Exerkines in health, resilience and disease

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 18(5), P. 273 - 289

Published: March 18, 2022

Language: Английский

---

Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome

Nutrients, Journal Year: 2019, Volume and Issue: 11(7), P. 1652 - 1652

Published: July 19, 2019

Both observational and interventional studies suggest an important role for physical activity higher fitness in mitigating the metabolic syndrome. Each component of syndrome is, to a certain extent, favorably influenced by interventions that include activity. Given prevalence its individual components (particularly obesity insulin resistance) has increased significantly recent decades, guidelines from various professional organizations have called greater efforts reduce incidence this condition components. While lead improved cannot be expected normalize resistance, lipid disorders, or obesity, combined effect increasing on these risk markers, improvement fitness, both, been shown major impact health outcomes related Exercise therapy is cost-effective intervention both prevent mitigate syndrome, but it remains underutilized. In current article, overview effects provided, along with discussion mechanisms underlying benefits being more fit physically active prevention treatment

Language: Английский

---

Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Jan. 24, 2020

The molecular mechanisms underlying the response to exercise and inactivity are not fully understood. We propose an innovative approach profile skeletal muscle transcriptome using 66 published datasets. Data collected from human studies of aerobic resistance exercise, including acute chronic training, were integrated meta-analysis methods (www.metamex.eu). Here we use gene ontology pathway analyses reveal selective pathways activated by inactivity, versus training. identify NR4A3 as one most exercise- inactivity-responsive genes, establish a role for this nuclear receptor in mediating metabolic responses exercise-like stimuli vitro. (MetaMEx) also highlights differential individuals with impairments. MetaMEx provides extensive dataset transcriptional different modes online interface readily interrogate database.

Language: Английский

---

Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(1), P. 92 - 110.e4

Published: April 18, 2019

Language: Английский

---

Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care

Cell, Journal Year: 2021, Volume and Issue: 184(6), P. 1530 - 1544

Published: March 1, 2021

The prevalence of type 2 diabetes and obesity has risen dramatically for decades is expected to rise further, secondary the growing aging, sedentary population. strain on global health care projected be colossal. This review explores latest work emerging ideas related genetic environmental factors influencing metabolism. Translational research clinical applications, including impact COVID-19 pandemic, are highlighted. Looking forward, strategies personalize all aspects prevention, management necessary improve outcomes reduce these metabolic diseases.

Language: Английский

---

Food as a circadian time cue — evidence from human studies

Nature Reviews Endocrinology, Journal Year: 2020, Volume and Issue: 16(4), P. 213 - 223

Published: Feb. 13, 2020

Language: Английский

---

Food Timing, Circadian Rhythm and Chrononutrition: A Systematic Review of Time-Restricted Eating’s Effects on Human Health

Nutrients, Journal Year: 2020, Volume and Issue: 12(12), P. 3770 - 3770

Published: Dec. 8, 2020

Introduction: Recent observations have shown that lengthening the daily eating period may contribute to onset of chronic diseases. Time-restricted (TRE) is a diet especially limits this food window. It could represent dietary approach likely improve health markers. The aim study was review how time-restricted affects human health. Method: Five general databases and six nutrition journals were screened identify all studies published between January 2014 September 2020 evaluating effects TRE on populations. Results: Among 494 articles collected, 23 finally included for analysis. overall adherence rate 80%, with 20% unintentional reduction in caloric intake. induced an average weight loss 3% fat mass. This also observed without any restriction. Interestingly, produced beneficial metabolic independently loss, suggesting intrinsic effect based realignment feeding circadian clock. Conclusions: simple well-tolerated generates many chrononutrition principles. More rigorous are needed, however, confirm those effects, understand their mechanisms assess applicability

Language: Английский

---

Exercise metabolism and adaptation in skeletal muscle

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(9), P. 607 - 632

Published: May 24, 2023

Language: Английский

---

Exercise sustains the hallmarks of health

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2022, Volume and Issue: 12(1), P. 8 - 35

Published: Oct. 29, 2022

Exercise has long been known for its active role in improving physical fitness and sustaining health. Regular moderate-intensity exercise improves all aspects of human health is widely accepted as a preventative therapeutic strategy various diseases. It well-documented that maintains restores homeostasis at the organismal, tissue, cellular, molecular levels to stimulate positive physiological adaptations consequently protect against pathological conditions. Here we mainly summarize how affects major hallmarks health, including integrity barriers, containment local perturbations, recycling turnover, integration circuitries, rhythmic oscillations, homeostatic resilience, hormetic regulation, well repair regeneration. Furthermore, current understanding mechanisms responsible beneficial response exercise. This review aimed providing comprehensive summary vital biological through which opens window application other interventions. We hope continuing investigation this field will further increase our processes involved thus get us closer identification new therapeutics improve quality life.

Language: Английский

---

Roles of circadian clocks in cancer pathogenesis and treatment

Experimental & Molecular Medicine, Journal Year: 2021, Volume and Issue: 53(10), P. 1529 - 1538

Published: Oct. 1, 2021

Abstract Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h rhythms in cellular and bodily functions across nearly all living species. These internal clock systems enable organisms to anticipate respond daily changes their environment a timely manner, optimizing temporal physiology behaviors. Dysregulation of circadian by genetic environmental risk factors increases susceptibility multiple diseases, particularly cancers. A growing number studies have revealed dynamic crosstalk between cancer pathways, providing mechanistic insights into the therapeutic utility treatment. This review will discuss roles pathogenesis, highlighting recent advances chronotherapeutic approaches for improved

Language: Английский

---