMD-mediated immunotherapeutic strategies. In this study, we aimed to elucidate role metabolic reprogramming induced in activation immunity against colorectal cancer. Single-cell RNA sequencing analysis intratumoral immune cells revealed that tumor-infiltrating IgA+ B were significantly reduced treatment, leading tumor regression murine cancer models. Mechanistically, delayed growth repressing B-cell class switching IgA. Therefore, FMD-induced reduction overcame suppression CD8+ T cells. The effects intervention reversed transfer. Moreover, boosted fatty acid oxidation (FAO) trigger RUNX3 acetylation, thus inactivating Cα gene transcription IgA switching. expansion was also impeded patients placed on FMD, while expression carnitine palmitoyl transferase 1A (CPT1A), rate-limiting enzyme FAO, increased. Furthermore, CPT1A negatively correlated with both secretion within Together, these results highlight holds great promise for treating degree cell infiltration FAO-associated status are potential biomarkers evaluating efficacy.Metabolic suppresses production activate inhibit growth. See related commentary Bush Perry, p. 3493.

Language: Английский

Dietary methionine starvation impairs acute myeloid leukemia progression DOI
Alan Cunningham,

Ayşegül Erdem,

Islam Alshamleh

et al.

Blood, Journal Year: 2022, Volume and Issue: 140(19), P. 2037 - 2052

Published: Aug. 19, 2022

Language: Английский

Citations

29
Molecular determinants of immunogenic cell death elicited by radiation therapy DOI

Claudia Galassi,

Vanessa Klapp, Takahiro Yamazaki

et al.

Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 20 - 32

Published: Sept. 7, 2023

Summary Cancer cells undergoing immunogenic cell death (ICD) can initiate adaptive immune responses against dead cell‐associated antigens, provided that (1) said antigens are not perfectly covered by central tolerance (antigenicity), (2) occurs along with the emission of immunostimulatory cytokines and damage‐associated molecular patterns (DAMPs) actively engage effector mechanisms (adjuvanticity), (3) microenvironment dying is permissive for initiation immunity. Finally, ICD‐driven only operate exert cytotoxic functions if target cancer enables infiltration activity. Multiple forms radiation, including non‐ionizing (ultraviolet) ionizing elicit bona fide ICD as they increase both antigenicity adjuvanticity cells. Here, we review determinants elicited radiation critically discuss strategies to reinforce immunogenicity succumbing clinically available strategies.

Language: Английский

Citations

19
Reprogramming of tissue metabolism during cancer metastasis DOI

Koelina Ganguly,

Alec C. Kimmelman

Trends in cancer, Journal Year: 2023, Volume and Issue: 9(6), P. 461 - 471

Published: March 17, 2023

Language: Английский

Citations

17
Metabolites and Immune Response in Tumor Microenvironments DOI Open Access
Salvatore Cortellino, Valter D. Longo

Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3898 - 3898

Published: July 31, 2023

The remodeled cancer cell metabolism affects the tumor microenvironment and promotes an immunosuppressive state by changing levels of macro- micronutrients releasing hormones cytokines that recruit immune cells. Novel dietary interventions such as amino acid restriction periodic fasting mimicking diets can prevent or dampen formation acting systemically on release growth factors, inhibiting proinflammatory cytokines, remodeling vasculature extracellular matrix. Here, we discuss latest research effects these therapeutic immunometabolism response future scenarios pertaining to how could contribute therapy.

Language: Английский

Citations

17
Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells DOI Creative Commons
Ziwen Zhong, Hao Zhang, Ke Nan

et al.

Cancer Research, Journal Year: 2023, Volume and Issue: 83(21), P. 3529 - 3543

Published: Aug. 21, 2023

As a safe, feasible, and inexpensive dietary intervention, fasting-mimicking diet (FMD) exhibits excellent antitumor efficacy by regulating metabolism boosting immunity. A better understanding of the specific mechanisms underlying immunoregulatory functions FMD could help improve expand clinical application FMD-mediated immunotherapeutic strategies. In this study, we aimed to elucidate role metabolic reprogramming induced in activation immunity against colorectal cancer. Single-cell RNA sequencing analysis intratumoral immune cells revealed that tumor-infiltrating IgA+ B were significantly reduced treatment, leading tumor regression murine cancer models. Mechanistically, delayed growth repressing B-cell class switching IgA. Therefore, FMD-induced reduction overcame suppression CD8+ T cells. The effects intervention reversed transfer. Moreover, boosted fatty acid oxidation (FAO) trigger RUNX3 acetylation, thus inactivating Cα gene transcription IgA switching. expansion was also impeded patients placed on FMD, while expression carnitine palmitoyl transferase 1A (CPT1A), rate-limiting enzyme FAO, increased. Furthermore, CPT1A negatively correlated with both secretion within Together, these results highlight holds great promise for treating degree cell infiltration FAO-associated status are potential biomarkers evaluating efficacy.Metabolic suppresses production activate inhibit growth. See related commentary Bush Perry, p. 3493.

Language: Английский

Citations

16