Stem cell-based therapy for human diseases

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Aug. 6, 2022

Abstract Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent cells (hPSCs) multipotent mesenchymal (MSCs), has recently emerged as key player regenerative medicine. hPSCs are defined self-renewable types conferring the ability differentiate into various cellular phenotypes of body, three germ layers. MSCs progenitor possessing self-renewal (limited vitro) differentiation potential lineages, according International Society Cell Gene Therapy (ISCT). This review provides an update on recent clinical applications using either or derived bone marrow (BM), adipose tissue (AT), umbilical cord (UC) treatment diseases, neurological disorders, pulmonary dysfunctions, metabolic/endocrine-related reproductive skin burns, cardiovascular conditions. Moreover, we discuss our own trial experiences targeted therapies setting, propose MSC origin concept how may contribute role downstream applications, with ultimate objective facilitating translational research medicine applications. The mechanisms discussed here support proposed hypothesis BM-MSCs potentially good candidates brain spinal injury treatment, AT-MSCs disorder regeneration, UC-MSCs disease acute respiratory distress syndrome treatment.

Language: Английский

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Multifunctional antimicrobial materials: From rational design to biomedical applications

Progress in Materials Science, Journal Year: 2021, Volume and Issue: 125, P. 100887 - 100887

Published: Nov. 11, 2021

Language: Английский

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The epidemiological characteristic and trends of burns globally

BMC Public Health, Journal Year: 2022, Volume and Issue: 22(1)

Published: Aug. 22, 2022

Burns is a type of injury, caused by unintentional exposure to substances high temperature, including hot liquid, solid, and objects radiating heat energy, placing burden not only on patients' families but also national healthcare systems globally. It difficult for policymakers clinicians formulate targeted management strategies burns because data current epidemiological patterns worldwide are lacking.Data were obtained from the Global Burden Disease (GBD) 2019 Study. The incidence, disability-adjusted life years (DALYs), deaths in 204 countries regions 1990 calculated stratified sex, age, geographical location, sociodemographic index (SDI). estimated annual percentage change (EAPC) DALYs, was evaluate temporal trends. All analyses performed using R software, version 4.1.1, with 2-sided P-values < .05 indicating statistically significant difference.A total 8,378,122 new cases (95% UI, 6,531,887-10,363,109cases) identified globally 2019, which almost evenly split between men women, most concentrated 10-19-year age group. Besides, account 111,292 132,392-88,188) those aged 1-4 years. measured DALYs 7,460,448.65 5,794,505.89-9,478,717.81) 67% 33% could be attributed YLLs YLDs, respectively. EAPC negative, age-standardized rate (ASR) considered decreasing regions, EAPCs negatively correlated SDI levels, universal health coverage (UHC), gross domestic product (GDP).Globally, rates burn mortality, as well number death will continuously decrease, has an increasing tendency In addition, indicated that regions. And relationship SDI, UHC index, GDP, indicate prevention depend spending per capita education level system performance, it does mean higher corresponds needs efficiency translating into individuals gains.

Language: Английский

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Emerging treatment strategies in wound care

International Wound Journal, Journal Year: 2022, Volume and Issue: 19(7), P. 1934 - 1954

Published: March 17, 2022

Abstract Wound healing is a complex process in tissue regeneration through which the body responds to dissipated cells as result of any kind severe injury. Diabetic and non‐healing wounds are considered an unmet clinical need. Currently, different strategic approaches widely used treatment acute chronic include, but not limited to, transplantation, cell therapy wound dressings, use instrument. A large number literatures have been published on this topic; however, most effective remains challenge. The dressing involves scaffold, usually using biomaterials for delivery medication, autologous stem cells, or growth factors from blood. Antibacterial anti‐inflammatory drugs also stop infection well accelerate healing. With increase ageing population leading diabetes associated cutaneous wounds, there great need improve current strategies. This research critically reviews advancement therapeutic regeneration. results recent trials suggest that modern dressings skin substitutes easiest, accessible, cost‐effective way treat with advances materials science such graphene 3D scaffold biomolecules hold significant promise. annual market value successful exceeds over $50 billion US dollars, will encourage industries academics investigate application emerging smart therapy.

Language: Английский

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Exudate Absorbing and Antimicrobial Hydrogel Integrated with Multifunctional Curcumin-Loaded Magnesium Polyphenol Network for Facilitating Burn Wound Healing

ACS Nano, Journal Year: 2023, Volume and Issue: 17(22), P. 22355 - 22370

Published: Nov. 6, 2023

Burns are among the most common causes of trauma worldwide. Reducing healing time deep burn wounds has always been a major challenge. Traditional dressings not only require lengthy medical procedure but also cause unbearable pain and secondary damage to patients. In this study, we developed an exudate-absorbing antimicrobial hydrogel with curcumin-loaded magnesium polyphenol network (Cur-Mg@PP) promote wound healing. That was composed ε-poly-l-lysine (ε-PLL)/polymer poly(γ-glutamic acid) (γ-PGA) (PP) (Cur-Mg). Because strong water absorption property ε-PLL γ-PGA, Cur-Mg@PP powder can quickly absorb exudate transform into moist viscous hydrogel, thus releasing payloads such as ion (Mg2+) curcumin (Cur). The released Mg2+ Cur demonstrated good therapeutic efficacy on analgesic, antioxidant, anti-inflammation, angiogenesis, tissue regeneration. Our findings provide strategy for accelerating

