Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests DOI Creative Commons
Marta Llorca, Marinella Farré

Frontiers in Toxicology, Journal Year: 2021, Volume and Issue: 3

Published: Sept. 29, 2021

Humans are exposed to micro and nanoplastics (MNPLs) through inhalation, ingestion and, a lesser extent, dermal contact. In recent years, new insights indicate the potential of MNPLs cause damages human health. Particle toxicity can include oxidative stress, inflammatory lesions, then increased internalization or translocation tissues. On other hand, plastic additives used in particles, once internalized, release toxic substances. It is noteworthy that effects encompass wide range polymers chemical additives, showing various physicochemical toxicological properties, size, shape surface properties variables influencing their effects. spite research carried out recently, its early stages, further investigation required. this review article, knowledge exposure routes results on health presented discussed. Finally, current limitations main gaps body summarised.

Language: Английский

Mitochondrial Reactive Oxygen Species (ROS) Production Alters Sperm Quality DOI Creative Commons
Rosanna Chianese, Riccardo Pierantoni

Antioxidants, Journal Year: 2021, Volume and Issue: 10(1), P. 92 - 92

Published: Jan. 11, 2021

Besides ATP production, mitochondria are key organelles in several cellular functions, such as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the generation of reactive oxygen species (ROS). Despite loss majority cytoplasm occurring during spermiogenesis, mammalian sperm preserves a number that rearrange tubular structure at level flagellum midpiece. Although destroyed inside zygote, integrity functionality these seem to be critical for fertilization embryo development. The aim this review was discuss impact mitochondria-produced ROS multiple levels sperm: genome, proteome, lipidome, epigenome. How diet, aging environmental pollution may affect quality offspring health—by exacerbating oxidative stress—will also described.

Language: Английский

Citations

138
Aneuploidy in mammalian oocytes and the impact of maternal ageing DOI
Chloe Charalambous, Alexandre Webster, Melina Schuh

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 24(1), P. 27 - 44

Published: Sept. 6, 2022

Language: Английский

Citations

102
Bisphenol A and its structural analogues exhibit differential potential to induce mitochondrial dysfunction and apoptosis in human granulosa cells DOI
Guofeng Xu, Mingquan Huang, Jun Hu

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 188, P. 114713 - 114713

Published: May 1, 2024

Language: Английский

Citations

28
Toxicogenomic signatures of estrogen-related modes of action in the zebrafish embryo DOI Creative Commons

Milena Frelih,

Steve Ayobahan,

Fatma Marghany

et al.

Environmental Toxicology and Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Endocrine disruptors represent a diverse array of chemicals known to interfere with the endocrine systems both human and environmental organisms, adversely affecting reproduction, development, behavior, thus raising significant health ecological concerns. Traditional regulatory tests for activity typically involve juvenile or adult fish, which is time-consuming resource-intensive necessitates substantial animal use. This study adopts transcriptomic approach identify toxicogenomic signatures associated disruption estrogen signaling in zebrafish (Danio rerio) embryos. Utilizing modified embryo toxicity test based on Organisation Economic Co-operation Development guideline 236, embryos were exposed two sublethal concentrations estradiol, bisphenol A, fulvestrant. Despite no effects survival hatching rate observed treated groups compared controls, our effectively pinpointed several genes, including vtg1, cyp19a1b, fam20cl, sult1st2, pck1, agxtb, hsd17b12a, ptgs2a, ccn1, as linked signaling. These genes emerge promising biomarker candidates identifying distinguishing estrogen-related modes action. Additionally, this not only supports detection potential but also opens up possibilities prioritizing substances higher tier testing, could substantially reduce testing future.

Language: Английский

Citations

3
Evaluation of Oxidative stress, antioxidant enzymes and genotoxic potential of bisphenol A in fresh water bighead carp (Aristichthys nobils) fish at low concentrations DOI
Rabia Akram, Rehana Iqbal, Riaz Hussain

et al.

Environmental Pollution, Journal Year: 2020, Volume and Issue: 268, P. 115896 - 115896

Published: Nov. 6, 2020

Language: Английский

Citations

90
Bisphenol A removal and degradation pathways in microorganisms with probiotic properties DOI
Gloria Kyrila,

Antonis Katsoulas,

Vasiliki Schoretsaniti

et al.

