Oxidative Stress and BPA Toxicity: An Antioxidant Approach for Male and Female Reproductive Dysfunction

Antioxidants, Journal Year: 2020, Volume and Issue: 9(5), P. 405 - 405

Published: May 10, 2020

Bisphenol A (BPA) is a non-persistent anthropic and environmentally ubiquitous compound widely employed detected in many consumer products food items; thus, human exposure prolonged. Over the last ten years, studies have examined underlying molecular mechanisms of BPA toxicity revealed links among BPA-induced oxidative stress, male female reproductive defects, disease. Because its hormone-like feature, shows tissue effects on specific hormone receptors target cells, triggering noxious cellular responses associated with stress inflammation. As metabolic endocrine disruptor, impairs redox homeostasis via increase mediators reduction antioxidant enzymes, causing mitochondrial dysfunction, alteration cell signaling pathways, induction apoptosis. This review aims to examine scenery current literature understanding how can be considered “fil rouge” BPA’s toxic action pleiotropic outcomes reproduction. Here, we focus protective five classes antioxidants—vitamins co-factors, natural (herbals phytochemicals), melatonin, selenium, methyl donors (used alone or combination)—that been found useful counteract functions.

Language: Английский

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Impacts of food contact chemicals on human health: a consensus statement

Environmental Health, Journal Year: 2020, Volume and Issue: 19(1)

Published: March 3, 2020

Abstract Food packaging is of high societal value because it conserves and protects food, makes food transportable conveys information to consumers. It also relevant for marketing, which economic significance. Other types contact articles, such as storage containers, processing equipment filling lines, are important production supply. articles made up one or multiple different materials consist chemicals. However, chemicals transfer from all into and, consequently, taken by humans. Here we highlight topics concern based on scientific findings showing that a exposure pathway known hazardous substances well plethora toxicologically uncharacterized chemicals, both intentionally non-intentionally added. We describe areas certainty, like the fact migrate uncertainty, example unidentified migrating food. Current safety assessment ineffective at protecting human health. In addition, society striving waste reduction with focus packaging. As result, solutions being developed toward reuse, recycling alternative (non-plastic) materials. critical aspect chemical often ignored. Developing improving tackling circular economy must include current knowledge. This cannot be done in isolation but experts stakeholders. Therefore, provide an overview related activities will improve support economy. Our aim initiate broader discussion involving scientists expertise not currently working materials, decision makers influencers addressing single-use due environmental concerns. Ultimately, science-based making interest public Notably, reducing contributes prevention associated chronic diseases population.

Language: Английский

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Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

Molecular Autism, Journal Year: 2020, Volume and Issue: 11(1)

Published: Sept. 10, 2020

The complex pathophysiology of autism spectrum disorder encompasses interactions between genetic and environmental factors. On the one hand, hundreds genes, converging at functional level on selective biological domains such as epigenetic regulation synaptic function, have been identified to be either causative or risk factors autism. other exposure chemicals that are widespread in environment, endocrine disruptors, has associated with adverse effects human health, including neurodevelopmental disorders. Interestingly, experimental results suggest an overlap regulatory pathways perturbed by mutations factors, depicting convergences interplays susceptibility toxic insults. pervasive nature chemical poses pivotal challenges for neurotoxicological studies, agencies, policy makers. This highlights emerging need developing new integrative models, biomonitoring, epidemiology, experimental, computational tools, able capture real-life scenarios encompassing interaction chronic mixture substances individuals' backgrounds. In this review, we address intertwined roles lesions Specifically, outline transformative potential stem cell coupled omics analytical approaches increasingly single resolution, tools experimentally dissect pathogenic mechanisms underlying disorders, well improve developmental neurotoxicology assessment.

Language: Английский

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Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring

Environment International, Journal Year: 2020, Volume and Issue: 144, P. 105811 - 105811

Published: Aug. 29, 2020

Human biomonitoring (HBM) studies have demonstrated widespread and daily exposure to bisphenol A (BPA). Moreover, BPA structural analogues (e.g. BPS, BPF, BPAF), used as replacements, are being increasingly detected in human biological matrices. some of its classified endocrine disruptors suspected contributing adverse health outcomes such altered reproduction neurodevelopment, obesity, metabolic disorders among other developmental chronic impairments. One the aims H2020 European Biomonitoring Initiative (HBM4EU) is implementation effect biomarkers at large scales future HBM a systematic standardized way, order complement data with mechanistically-based early effects. This review aimed identify prioritize existing for BPA, well provide relevant mechanistic outcome pathway (AOP) information cover knowledge gaps better interpret biomarker data. comprehensive literature search was performed PubMed all epidemiologic published last 10 years addressing potential relationship between bisphenols alterations parameters. total 5716 references were screened, out which, 119 full-text articles analyzed tabulated detail. work provides first an overview epigenetics, gene transcription, oxidative stress, reproductive, glucocorticoid thyroid hormones, allergy/immune previously studied. Then, promising related neurodevelopmental reproductive including brain-derived neurotrophic factor (BDNF), kisspeptin (KiSS), expression nuclear receptors prioritized, providing insights based on vitro, animal AOP information. Finally, omics technologies discovery implications risk assessment discussed. To best our knowledge, this effort comprehensively bisphenol-related purposes.

