Type 2 diabetes

The Lancet, Journal Year: 2022, Volume and Issue: 400(10365), P. 1803 - 1820

Published: Nov. 1, 2022

Language: Английский

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Diabetes Fact Sheet in Korea 2021

Diabetes & Metabolism Journal, Journal Year: 2022, Volume and Issue: 46(3), P. 417 - 426

Published: May 26, 2022

This study aimed to investigate the prevalence and management of diabetes mellitus, risk-factor control, comorbidities among Korean adults.

Language: Английский

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Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning

Cell Metabolism, Journal Year: 2021, Volume and Issue: 33(3), P. 479 - 498

Published: Jan. 22, 2021

Language: Английский

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Nitric oxide signalling in kidney regulation and cardiometabolic health

Nature Reviews Nephrology, Journal Year: 2021, Volume and Issue: 17(9), P. 575 - 590

Published: June 1, 2021

Language: Английский

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ECMM/ISHAM recommendations for clinical management of COVID‐19 associated mucormycosis in low‐ and middle‐income countries

Mycoses, Journal Year: 2021, Volume and Issue: 64(9), P. 1028 - 1037

Published: June 16, 2021

Reports are increasing on the emergence of COVID-19-associated mucormycosis (CAM) globally, driven particularly by low- and middle-income countries. The recent unprecedented surge CAM in India has drawn worldwide attention. More than 28,252 cases counted is first country where been declared a notifiable disease. However, misconception management, diagnosing treating this infection continue to occur. Thus, European Confederation Medical Mycology (ECMM) International Society for Human Animal (ISHAM) felt need address clinical management This article provides comprehensive document help clinicians managing infection. Uncontrolled diabetes mellitus inappropriate (high dose or not indicated) corticosteroid use major predisposing factors surge. High counts Mucorales spores both indoor outdoor environments, immunosuppressive impact COVID-19 patients as well immunotherapy possible additional factors. Furthermore, hyperglycaemic state leads an increased expression glucose regulated protein (GRP- 78) endothelial cells that may entry into tissues. Rhino-orbital most common presentation followed pulmonary mucormycosis. Recommendations focused early suspicion disease confirmation diagnosis. Regarding glycaemic control, elimination therapy, extensive surgical debridement antifungal therapy standards proper care. Due limited availability amphotericin B formulations during present epidemic, alternative therapies also discussed.

Language: Английский

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Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2

Cell Metabolism, Journal Year: 2021, Volume and Issue: 33(11), P. 2174 - 2188.e5

Published: Sept. 16, 2021

Language: Английский

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Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 18(9), P. 540 - 557

Published: May 18, 2022

Language: Английский

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Interactions of SARS-CoV-2 with the Blood–Brain Barrier

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(5), P. 2681 - 2681

Published: March 6, 2021

Emerging data indicate that neurological complications occur as a consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The blood–brain barrier (BBB) is critical interface regulates entry circulating molecules into the CNS, and regulated by signals arise from brain blood compartments. In this review, we discuss mechanisms which SARS-CoV-2 interactions with BBB may contribute to dysfunction associated disease 2019 (COVID-19), caused SARS-CoV-2. We consider aspects peripheral disease, such hypoxia systemic inflammatory response syndrome/cytokine storm, well CNS infection viral brain. also contribution risk factors for developing COVID-19 could increase or otherwise damage

Language: Английский

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Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA)

Cardiovascular Research, Journal Year: 2021, Volume and Issue: 117(14), P. 2705 - 2729

Published: Sept. 11, 2021

The cardiovascular system is significantly affected in coronavirus disease-19 (COVID-19). Microvascular injury, endothelial dysfunction, and thrombosis resulting from viral infection or indirectly related to the intense systemic inflammatory immune responses are characteristic features of severe COVID-19. Pre-existing disease load linked myocardial injury worse outcomes. vascular response cytokine production interaction between acute respiratory syndrome coronavirus-2 (SARS-CoV-2) angiotensin-converting enzyme 2 receptor may lead a significant reduction cardiac contractility subsequent dysfunction. In addition, considerable proportion patients who have been infected with SARS-CoV-2 do not fully recover continue experience large number symptoms post-acute complications absence detectable infection. This conditions often referred as 'post-acute COVID-19' multiple causes. Viral reservoirs lingering fragments RNA proteins contribute condition. Systemic COVID-19 has potential increase fibrosis which turn impair remodelling. Here, we summarize current knowledge sequelae As pandemic continues new variants emerge, can advance our underlying mechanisms only by integrating understanding pathophysiology corresponding clinical findings. Identification biomarkers complications, development effective treatments for crucial importance.

Language: Английский

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Tirzepatide, a New Era of Dual-Targeted Treatment for Diabetes and Obesity: A Mini-Review

Molecules, Journal Year: 2022, Volume and Issue: 27(13), P. 4315 - 4315

Published: July 5, 2022

The prevalence of obesity and diabetes is an increasing global problem, especially in developed countries, referred to as the twin epidemics. As such, advanced treatment approaches are needed. Tirzepatide, known a 'twincretin', 'first-in-class' only dual glucagon-like peptide-1 (GLP-1) glucose-dependent insulinotropic peptide (GIP) receptor agonist, that can significantly reduce glycemic levels improve insulin sensitivity, well reducing body weight by more than 20% improving lipid metabolism. This novel anti-diabetic drug synthetic analog human GIP hormone with C

Language: Английский

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