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 413, P. 125363 - 125363

Published: Feb. 9, 2021

Language: Английский

Citations

90
Bisphenol A induces apoptosis through GPER-dependent activation of the ROS/Ca2+-ASK1-JNK pathway in human granulosa cell line KGN DOI Creative Commons
Mingquan Huang, Meizhou Huang, Xingjie Li

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 208, P. 111429 - 111429

Published: Oct. 9, 2020

Bisphenol A (BPA) is widely distributed in the environment and human surroundings closely related to occurrence of many chronic diseases including female infertility. Although BPA-induced granulosa cell apoptosis has been reported, underlying mechanisms remain unknown. In this study, we evaluated induction effect BPA exposure on regulation KGN cells (a granulosa-like tumor line). Our results indicated that induced a dose- time-dependent manner. significantly promoted expression pro-apoptotic proteins decreased mitochondrial membrane potential. We also observed high concentrations generation reactive oxygen species (ROS) calcium ion (Ca2+) accumulation. The involvement ROS Ca2+ was confirmed by pretreatment with NAC (an antioxidant) BAPTA-AM chelator). After inhibitors block corresponding signaling pathways, it found phosphorylation JNK ASK1 were inhibited. pretreated G15 GPER inhibitor) accumulation These suggest induces through GPER-dependent activation ROS/Ca2+-ASK1-JNK pathway. study provides which ovarian dysfunction.

Language: Английский

Citations

79
Applications and influencing factors of the biochar-persulfate based advanced oxidation processes for the remediation of groundwater and soil contaminated with organic compounds DOI
Tianhao Liu, Bin Yao,

Zirui Luo

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 836, P. 155421 - 155421

Published: April 25, 2022

Language: Английский

Citations

63
Effects of BPA, BPS, and BPF on Oxidative Stress and Antioxidant Enzyme Expression in Bovine Oocytes and Spermatozoa DOI Open Access

Mimi V. Nguyen,

Reem Sabry,

Ola S. Davis

et al.

Genes, Journal Year: 2022, Volume and Issue: 13(1), P. 142 - 142

Published: Jan. 14, 2022

Bisphenol A (BPA) and its analogs, bisphenol S (BPS) F (BPF), might impact fertility by altering oxidative stress pathways. Here, we hypothesize that bisphenols-induced is responsible for decreased gamete quality. In both female (cumulus-oocyte-complexes—COCs) male (spermatozoa), was measured CM-H2DCFDA assay key ROS scavengers (SOD1, SOD2, GPX1, GPX4, CAT) were quantified at the mRNA protein levels using qPCR Western blot (COCs)/immunofluorescence (sperm). Either treated in five groups: control, vehicle, 0.05 mg/mL of BPA, BPS, or BPF. Our results show elevated BPA-treated COCs but production BPS- BPF-treated spermatozoa. Additionally, expression GPX4 (p < 0.05). sperm, motility 0.03), not morphology, significantly altered bisphenols. SOD1 increased, while reduced. These support BPA’s ability to alter oocytes and, a lesser extent, sperm. However, BPS BPF likely act through different mechanisms.

Language: Английский

Citations

49
Mediterranean Diet as a Shield against Male Infertility and Cancer Risk Induced by Environmental Pollutants: A Focus on Flavonoids DOI Open Access
Luigi Montano, Alessandro Maugeri, Maria Grazia Volpe

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1568 - 1568

Published: Jan. 29, 2022

The role of environmental factors in influencing health status is well documented. Heavy metals, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls, dioxins, pesticides, ultrafine particles, produced by human activities put a strain on the body’s entire defense system. Therefore, together with public measures, evidence-based individual resilience measures are necessary to mitigate cancer risk under stress and prevent reproductive dysfunction non-communicable diseases; this especially relevant for workers occupationally exposed pollutants and/or populations residing highly polluted areas. Mediterranean diet characterized high intake fruits vegetables rich flavonoids, that can promote elimination tissues fluids their effects through different mechanisms. In review, we collected evidence from pre-clinical clinical studies showing impairment male fertility gonadal development, as cancers system, due exposure organic inorganic pollutants, may be counteracted flavonoids.

Language: Английский

Citations

47