Language: Английский

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Biomimetic Asymmetric Composite Dressing by Electrospinning with Aligned Nanofibrous and Micropatterned Structures for Severe Burn Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(29), P. 32799 - 32812

Published: July 15, 2022

The surface structure and topography of biomaterials play a crucial role in directing cell behaviors fates. Meanwhile, asymmetric dressings that mimic the natural skin have been identified as an effective strategy for enhancing wound healing. Inspired by superhydrophobic lotus leaf, composite dressing was obtained constructing wettability modification on both sides sponge based electrospinning. Among them, collagen quaternized chitosan fabricated freeze-drying, followed aligned poly(ε-caprolactone) (PCL)/gelatin nanofiber hydrophilic inner layer hierarchical micronanostructure PCL/polystyrene microsphere highly hydrophobic outer constructed each side sponge. proposed combines topological morphology with material's properties to effectively prevent bacterial colonization/infection promote healing cellular behavior. In vitro experimental results confirmed promotes adhesion, proliferation, directed growth, migration. has good water absorption antibacterial properties, while biomimetic exhibits strong mechanical resistance adhesion. vivo showed can reduce inflammatory response, infection, accelerate angiogenesis epithelial regeneration, significantly severe burns. Thus, bionic is expected be promising candidate burn

Language: Английский

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Rational Design of Intelligent and Multifunctional Dressing to Promote Acute/Chronic Wound Healing

ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(9), P. 4055 - 4085

Published: Aug. 18, 2022

Currently, the clinic's treatment of acute/chronic wounds is still unsatisfactory due to lack functional and appropriate wound dressings. Intelligent multifunctional dressings are considered most advanced modalities. It essential design develop with required functions according microenvironment in clinical treatment. This work summarizes characteristics various common wounds, such as acute wound, diabetic burns scalded mucosal ulcers wound. Furthermore, factors transformation from chronic were analyzed. Then we focused on summarizing how researchers fully thoroughly combined complex modern technology ensure usability value dressing, photothermal-sensitive dressings, dressing (pH-sensitive ROS-sensitive osmotic pressure dressings), hemostatic guiding tissue regeneration microneedle 3D/4D printing Finally, revolutionary development transform existing into needs soon possible have carried out a reasonable meaningful outlook.

Language: Английский

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The Immune and Regenerative Response to Burn Injury

Cells, Journal Year: 2022, Volume and Issue: 11(19), P. 3073 - 3073

Published: Sept. 29, 2022

Burn are diverse and complex injuries that not only have local effects but also serious systemic consequences through severe prolonged inflammatory response. They caused by heat, electricity, friction, chemicals, or radiation commonly divided into superficial, superficial partial-, deep partial- full-thickness injuries. The severity of the burn depends mainly on size depth injury location, age, underlying diseases. A strong immune response makes major burns even worse causing multiple including damage to heart, lungs, blood vessels, kidneys, other organs. Burns do require surgical excision, partial-thickness, follow known progression wound healing (inflammation, proliferation, remodeling), whilst full thickness requiring excision grafting not. For these burns, intervention is required for optimal coverage, function, cosmesis. Annually millions people worldwide suffer from associated with high morbidity mortality. Fortunately, over past decades, care has significantly improved. improvement in understanding pathophysiology led developments skin grafting, fluid resuscitation, infection control nutrition This review article focuses regenerative responses following injury. In Introduction, we describe epidemiology pathophysiology. focus chapter Next, define introducing all different cell types involved. Subsequently, discuss as well some emerging novel treatments battle against burns.

Language: Английский

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Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing

Biomolecules, Journal Year: 2022, Volume and Issue: 12(12), P. 1852 - 1852

Published: Dec. 12, 2022

The skin, acting as the outer protection of human body, is most vulnerable to injury. Wound healing can often be impaired, leading chronic, hard-to-heal wounds. For this reason, searching for effective dressings that significantly enhance wound process necessary. In regard, silk fibroin, a protein derived from fibres has excellent properties, noteworthy. Silk fibroin highly biocompatible and biodegradable. It easily make various dressings, which loaded with additional substances improve healing. Dressings based on have anti-inflammatory, pro-angiogenic properties accelerate skin healing, even compared commercially available dressings. Animal studies confirm beneficial influence in Clinical research focusing also promising. These remarkable natural material creating innovative, simple, review, we summarise application biomaterials full-thickness, burn, diabetic wounds preclinical clinical settings.

Language: Английский

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Biodegradable and injectable poly(vinyl alcohol) microspheres in silk sericin-based hydrogel for the controlled release of antimicrobials: application to deep full-thickness burn wound healing

Advanced Composites and Hybrid Materials, Journal Year: 2022, Volume and Issue: 5(4), P. 2847 - 2872

Published: May 7, 2022

Language: Английский

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