Language: Английский

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Update on the Health Effects of Bisphenol A: Overwhelming Evidence of Harm

Endocrinology, Journal Year: 2020, Volume and Issue: 162(3)

Published: Sept. 23, 2020

In 1997, the first in vivo bisphenol A (BPA) study by endocrinologists reported that feeding BPA to pregnant mice induced adverse reproductive effects male offspring at low dose of 2 µg/kg/day. Since then, thousands studies have animals administered doses BPA. Despite more than 100 epidemiological suggesting associations between and disease/dysfunction also animal studies, regulatory agencies continue assert exposures are safe. To address this disagreement, CLARITY-BPA was designed evaluate traditional endpoints toxicity modern hypothesis-driven, disease-relevant outcomes same set animals. wide range both mechanistic lowest tested (2.5 µg/kg/day), leading independent experts call for observed effect level (LOAEL) be dropped 20 000-fold from current outdated LOAEL 50 000 criticism members Endocrine Society Food Drug Administration (FDA)'s assumptions violate basic principles endocrinology, FDA rejected all low-dose data as not biologically plausible. Their decisions rely on 4 incorrect assumptions: responses must monotonic, there exists a threshold below which no effects, sexes respond similarly, only toxicological guideline valid. This review details years addresses divide approaches endocrine science. Ultimately, has shed light why methods evaluating insufficient disrupting chemicals.

Language: Английский

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Changes in urinary excretion of phthalates, phthalate substitutes, bisphenols and other polychlorinated and phenolic substances in young Danish men; 2009–2017

International Journal of Hygiene and Environmental Health, Journal Year: 2019, Volume and Issue: 223(1), P. 93 - 105

Published: Oct. 25, 2019

Language: Английский

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An overview of the occurrence, fate, and human risks of the bisphenol‐A present in plastic materials, components, and products

Integrated Environmental Assessment and Management, Journal Year: 2022, Volume and Issue: 19(1), P. 45 - 62

Published: April 1, 2022

With over 95% of bisphenol-A (BPA) used in the production polycarbonate (PC) and epoxy resins, termed here as BPA-based plastic materials, components, products (MCPs), an investigation human exposure to BPA whole lifecycle MCPs is necessary. This mini-review unpacks implications arising from long-term its potential accumulation across plastics (production, use, management). timely necessary promoting a sustainable circular economy model. Restrictions form bans safety standards are often specific products, while limits rely on traditional toxicological biomonitoring methods that may underestimate health therefore "safety" exposure. Controversies regards the: (a) dose-response curves; (b) complexity sources, release mechanisms, pathways exposure; and/or (c) quality reliability studies, appear currently stifle progress toward regulation MCPs. Due abundance our production, consumption, management systems, there partial inadequate evidence contribution BPA. Yet, end-of-life constitute most critical source require further investigation. Active collaboration among risk assessors, government, policy-makers, researchers needed explore impacts long term introduce restrictions Integr Environ Assess Manag 2023;19:45-62. © 2022 SETAC.

Language: Английский

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Unpacking the complexity of the PET drink bottles value chain: A chemicals perspective

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 430, P. 128410 - 128410

Published: March 4, 2022

Chemicals can migrate from polyethylene terephthalate (PET) drink bottles to their content and recycling processes may concentrate or introduce new chemicals the PET value chain. Therefore, even though is key in reducing plastic pollution, it raise concerns about safety quality. This study provides a systematic evidence map of food contact (FCCs) that aiming identify challenges closing packaging loop. The migration potential 193 FCCs has been investigated across lifecycle, which 150 have detected into simulants/food samples. reveals much research focused on antimony (Sb), acetaldehyde some well-known endocrine-disrupting (EDCs). It indicates discusses influential factors migration, such as physical characteristics geographical origin bottles, storage conditions, reprocessing efficiency . Although, quality implications arising remain underexplored, higher Sb Bishphenol A reported recycled (rPET) compared virgin PET. attributed multiple contamination sources variability collection, sorting, decontamination efficiency. Better collaboration among stakeholders entire lifecycle needed ensure sustainable resource management rPET.

Language: Английский

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Human health risk assessment of bisphenol A (BPA) through meat products

Environmental Research, Journal Year: 2022, Volume and Issue: 213, P. 113734 - 113734

Published: June 22, 2022

Meat and meat products are often consumed in our daily diet, providing essential nutrients. Contamination by chemical hazards, including bisphenol A (BPA) products, is a concern continuously monitored. BPA well-known for its endocrine-disrupting properties, which may cause potential toxicological effects on reproductive, nervous, immune systems. Dietary consumption the main route of exposure, major contributor. exposure from focus this review. This review found that has been widely detected canned non-canned products. assumed to be predominantly migration can coatings. Relatively low levels observed source contamination these yet definitively identified. recent European Food Safety Authority (EFSA) draft opinion proposed lower tolerable intake 4 μg kg body weight (bw)-1 day-1 0.04 ng day-1, therefore health risks need addressed. investigated at farm, industrial processes, retail levels. Data gaps literature also identified improve future food safety industry. Also, unified risk assessment strategy proposed. Further understanding needed as part reduce risk, more data dose-response relationship will help comprehend adverse humans. research inform public, producers processing industry, policymakers reduction measures, thus, ensuring safety.

Language: Английский

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Effects of bisphenol A on cardiovascular disease: An epidemiological study using National Health and Nutrition Examination Survey 2003–2016 and meta-analysis

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 763, P. 142941 - 142941

Published: Oct. 14, 2020

Language: Английский

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